BRD-K69840642_HDAC6 inhibitor ISOX_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

309 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACOT7 acyl-CoA thioesterase 7
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTPBP1 ATP/GTP binding protein 1
ALOX5 arachidonate 5-lipoxygenase
ANKRD46 ankyrin repeat domain 46
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ANOS1 anosmin 1
AQP3 aquaporin 3 (Gill blood group)
ARHGAP29 Rho GTPase activating protein 29
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARL3 ADP-ribosylation factor-like 3
ASMTL acetylserotonin O-methyltransferase-like
AVPI1 arginine vasopressin-induced 1
BAMBI BMP and activin membrane-bound inhibitor
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV2 caveolin 2
CCND3 cyclin D3
CD24 CD24 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFD complement factor D (adipsin)
CHMP1B charged multivesicular body protein 1B
COBL cordon-bleu WH2 repeat protein
CPD carboxypeptidase D
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYB5R1 cytochrome b5 reductase 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DHCR7 7-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP5 dual specificity phosphatase 5
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
ELOVL5 ELOVL fatty acid elongase 5
EML4 echinoderm microtubule associated protein like 4
ENAH enabled homolog (Drosophila)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EZR ezrin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS3 fatty acid desaturase 3
FAM107A family with sequence similarity 107, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FHL1 four and a half LIM domains 1
FKBP1A FK506 binding protein 1A, 12kDa
FYN FYN proto-oncogene, Src family tyrosine kinase
G0S2 G0/G1 switch 2
G6PD glucose-6-phosphate dehydrogenase
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATA2 GATA binding protein 2
GCH1 GTP cyclohydrolase 1
GLRX glutaredoxin (thioltransferase)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX3 glutathione peroxidase 3
GRK5 G protein-coupled receptor kinase 5
HECA headcase homolog (Drosophila)
HES1 hes family bHLH transcription factor 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HPCAL1 hippocalcin-like 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
KAZN kazrin, periplakin interacting protein
KCTD12 potassium channel tetramerization domain containing 12
LGALS3 lectin, galactoside-binding, soluble, 3
LGMN legumain
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MEF2A myocyte enhancer factor 2A
METTL7A methyltransferase like 7A
MFAP3L microfibrillar-associated protein 3-like
MLF1 myeloid leukemia factor 1
MNAT1 MNAT CDK-activating kinase assembly factor 1
MPC1 mitochondrial pyruvate carrier 1
MSMO1 methylsterol monooxygenase 1
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
MTUS1 microtubule associated tumor suppressor 1
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NLRP2 NLR family, pyrin domain containing 2
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
OSBPL8 oxysterol binding protein-like 8
OSR2 odd-skipped related transciption factor 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PDLIM3 PDZ and LIM domain 3
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PID1 phosphotyrosine interaction domain containing 1
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PLA2G15 phospholipase A2, group XV
PLA2G16 phospholipase A2, group XVI
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLB polymerase (DNA directed), beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSENEN presenilin enhancer gamma secretase subunit
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB31 RAB31, member RAS oncogene family
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS10 regulator of G-protein signaling 10
RGS2 regulator of G-protein signaling 2
ROGDI rogdi homolog (Drosophila)
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCPEP1 serine carboxypeptidase 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGCE sarcoglycan, epsilon
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNN stannin
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPP1 secreted phosphoprotein 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRGN serglycin
SRPK2 SRSF protein kinase 2
STOM stomatin
STX7 syntaxin 7
STXBP1 syntaxin binding protein 1
TBPL1 TBP-like 1
TBXA2R thromboxane A2 receptor
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TKTL1 transketolase-like 1
