BRD-K69840642_HDAC6 inhibitor ISOX_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

336 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABHD3 abhydrolase domain containing 3
ACOT7 acyl-CoA thioesterase 7
ADA adenosine deaminase
ADCY9 adenylate cyclase 9
ADD3 adducin 3 (gamma)
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
ANOS1 anosmin 1
ANXA6 annexin A6
AOX1 aldehyde oxidase 1
ARHGAP29 Rho GTPase activating protein 29
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASMTL acetylserotonin O-methyltransferase-like
ASRGL1 asparaginase like 1
ATG2A autophagy related 2A
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BLVRA biliverdin reductase A
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPGM 2,3-bisphosphoglycerate mutase
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCND3 cyclin D3
CD3D CD3d molecule, delta (CD3-TCR complex)
CDK2 cyclin-dependent kinase 2
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
CETN2 centrin, EF-hand protein, 2
CGRRF1 cell growth regulator with ring finger domain 1
CHPT1 choline phosphotransferase 1
CLDN3 claudin 3
CLIC4 chloride intracellular channel 4
CLIC5 chloride intracellular channel 5
COL10A1 collagen, type X, alpha 1
CORO1A coronin, actin binding protein, 1A
CPM carboxypeptidase M
CPVL carboxypeptidase, vitellogenic-like
CRAT carnitine O-acetyltransferase
CRIP1 cysteine-rich protein 1 (intestinal)
CTSV cathepsin V
CYB5R1 cytochrome b5 reductase 1
CYBB cytochrome b-245, beta polypeptide
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYLD cylindromatosis (turban tumor syndrome)
DDIT4 DNA-damage-inducible transcript 4
DGKA diacylglycerol kinase, alpha 80kDa
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
DSTN destrin (actin depolymerizing factor)
ECHDC3 enoyl CoA hydratase domain containing 3
EIF5A eukaryotic translation initiation factor 5A
FADS3 fatty acid desaturase 3
FAM117A family with sequence similarity 117, member A
FBLN5 fibulin 5
FBXO3 F-box protein 3
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FKBP1A FK506 binding protein 1A, 12kDa
FKBP1B FK506 binding protein 1B, 12.6 kDa
FN1 fibronectin 1
FOXO4 forkhead box O4
GADD45B growth arrest and DNA-damage-inducible, beta
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GOLGA7 golgin A7
GSTM3 glutathione S-transferase mu 3 (brain)
H1F0 H1 histone family, member 0
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HSPA2 heat shock 70kDa protein 2
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT57 intraflagellar transport 57
IGFBP5 insulin-like growth factor binding protein 5
IGKV1-5 immunoglobulin kappa variable 1-5
IL32 interleukin 32
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
IQGAP2 IQ motif containing GTPase activating protein 2
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KCTD5 potassium channel tetramerization domain containing 5
KLHL24 kelch-like family member 24
L1CAM L1 cell adhesion molecule
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LGALS1 lectin, galactoside-binding, soluble, 1
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2
LTA4H leukotriene A4 hydrolase
MAGEB2 melanoma antigen family B2
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPRE2 microtubule-associated protein, RP/EB family, member 2
METRN meteorin, glial cell differentiation regulator
MICB MHC class I polypeptide-related sequence B
MLF1 myeloid leukemia factor 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MXI1 MAX interactor 1, dimerization protein
MXRA7 matrix-remodelling associated 7
NCOA3 nuclear receptor coactivator 3
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NEU1 sialidase 1 (lysosomal sialidase)
NMT2 N-myristoyltransferase 2
NOSIP nitric oxide synthase interacting protein
OAT ornithine aminotransferase
OPN3 opsin 3
OPTN optineurin
OSTM1 osteopetrosis associated transmembrane protein 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PEG10 paternally expressed 10
PHF20 PHD finger protein 20
PHKG2 phosphorylase kinase, gamma 2 (testis)
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLA2G15 phospholipase A2, group XV
PNMA2 paraneoplastic Ma antigen 2
PNMAL1 paraneoplastic Ma antigen family-like 1
PRDX1 peroxiredoxin 1
PRKCD protein kinase C, delta
PSENEN presenilin enhancer gamma secretase subunit
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RABAC1 Rab acceptor 1 (prenylated)
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RIMS3 regulating synaptic membrane exocytosis 3
RIOK3 RIO kinase 3
ROGDI rogdi homolog (Drosophila)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RTN3 reticulon 3
SCPEP1 serine carboxypeptidase 1
SEPT6 septin 6
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGCE sarcoglycan, epsilon
SGK1 serum/glucocorticoid regulated kinase 1
SKAP2 src kinase associated phosphoprotein 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNAP23 synaptosomal-associated protein, 23kDa
SNN stannin
SPAG9 sperm associated antigen 9
