BRD-K69840642_HDAC6 inhibitor ISOX_NOMO1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

168 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_NOMO1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOC aldolase C, fructose-bisphosphate
ANKRD46 ankyrin repeat domain 46
ANXA6 annexin A6
ARHGAP29 Rho GTPase activating protein 29
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAD BCL2-associated agonist of cell death
BCL2A1 BCL2-related protein A1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPHL biphenyl hydrolase-like (serine hydrolase)
C3ORF52 chromosome 3 open reading frame 52
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCL20 chemokine (C-C motif) ligand 20
CETN2 centrin, EF-hand protein, 2
CGRRF1 cell growth regulator with ring finger domain 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CLDN10 claudin 10
CLU clusterin
CPNE3 copine III
CRLF1 cytokine receptor-like factor 1
CYB5A cytochrome b5 type A (microsomal)
CYFIP2 cytoplasmic FMR1 interacting protein 2
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSE dermatan sulfate epimerase
DSTN destrin (actin depolymerizing factor)
DUSP5 dual specificity phosphatase 5
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ESYT1 extended synaptotagmin-like protein 1
FAM50A family with sequence similarity 50, member A
FKBP1B FK506 binding protein 1B, 12.6 kDa
G0S2 G0/G1 switch 2
GCH1 GTP cyclohydrolase 1
GSDMB gasdermin B
GSTM3 glutathione S-transferase mu 3 (brain)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HOXC6 homeobox C6
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA1A heat shock 70kDa protein 1A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFT57 intraflagellar transport 57
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
KCNK3 potassium channel, two pore domain subfamily K, member 3
L1CAM L1 cell adhesion molecule
MCAM melanoma cell adhesion molecule
METRN meteorin, glial cell differentiation regulator
MLF1 myeloid leukemia factor 1
MMD monocyte to macrophage differentiation-associated
MTERF3 mitochondrial transcription termination factor 3
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXRA7 matrix-remodelling associated 7
NLRP2 NLR family, pyrin domain containing 2
NME7 NME/NM23 family member 7
NMT2 N-myristoyltransferase 2
NOSIP nitric oxide synthase interacting protein
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OAT ornithine aminotransferase
PAM peptidylglycine alpha-amidating monooxygenase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCOLCE2 procollagen C-endopeptidase enhancer 2
PEG10 paternally expressed 10
PLA2G15 phospholipase A2, group XV
PLA2G16 phospholipase A2, group XVI
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRUNE2 prune homolog 2 (Drosophila)
PSPH phosphoserine phosphatase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RBP4 retinol binding protein 4, plasma
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RTN3 reticulon 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
STX1A syntaxin 1A (brain)
TES testin LIM domain protein
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMSB15A thymosin beta 15a
TOB1 transducer of ERBB2, 1
TPD52 tumor protein D52
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGCG UDP-glucose ceramide glucosyltransferase
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ALCAM activated leukocyte cell adhesion molecule
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA1 annexin A1
APOLD1 apolipoprotein L domain containing 1
ATF5 activating transcription factor 5
AZU1 azurocidin 1
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BPTF bromodomain PHD finger transcription factor
CCL2 chemokine (C-C motif) ligand 2
CD9 CD9 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CXCR4 chemokine (C-X-C motif) receptor 4
ELF1 E74-like factor 1 (ets domain transcription factor)
EMP3 epithelial membrane protein 3
EVI2B ecotropic viral integration site 2B
EVL Enah/Vasp-like
EXOSC4 exosome component 4
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
GLIPR1 GLI pathogenesis-related 1
GPM6B glycoprotein M6B
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KAT6B K(lysine) acetyltransferase 6B
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LMO2 LIM domain only 2 (rhombotin-like 1)
LXN latexin
LYPLA1 lysophospholipase I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGST2 microsomal glutathione S-transferase 2
MICALL1 MICAL-like 1
MRPL23 mitochondrial ribosomal protein L23
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NMI N-myc (and STAT) interactor
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PECAM1 platelet/endothelial cell adhesion molecule 1
PICALM phosphatidylinositol binding clathrin assembly protein
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PYCARD PYD and CARD domain containing
RNH1 ribonuclease/angiogenin inhibitor 1
RSL1D1 ribosomal L1 domain containing 1
SCAND1 SCAN domain containing 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SOX17 SRY (sex determining region Y)-box 17
SPARCL1 SPARC-like 1 (hevin)
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STAG2 stromal antigen 2
STXBP2 syntaxin binding protein 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
THBS1 thrombospondin 1
WIPF1 WAS/WASL interacting protein family, member 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36L2 ZFP36 ring finger protein-like 2
Funding