TM7SF2 transmembrane 7 superfamily member 2
TOB1 transducer of ERBB2, 1
TPD52L1 tumor protein D52-like 1
TPPP3 tubulin polymerization-promoting protein family member 3
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TUFT1 tuftelin 1
TYROBP TYRO protein tyrosine kinase binding protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WDR47 WD repeat domain 47
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZFP36 ZFP36 ring finger protein
ZNF277 zinc finger protein 277
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ARID1A AT rich interactive domain 1A (SWI-like)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
AURKA aurora kinase A
BEX1 brain expressed, X-linked 1
C7ORF49 chromosome 7 open reading frame 49
CBR3 carbonyl reductase 3
CCNB2 cyclin B2
CCND1 cyclin D1
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
COMT catechol-O-methyltransferase
CREBBP CREB binding protein
CTSO cathepsin O
DCK deoxycytidine kinase
DEK DEK proto-oncogene
DKK1 dickkopf WNT signaling pathway inhibitor 1
DRAM1 DNA-damage regulated autophagy modulator 1
ECT2 epithelial cell transforming 2
EFS embryonal Fyn-associated substrate
EGFR epidermal growth factor receptor
EIF5 eukaryotic translation initiation factor 5
EMP3 epithelial membrane protein 3
EREG epiregulin
FAM193A family with sequence similarity 193, member A
FAM57A family with sequence similarity 57, member A
FBXO5 F-box protein 5
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GABPB1 GA binding protein transcription factor, beta subunit 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GSAP gamma-secretase activating protein
GSPT2 G1 to S phase transition 2
GSTO1 glutathione S-transferase omega 1
GTSE1 G-2 and S-phase expressed 1
HAS2 hyaluronan synthase 2
HDGF hepatoma-derived growth factor
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXB2 homeobox B2
HOXB6 homeobox B6
HOXB7 homeobox B7
HOXC6 homeobox C6
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGFBP6 insulin-like growth factor binding protein 6
IRAK1 interleukin-1 receptor-associated kinase 1
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0101 KIAA0101
KIAA0368 KIAA0368
KIF18B kinesin family member 18B
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KPNB1 karyopherin (importin) beta 1
KRT14 keratin 14, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LMNB2 lamin B2
LOX lysyl oxidase
LRRC41 leucine rich repeat containing 41
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MECOM MDS1 and EVI1 complex locus
MEPCE methylphosphate capping enzyme
MET MET proto-oncogene, receptor tyrosine kinase
MICALL1 MICAL-like 1
MKI67 marker of proliferation Ki-67
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOK MOK protein kinase
MRPS2 mitochondrial ribosomal protein S2
MSL1 male-specific lethal 1 homolog (Drosophila)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMT1 N-myristoyltransferase 1
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PARVB parvin, beta
PAX8 paired box 8
PBK PDZ binding kinase
PHIP pleckstrin homology domain interacting protein
PI3 peptidase inhibitor 3, skin-derived
PLK1 polo-like kinase 1
PMF1 polyamine-modulated factor 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PTBP1 polypyrimidine tract binding protein 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
RAB13 RAB13, member RAS oncogene family
RBMX RNA binding motif protein, X-linked
RCN1 reticulocalbin 1, EF-hand calcium binding domain
S100A2 S100 calcium binding protein A2
SENP6 SUMO1/sentrin specific peptidase 6
SETBP1 SET binding protein 1
SHCBP1 SHC SH2-domain binding protein 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SON SON DNA binding protein
SORBS3 sorbin and SH3 domain containing 3
SPAG7 sperm associated antigen 7
SPC25 SPC25, NDC80 kinetochore complex component
SRSF5 serine/arginine-rich splicing factor 5
STAG2 stromal antigen 2
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUMO3 small ubiquitin-like modifier 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBGCP3 tubulin, gamma complex associated protein 3
TYMS thymidylate synthetase
TYRP1 tyrosinase-related protein 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2Z ubiquitin-conjugating enzyme E2Z
UBE3A ubiquitin protein ligase E3A
USP22 ubiquitin specific peptidase 22
WDR13 WD repeat domain 13
WEE1 WEE1 G2 checkpoint kinase
WHSC1 Wolf-Hirschhorn syndrome candidate 1
XBP1 X-box binding protein 1
ZBED1 zinc finger, BED-type containing 1
ZWINT ZW10 interacting kinetochore protein
Funding