BRD-K69840642_HDAC6 inhibitor ISOX_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

268 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
ANKRD46 ankyrin repeat domain 46
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
ARHGAP29 Rho GTPase activating protein 29
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CALCOCO2 calcium binding and coiled-coil domain 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCDC92 coiled-coil domain containing 92
CCL20 chemokine (C-C motif) ligand 20
CCND3 cyclin D3
CCNG2 cyclin G2
CD47 CD47 molecule
CD9 CD9 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEMIP cell migration inducing protein, hyaluronan binding
CGRRF1 cell growth regulator with ring finger domain 1
CLDND1 claudin domain containing 1
CLIC5 chloride intracellular channel 5
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CORO1A coronin, actin binding protein, 1A
CP ceruloplasmin (ferroxidase)
CRLF1 cytokine receptor-like factor 1
CTSA cathepsin A
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYLD cylindromatosis (turban tumor syndrome)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV5 ets variant 5
EYA1 EYA transcriptional coactivator and phosphatase 1
FAM117A family with sequence similarity 117, member A
FAM171A1 family with sequence similarity 171, member A1
FN1 fibronectin 1
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GOLGA7 golgin A7
GRK5 G protein-coupled receptor kinase 5
GRN granulin
HECA headcase homolog (Drosophila)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCTD5 potassium channel tetramerization domain containing 5
KIF5C kinesin family member 5C
LDHB lactate dehydrogenase B
LGALS4 lectin, galactoside-binding, soluble, 4
LIPA lipase A, lysosomal acid, cholesterol esterase
LMO3 LIM domain only 3 (rhombotin-like 2)
LPIN1 lipin 1
LPIN2 lipin 2
MAGEB2 melanoma antigen family B2
MAGED1 melanoma antigen family D1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBNL2 muscleblind-like splicing regulator 2
MCOLN1 mucolipin 1
MGST3 microsomal glutathione S-transferase 3
MLF1 myeloid leukemia factor 1
MMD monocyte to macrophage differentiation-associated
MOSPD1 motile sperm domain containing 1
MSMO1 methylsterol monooxygenase 1
MVP major vault protein
MXRA7 matrix-remodelling associated 7
NCAM1 neural cell adhesion molecule 1
NET1 neuroepithelial cell transforming 1
NEU1 sialidase 1 (lysosomal sialidase)
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLA2G15 phospholipase A2, group XV
PNMA2 paraneoplastic Ma antigen 2
PRKCA protein kinase C, alpha
PRSS3 protease, serine, 3
PRUNE2 prune homolog 2 (Drosophila)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAB29 RAB29, member RAS oncogene family
RAB40B RAB40B, member RAS oncogene family
RAB5B RAB5B, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RBP1 retinol binding protein 1, cellular
REEP1 receptor accessory protein 1
RGS2 regulator of G-protein signaling 2
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAGD Ras-related GTP binding D
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCML1 sex comb on midleg-like 1 (Drosophila)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMTN smoothelin
SPAG9 sperm associated antigen 9
SRGN serglycin
SST somatostatin
STXBP1 syntaxin binding protein 1
TBPL1 TBP-like 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TLE4 transducin-like enhancer of split 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM41B transmembrane protein 41B
TNS1 tensin 1
TRIM2 tripartite motif containing 2
TSPAN7 tetraspanin 7
TUBA4A tubulin, alpha 4a
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCAM1 vascular cell adhesion molecule 1
VIM vimentin
WASF1 WAS protein family, member 1
WDTC1 WD and tetratricopeptide repeats 1
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
AGR2 anterior gradient 2
AK4 adenylate kinase 4
AKAP8 A kinase (PRKA) anchor protein 8
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
AP1M2 adaptor-related protein complex 1, mu 2 subunit
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG1 BCL2-associated athanogene
BCL6 B-cell CLL/lymphoma 6
CCNA2 cyclin A2
CCND1 cyclin D1
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CKAP4 cytoskeleton-associated protein 4
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CYB561 cytochrome b561
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLG5 discs, large homolog 5 (Drosophila)
DST dystonin
EIF4B eukaryotic translation initiation factor 4B
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF5A eukaryotic translation initiation factor 5A
EPCAM epithelial cell adhesion molecule
ESR1 estrogen receptor 1
ESRP1 epithelial splicing regulatory protein 1
FAM57A family with sequence similarity 57, member A
FBXO11 F-box protein 11
FHL2 four and a half LIM domains 2
FXYD3 FXYD domain containing ion transport regulator 3
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA3 GATA binding protein 3
GOLGA4 golgin A4
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GREB1 growth regulation by estrogen in breast cancer 1
HOXB7 homeobox B7
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGF1R insulin-like growth factor 1 receptor
ING3 inhibitor of growth family, member 3
IRAK1 interleukin-1 receptor-associated kinase 1
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KLF4 Kruppel-like factor 4 (gut)
KPNB1 karyopherin (importin) beta 1
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
KYNU kynureninase
LMNB1 lamin B1
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKS myristoylated alanine-rich protein kinase C substrate
MECOM MDS1 and EVI1 complex locus
MLPH melanophilin
MRPS30 mitochondrial ribosomal protein S30
MSMB microseminoprotein, beta-
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOF myoferlin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NINJ1 ninjurin 1
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
NUP62 nucleoporin 62kDa
P3H2 prolyl 3-hydroxylase 2
PDGFA platelet-derived growth factor alpha polypeptide
PLK1 polo-like kinase 1
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
POSTN periostin, osteoblast specific factor
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPIF peptidylprolyl isomerase F
PRR11 proline rich 11
RAB25 RAB25, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SENP6 SUMO1/sentrin specific peptidase 6
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFPQ splicing factor proline/glutamine-rich
SFRP1 secreted frizzled-related protein 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SNRPE small nuclear ribonucleoprotein polypeptide E
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPATS2L spermatogenesis associated, serine-rich 2-like
SPDEF SAM pointed domain containing ETS transcription factor
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPRY2 sprouty homolog 2 (Drosophila)
SRP72 signal recognition particle 72kDa
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBX2 T-box 2
TFDP1 transcription factor Dp-1
TFF1 trefoil factor 1
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TMEM30B transmembrane protein 30B
TPBG trophoblast glycoprotein
TSKU tsukushi, small leucine rich proteoglycan
TUSC3 tumor suppressor candidate 3
UBE2E3 ubiquitin-conjugating enzyme E2E 3
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB1 zinc finger and BTB domain containing 1
ZNF721 zinc finger protein 721
Funding