BRD-K69840642_HDAC6 inhibitor ISOX_HCC15_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

166 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_HCC15_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA1 actin, alpha 1, skeletal muscle
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADCK3 aarF domain containing kinase 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKAP12 A kinase (PRKA) anchor protein 12
ANGPTL4 angiopoietin-like 4
ARHGAP29 Rho GTPase activating protein 29
ATHL1 ATH1, acid trehalase-like 1 (yeast)
C1QTNF3 C1q and tumor necrosis factor related protein 3
CA1 carbonic anhydrase I
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNG2 cyclin G2
CD200 CD200 molecule
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEMIP cell migration inducing protein, hyaluronan binding
CHMP6 charged multivesicular body protein 6
CLU clusterin
CNN3 calponin 3, acidic
CORO1A coronin, actin binding protein, 1A
CPB1 carboxypeptidase B1 (tissue)
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL5 chemokine (C-X-C motif) ligand 5
CYB5A cytochrome b5 type A (microsomal)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPAS1 endothelial PAS domain protein 1
FADS3 fatty acid desaturase 3
FAM117A family with sequence similarity 117, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FHL1 four and a half LIM domains 1
FKBP14 FK506 binding protein 14, 22 kDa
FN1 fibronectin 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPX3 glutathione peroxidase 3
GRB7 growth factor receptor-bound protein 7
HBD hemoglobin, delta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPCAL1 hippocalcin-like 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
ITM2A integral membrane protein 2A
KCTD5 potassium channel tetramerization domain containing 5
LPIN1 lipin 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAOB monoamine oxidase B
MB myoglobin
MEF2C myocyte enhancer factor 2C
MLF1 myeloid leukemia factor 1
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
NOSIP nitric oxide synthase interacting protein
OPTN optineurin
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG10 paternally expressed 10
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G15 phospholipase A2, group XV
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PXDN peroxidasin
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAP1GAP RAP1 GTPase activating protein
REG1A regenerating islet-derived 1 alpha
REG1B regenerating islet-derived 1 beta
RTN2 reticulon 2
SDC2 syndecan 2
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SKAP2 src kinase associated phosphoprotein 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC38A1 solute carrier family 38, member 1
SMAD7 SMAD family member 7
SPINK1 serine peptidase inhibitor, Kazal type 1
STK17A serine/threonine kinase 17a
TIMP3 TIMP metallopeptidase inhibitor 3
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
WIPI1 WD repeat domain, phosphoinositide interacting 1
XYLT1 xylosyltransferase I

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANO1 anoctamin 1, calcium activated chloride channel
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
AUTS2 autism susceptibility candidate 2
C2CD5 C2 calcium-dependent domain containing 5
CBR3 carbonyl reductase 3
CCNB1 cyclin B1
CD44 CD44 molecule (Indian blood group)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
COL5A2 collagen, type V, alpha 2
DEK DEK proto-oncogene
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPP4 dipeptidyl-peptidase 4
DUSP4 dual specificity phosphatase 4
EPCAM epithelial cell adhesion molecule
FAM57A family with sequence similarity 57, member A
FBXO11 F-box protein 11
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
HOXA10 homeobox A10
IGF1R insulin-like growth factor 1 receptor
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KIAA0485 uncharacterized LOC57235
KIAA0907 KIAA0907
KIAA1551 KIAA1551
KLK11 kallikrein-related peptidase 11
KYNU kynureninase
LHX2 LIM homeobox 2
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
MSLN mesothelin
MYO5C myosin VC
MYOF myoferlin
N4BP2L2 NEDD4 binding protein 2-like 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP85 nucleoporin 85kDa
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PIR pirin (iron-binding nuclear protein)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RRM1 ribonucleotide reductase M1
SENP6 SUMO1/sentrin specific peptidase 6
SLPI secretory leukocyte peptidase inhibitor
SNRPE small nuclear ribonucleoprotein polypeptide E
SPRY2 sprouty homolog 2 (Drosophila)
SRSF1 serine/arginine-rich splicing factor 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMPO thymopoietin
TSC22D1 TSC22 domain family, member 1
TSKU tsukushi, small leucine rich proteoglycan
UBE2C ubiquitin-conjugating enzyme E2C
WEE1 WEE1 G2 checkpoint kinase
ZSCAN31 zinc finger and SCAN domain containing 31
Funding