BRD-K69840642_HDAC6 inhibitor ISOX_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

221 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD17A abhydrolase domain containing 17A
ACOT7 acyl-CoA thioesterase 7
ADAM10 ADAM metallopeptidase domain 10
ADD3 adducin 3 (gamma)
AHCYL1 adenosylhomocysteinase-like 1
ALAS1 5'-aminolevulinate synthase 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDOC aldolase C, fructose-bisphosphate
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APLP2 amyloid beta (A4) precursor-like protein 2
ATG2A autophagy related 2A
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSG basigin (Ok blood group)
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCND3 cyclin D3
CCNG2 cyclin G2
CD9 CD9 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEP70 centrosomal protein 70kDa
CHEK2 checkpoint kinase 2
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN3 claudin 3
CORO1A coronin, actin binding protein, 1A
COTL1 coactosin-like F-actin binding protein 1
CPM carboxypeptidase M
DHRS2 dehydrogenase/reductase (SDR family) member 2
EFNB2 ephrin-B2
EZR ezrin
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FHL1 four and a half LIM domains 1
FOXO4 forkhead box O4
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNS glucosamine (N-acetyl)-6-sulfatase
GRN granulin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMG20B high mobility group 20B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
ICAM1 intercellular adhesion molecule 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFT57 intraflagellar transport 57
ITFG1 integrin alpha FG-GAP repeat containing 1
KIAA0930 KIAA0930
LAPTM5 lysosomal protein transmembrane 5
LDHB lactate dehydrogenase B
LGALS1 lectin, galactoside-binding, soluble, 1
LTA4H leukotriene A4 hydrolase
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
NBL1 neuroblastoma 1, DAN family BMP antagonist
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NOSIP nitric oxide synthase interacting protein
OAT ornithine aminotransferase
OPTN optineurin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PLA2G15 phospholipase A2, group XV
PLAT plasminogen activator, tissue
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PNMA2 paraneoplastic Ma antigen 2
PNP purine nucleoside phosphorylase
PRKCD protein kinase C, delta
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPRD protein tyrosine phosphatase, receptor type, D
QPCT glutaminyl-peptide cyclotransferase
RABAC1 Rab acceptor 1 (prenylated)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RSRP1 arginine/serine-rich protein 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SNN stannin
SPAG9 sperm associated antigen 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STXBP1 syntaxin binding protein 1
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TKTL1 transketolase-like 1
TLE4 transducin-like enhancer of split 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUBB3 tubulin, beta 3 class III
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
VIM vimentin
WDTC1 WD and tetratricopeptide repeats 1
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AKAP8 A kinase (PRKA) anchor protein 8
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA1 annexin A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
BCLAF1 BCL2-associated transcription factor 1
BEX1 brain expressed, X-linked 1
CBFB core-binding factor, beta subunit
CCNA2 cyclin A2
CCND1 cyclin D1
CST7 cystatin F (leukocystatin)
DCK deoxycytidine kinase
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF5A eukaryotic translation initiation factor 5A
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EREG epiregulin
F5 coagulation factor V (proaccelerin, labile factor)
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FOSL1 FOS-like antigen 1
GAS2 growth arrest-specific 2
GBP1 guanylate binding protein 1, interferon-inducible
GPR171 G protein-coupled receptor 171
GPX2 glutathione peroxidase 2
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HMGN3 high mobility group nucleosomal binding domain 3
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HP haptoglobin
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
KEAP1 kelch-like ECH-associated protein 1
KPNB1 karyopherin (importin) beta 1
KRT13 keratin 13, type I
KYNU kynureninase
LAPTM4B lysosomal protein transmembrane 4 beta
LMNB1 lamin B1
LYZ lysozyme
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM3 minichromosome maintenance complex component 3
MCTP1 multiple C2 domains, transmembrane 1
MRPL12 mitochondrial ribosomal protein L12
MRPL57 mitochondrial ribosomal protein L57
MTA1 metastasis associated 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
ORM1 orosomucoid 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTMA prothymosin, alpha
RBP4 retinol binding protein 4, plasma
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RELN reelin
RIPK2 receptor-interacting serine-threonine kinase 2
RREB1 ras responsive element binding protein 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SENP6 SUMO1/sentrin specific peptidase 6
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
SNRPE small nuclear ribonucleoprotein polypeptide E
SORBS2 sorbin and SH3 domain containing 2
SORBS3 sorbin and SH3 domain containing 3
SOX9 SRY (sex determining region Y)-box 9
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STEAP1 six transmembrane epithelial antigen of the prostate 1
STEAP3 STEAP family member 3, metalloreductase
STK26 serine/threonine protein kinase 26
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TF transferrin
TFR2 transferrin receptor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TSKU tsukushi, small leucine rich proteoglycan
TYMS thymidylate synthetase
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UFC1 ubiquitin-fold modifier conjugating enzyme 1
USP22 ubiquitin specific peptidase 22
WSB2 WD repeat and SOCS box containing 2
XBP1 X-box binding protein 1
Funding