STAT1 signal transducer and activator of transcription 1, 91kDa
STK17A serine/threonine kinase 17a
STOM stomatin
STXBP1 syntaxin binding protein 1
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBPL1 TBP-like 1
TIMP3 TIMP metallopeptidase inhibitor 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TRAK2 trafficking protein, kinesin binding 2
TRIM36 tripartite motif containing 36
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAT1 vesicle amine transport 1
VIM vimentin
WDR47 WD repeat domain 47
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ADORA2B adenosine A2b receptor
AGR2 anterior gradient 2
AKAP8 A kinase (PRKA) anchor protein 8
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMOTL2 angiomotin like 2
ANXA10 annexin A10
AQP9 aquaporin 9
ARID1A AT rich interactive domain 1A (SWI-like)
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BCLAF1 BCL2-associated transcription factor 1
BEX1 brain expressed, X-linked 1
BMP4 bone morphogenetic protein 4
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CCNA2 cyclin A2
CD58 CD58 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHD1L chromodomain helicase DNA binding protein 1-like
COMT catechol-O-methyltransferase
CTBP1 C-terminal binding protein 1
CTPS1 CTP synthase 1
CTSO cathepsin O
CXCL8 chemokine (C-X-C motif) ligand 8
CYTIP cytohesin 1 interacting protein
DACH1 dachshund family transcription factor 1
DCTD dCMP deaminase
DENND2D DENN/MADD domain containing 2D
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
EGFR epidermal growth factor receptor
EIF4B eukaryotic translation initiation factor 4B
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ERAP2 endoplasmic reticulum aminopeptidase 2
EREG epiregulin
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FANCL Fanconi anemia, complementation group L
FERMT1 fermitin family member 1
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATAD1 GATA zinc finger domain containing 1
GEMIN4 gem (nuclear organelle) associated protein 4
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GSAP gamma-secretase activating protein
GSE1 Gse1 coiled-coil protein
GSTO1 glutathione S-transferase omega 1
GTPBP8 GTP-binding protein 8 (putative)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL1R2 interleukin 1 receptor, type II
IRAK1 interleukin-1 receptor-associated kinase 1
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KCNK1 potassium channel, two pore domain subfamily K, member 1
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KPNB1 karyopherin (importin) beta 1
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LMNB2 lamin B2
LPL lipoprotein lipase
LTF lactotransferrin
MCTP1 multiple C2 domains, transmembrane 1
MECOM MDS1 and EVI1 complex locus
MEPCE methylphosphate capping enzyme
MET MET proto-oncogene, receptor tyrosine kinase
MRPS30 mitochondrial ribosomal protein S30
MTA1 metastasis associated 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NOP16 NOP16 nucleolar protein
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OBSL1 obscurin-like 1
PGLS 6-phosphogluconolactonase
PHIP pleckstrin homology domain interacting protein
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIGG phosphatidylinositol glycan anchor biosynthesis, class G
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
PMF1 polyamine-modulated factor 1
PNN pinin, desmosome associated protein
POGK pogo transposable element with KRAB domain
PON2 paraoxonase 2
PRDX4 peroxiredoxin 4
PRR7 proline rich 7 (synaptic)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
REPIN1 replication initiator 1
RPL10 ribosomal protein L10
RPP38 ribonuclease P/MRP 38kDa subunit
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SENP6 SUMO1/sentrin specific peptidase 6
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC35F2 solute carrier family 35, member F2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SMAGP small cell adhesion glycoprotein
SMYD2 SET and MYND domain containing 2
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRY2 sprouty homolog 2 (Drosophila)
ST7 suppression of tumorigenicity 7
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
STEAP3 STEAP family member 3, metalloreductase
STK26 serine/threonine protein kinase 26
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCERG1 transcription elongation regulator 1
TDO2 tryptophan 2,3-dioxygenase
TFF1 trefoil factor 1
TGIF1 TGFB-induced factor homeobox 1
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TLK1 tousled-like kinase 1
TPBG trophoblast glycoprotein
TSKU tsukushi, small leucine rich proteoglycan
TSPAN8 tetraspanin 8
TTC39A tetratricopeptide repeat domain 39A
UCK2 uridine-cytidine kinase 2
UFC1 ubiquitin-fold modifier conjugating enzyme 1
UMPS uridine monophosphate synthetase
UPK1B uroplakin 1B
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
XBP1 X-box binding protein 1
ZBTB38 zinc finger and BTB domain containing 38
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