BRD-K69840642_HDAC6 inhibitor ISOX_NCIH2073_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

218 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_NCIH2073_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABAT 4-aminobutyrate aminotransferase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDOC aldolase C, fructose-bisphosphate
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMDHD2 amidohydrolase domain containing 2
ARL3 ADP-ribosylation factor-like 3
ASMTL acetylserotonin O-methyltransferase-like
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BIK BCL2-interacting killer (apoptosis-inducing)
C9ORF16 chromosome 9 open reading frame 16
CA2 carbonic anhydrase II
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CD24 CD24 molecule
CD9 CD9 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CLDN3 claudin 3
CLIC4 chloride intracellular channel 4
CORO1A coronin, actin binding protein, 1A
CYFIP2 cytoplasmic FMR1 interacting protein 2
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUSP14 dual specificity phosphatase 14
EFHD1 EF-hand domain family, member D1
FAM117A family with sequence similarity 117, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXO4 forkhead box O4
GABARAPL2 GABA(A) receptor-associated protein-like 2
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GRN granulin
GSN gelsolin
HMG20B high mobility group 20B
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGHM immunoglobulin heavy constant mu
IL17RB interleukin 17 receptor B
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INHBA inhibin, beta A
IQCG IQ motif containing G
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
LGMN legumain
MAGEB2 melanoma antigen family B2
MAP7 microtubule-associated protein 7
MLEC malectin
MNAT1 MNAT CDK-activating kinase assembly factor 1
MSRB2 methionine sulfoxide reductase B2
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1M metallothionein 1M
MT1X metallothionein 1X
MYB v-myb avian myeloblastosis viral oncogene homolog
NEBL nebulette
NELL2 NEL-like 2 (chicken)
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
OPTN optineurin
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLA2G15 phospholipase A2, group XV
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RIMS3 regulating synaptic membrane exocytosis 3
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RTN2 reticulon 2
RTN3 reticulon 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMYD3 SET and MYND domain containing 3
SOX11 SRY (sex determining region Y)-box 11
STXBP1 syntaxin binding protein 1
TBXA2R thromboxane A2 receptor
TFF3 trefoil factor 3 (intestinal)
TIMP3 TIMP metallopeptidase inhibitor 3
TMPRSS3 transmembrane protease, serine 3
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VNN1 vanin 1
WDTC1 WD and tetratricopeptide repeats 1
WFS1 Wolfram syndrome 1 (wolframin)
ZSWIM8 zinc finger, SWIM-type containing 8

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADORA2B adenosine A2b receptor
AHNAK2 AHNAK nucleoprotein 2
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA1 annexin A1
ANXA2 annexin A2
ATF1 activating transcription factor 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C2CD5 C2 calcium-dependent domain containing 5
C6ORF62 chromosome 6 open reading frame 62
CAPN2 calpain 2, (m/II) large subunit
CAST calpastatin
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPT dermatopontin
DPYD dihydropyrimidine dehydrogenase
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EFS embryonal Fyn-associated substrate
EGFR epidermal growth factor receptor
EGR2 early growth response 2
EIF5A eukaryotic translation initiation factor 5A
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EMP3 epithelial membrane protein 3
FAM57A family with sequence similarity 57, member A
FAM69A family with sequence similarity 69, member A
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GDF15 growth differentiation factor 15
GLIPR1 GLI pathogenesis-related 1
GNAS GNAS complex locus
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPX2 glutathione peroxidase 2
GSPT2 G1 to S phase transition 2
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOPX HOP homeobox
HOXB7 homeobox B7
IFRD2 interferon-related developmental regulator 2
IGFBP7 insulin-like growth factor binding protein 7
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MDK midkine (neurite growth-promoting factor 2)
MEIS2 Meis homeobox 2
METTL1 methyltransferase like 1
MRPL15 mitochondrial ribosomal protein L15
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
NBN nibrin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PDGFA platelet-derived growth factor alpha polypeptide
PDGFD platelet derived growth factor D
PIR pirin (iron-binding nuclear protein)
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PTX3 pentraxin 3, long
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS5 regulator of G-protein signaling 5
RPS27L ribosomal protein S27-like
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A10 S100 calcium binding protein A10
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC35F2 solute carrier family 35, member F2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SPRY2 sprouty homolog 2 (Drosophila)
SQSTM1 sequestosome 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLK1 tousled-like kinase 1
TM4SF1 transmembrane 4 L six family member 1
TMX4 thioredoxin-related transmembrane protein 4
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TSKU tsukushi, small leucine rich proteoglycan
TUBB tubulin, beta class I
TXNDC9 thioredoxin domain containing 9
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP22 ubiquitin specific peptidase 22
VWF von Willebrand factor
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB20 zinc finger and BTB domain containing 20
ZBTB38 zinc finger and BTB domain containing 38
ZNF512B zinc finger protein 512B
Funding