BRD-K69840642_HDAC6 inhibitor ISOX_MDST8_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

245 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_MDST8_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT7 acyl-CoA thioesterase 7
ACTG2 actin, gamma 2, smooth muscle, enteric
ADARB1 adenosine deaminase, RNA-specific, B1
ADCY9 adenylate cyclase 9
ADRB2 adrenoceptor beta 2, surface
AGR2 anterior gradient 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGAP29 Rho GTPase activating protein 29
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP10A ATPase, class V, type 10A
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAMBI BMP and activin membrane-bound inhibitor
BPGM 2,3-bisphosphoglycerate mutase
C1QTNF3 C1q and tumor necrosis factor related protein 3
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLCA1 chloride channel accessory 1
CLDND1 claudin domain containing 1
CLIC4 chloride intracellular channel 4
COMP cartilage oligomeric matrix protein
CORO1A coronin, actin binding protein, 1A
CORO1C coronin, actin binding protein, 1C
CPD carboxypeptidase D
CTH cystathionine gamma-lyase
CTR9 CTR9, Paf1/RNA polymerase II complex component
CYB5R1 cytochrome b5 reductase 1
CYLD cylindromatosis (turban tumor syndrome)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DSTN destrin (actin depolymerizing factor)
EFHD1 EF-hand domain family, member D1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
FAM117A family with sequence similarity 117, member A
FBLN5 fibulin 5
FOXO4 forkhead box O4
FZD7 frizzled class receptor 7
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GLRX glutaredoxin (thioltransferase)
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
HAPLN1 hyaluronan and proteoglycan link protein 1
HEBP1 heme binding protein 1
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
IGFBP3 insulin-like growth factor binding protein 3
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
JAG1 jagged 1
KCTD5 potassium channel tetramerization domain containing 5
KIAA0226L KIAA0226-like
KRT19 keratin 19, type I
LAMC2 laminin, gamma 2
LAPTM5 lysosomal protein transmembrane 5
LCN2 lipocalin 2
LTA4H leukotriene A4 hydrolase
MAP7 microtubule-associated protein 7
MBP myelin basic protein
MCAM melanoma cell adhesion molecule
MEF2C myocyte enhancer factor 2C
MGST3 microsomal glutathione S-transferase 3
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLF1 myeloid leukemia factor 1
MPC2 mitochondrial pyruvate carrier 2
MSRB1 methionine sulfoxide reductase B1
MYB v-myb avian myeloblastosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NOSIP nitric oxide synthase interacting protein
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFM4 olfactomedin 4
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDPK1 3-phosphoinositide dependent protein kinase 1
PLA2G15 phospholipase A2, group XV
PLCB4 phospholipase C, beta 4
PLS1 plastin 1
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PRDX2 peroxiredoxin 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PROM1 prominin 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB31 RAB31, member RAS oncogene family
RAD9A RAD9 homolog A (S. pombe)
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
ROGDI rogdi homolog (Drosophila)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SCPEP1 serine carboxypeptidase 1
SEPT4 septin 4
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIK1 salt-inducible kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMAD7 SMAD family member 7
SPP1 secreted phosphoprotein 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRGN serglycin
STK17A serine/threonine kinase 17a
STK38 serine/threonine kinase 38
TBPL1 TBP-like 1
TIMP3 TIMP metallopeptidase inhibitor 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOB1 transducer of ERBB2, 1
TPD52L1 tumor protein D52-like 1
TPM2 tropomyosin 2 (beta)
TPST2 tyrosylprotein sulfotransferase 2
TSPAN13 tetraspanin 13
TST thiosulfate sulfurtransferase (rhodanese)
TUFT1 tuftelin 1
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF331 zinc finger protein 331
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AES amino-terminal enhancer of split
ALCAM activated leukocyte cell adhesion molecule
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP9 aquaporin 9
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
AURKA aurora kinase A
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BHLHE41 basic helix-loop-helix family, member e41
CALML5 calmodulin-like 5
CBR3 carbonyl reductase 3
CCDC86 coiled-coil domain containing 86
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CLIC2 chloride intracellular channel 2
CXCL9 chemokine (C-X-C motif) ligand 9
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DKK1 dickkopf WNT signaling pathway inhibitor 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
EREG epiregulin
FADS1 fatty acid desaturase 1
FAM57A family with sequence similarity 57, member A
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GABPB1 GA binding protein transcription factor, beta subunit 1
GBP1 guanylate binding protein 1, interferon-inducible
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPM6B glycoprotein M6B
GPX2 glutathione peroxidase 2
GRWD1 glutamate-rich WD repeat containing 1
GSAP gamma-secretase activating protein
GSTT1 glutathione S-transferase theta 1
HMGA2 high mobility group AT-hook 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGFBP6 insulin-like growth factor binding protein 6
IL1B interleukin 1, beta
IRAK1 interleukin-1 receptor-associated kinase 1
ISG20 interferon stimulated exonuclease gene 20kDa
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KEAP1 kelch-like ECH-associated protein 1
KIF18B kinesin family member 18B
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KYNU kynureninase
LPL lipoprotein lipase
LTF lactotransferrin
LYZ lysozyme
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM5 minichromosome maintenance complex component 5
MCTP1 multiple C2 domains, transmembrane 1
MICALL1 MICAL-like 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MME membrane metallo-endopeptidase
MRPL15 mitochondrial ribosomal protein L15
NBN nibrin
NES nestin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID1 nidogen 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMI N-myc (and STAT) interactor
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PGC progastricsin (pepsinogen C)
PIR pirin (iron-binding nuclear protein)
PLAGL1 pleiomorphic adenoma gene-like 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PON2 paraoxonase 2
POSTN periostin, osteoblast specific factor
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
RAD23B RAD23 homolog B (S. cerevisiae)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPS27L ribosomal protein S27-like
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMAD1 SMAD family member 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRY2 sprouty homolog 2 (Drosophila)
SQLE squalene epoxidase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLK1 tousled-like kinase 1
TMEM100 transmembrane protein 100
TNS3 tensin 3
TRIM29 tripartite motif containing 29
TYRP1 tyrosinase-related protein 1
UBE2E1 ubiquitin-conjugating enzyme E2E 1
WNT5A wingless-type MMTV integration site family, member 5A
ZMYND8 zinc finger, MYND-type containing 8
ZNF512B zinc finger protein 512B
Funding