BRD-K69840642_HDAC6 inhibitor ISOX_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

393 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOA aldolase A, fructose-bisphosphate
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
AP3D1 adaptor-related protein complex 3, delta 1 subunit
ARF3 ADP-ribosylation factor 3
ARHGAP29 Rho GTPase activating protein 29
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
ATG2A autophagy related 2A
ATP10D ATPase, class V, type 10D
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
BAMBI BMP and activin membrane-bound inhibitor
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
C2CD2L C2CD2-like
C8ORF4 chromosome 8 open reading frame 4
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CAPZB capping protein (actin filament) muscle Z-line, beta
CCND3 cyclin D3
CCNG2 cyclin G2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHN2 chimerin 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN3 claudin 3
CLPTM1 cleft lip and palate associated transmembrane protein 1
CORO1A coronin, actin binding protein, 1A
CPA3 carboxypeptidase A3 (mast cell)
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYLD cylindromatosis (turban tumor syndrome)
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DGKA diacylglycerol kinase, alpha 80kDa
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDNRB endothelin receptor type B
EFNB2 ephrin-B2
EGR3 early growth response 3
EIF5B eukaryotic translation initiation factor 5B
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
FABP1 fatty acid binding protein 1, liver
FADS3 fatty acid desaturase 3
FAM117A family with sequence similarity 117, member A
FLRT3 fibronectin leucine rich transmembrane protein 3
FNBP1L formin binding protein 1-like
FOXO4 forkhead box O4
FYN FYN proto-oncogene, Src family tyrosine kinase
G6PD glucose-6-phosphate dehydrogenase
GABARAPL2 GABA(A) receptor-associated protein-like 2
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GDI1 GDP dissociation inhibitor 1
GM2A GM2 ganglioside activator
GPM6B glycoprotein M6B
GSDMB gasdermin B
H1F0 H1 histone family, member 0
HECA headcase homolog (Drosophila)
HIC2 hypermethylated in cancer 2
HIST1H3H histone cluster 1, H3h
HMOX1 heme oxygenase 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFT27 intraflagellar transport 27
IGF2R insulin-like growth factor 2 receptor
IGHM immunoglobulin heavy constant mu
IL1B interleukin 1, beta
INHBA inhibin, beta A
INSR insulin receptor
ITGA8 integrin, alpha 8
ITM2C integral membrane protein 2C
JAG1 jagged 1
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIAA0040 KIAA0040
KIF5C kinesin family member 5C
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
L1CAM L1 cell adhesion molecule
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LPIN1 lipin 1
LRRN3 leucine rich repeat neuronal 3
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAL mal, T-cell differentiation protein
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARK4 MAP/microtubule affinity-regulating kinase 4
MCOLN1 mucolipin 1
MIR22HG MIR22 host gene
MVP major vault protein
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NIT1 nitrilase 1
NPTX2 neuronal pentraxin II
OLFM4 olfactomedin 4
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDH9 protocadherin 9
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDPK1 3-phosphoinositide dependent protein kinase 1
PEG10 paternally expressed 10
PID1 phosphotyrosine interaction domain containing 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLA2G15 phospholipase A2, group XV
PLIN2 perilipin 2
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRKCB protein kinase C, beta
PROM1 prominin 1
PRSS3 protease, serine, 3
PSAP prosaposin
PTN pleiotrophin
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPRD protein tyrosine phosphatase, receptor type, D
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAP1GAP RAP1 GTPase activating protein
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
REG1B regenerating islet-derived 1 beta
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
RSRP1 arginine/serine-rich protein 1
RTN2 reticulon 2
RUNX3 runt-related transcription factor 3
SDC3 syndecan 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGCE sarcoglycan, epsilon
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIK1 salt-inducible kinase 1
SKAP2 src kinase associated phosphoprotein 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SNAI2 snail family zinc finger 2
SND1 staphylococcal nuclease and tudor domain containing 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPON1 spondin 1, extracellular matrix protein
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SPTSSA serine palmitoyltransferase, small subunit A
SST somatostatin
STAT1 signal transducer and activator of transcription 1, 91kDa
STX7 syntaxin 7
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBX3 T-box 3
THEMIS2 thymocyte selection associated family member 2
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKT transketolase
TOB1 transducer of ERBB2, 1
TPP1 tripeptidyl peptidase I
TSC22D2 TSC22 domain family, member 2
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VNN1 vanin 1
WASL Wiskott-Aldrich syndrome-like
WIPI1 WD repeat domain, phosphoinositide interacting 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZBTB18 zinc finger and BTB domain containing 18
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AIM1 absent in melanoma 1
AK4 adenylate kinase 4
ALCAM activated leukocyte cell adhesion molecule
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA1 annexin A1
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
AURKB aurora kinase B
AZU1 azurocidin 1
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BID BH3 interacting domain death agonist
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CASD1 CAS1 domain containing 1
CBR3 carbonyl reductase 3
CCDC91 coiled-coil domain containing 91
CDC25A cell division cycle 25A
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CENPU centromere protein U
CFH complement factor H
CHEK1 checkpoint kinase 1
CIRBP cold inducible RNA binding protein
COCH cochlin
COL4A2 collagen, type IV, alpha 2
COL5A2 collagen, type V, alpha 2
COL6A2 collagen, type VI, alpha 2
COMT catechol-O-methyltransferase
CST3 cystatin C
CTPS1 CTP synthase 1
CXCL8 chemokine (C-X-C motif) ligand 8
DCTD dCMP deaminase
DEK DEK proto-oncogene
DLG5 discs, large homolog 5 (Drosophila)
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DPYD dihydropyrimidine dehydrogenase
DRAM1 DNA-damage regulated autophagy modulator 1
DUT deoxyuridine triphosphatase
ECT2 epithelial cell transforming 2
ELP5 elongator acetyltransferase complex subunit 5
ENDOG endonuclease G
ENOSF1 enolase superfamily member 1
EPCAM epithelial cell adhesion molecule
ESR1 estrogen receptor 1
FAIM Fas apoptotic inhibitory molecule
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FBN1 fibrillin 1
FBP1 fructose-1,6-bisphosphatase 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FOXM1 forkhead box M1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GBE1 glucan (1,4-alpha-), branching enzyme 1
GCHFR GTP cyclohydrolase I feedback regulator
GNPDA1 glucosamine-6-phosphate deaminase 1
GOLM1 golgi membrane protein 1
GSAP gamma-secretase activating protein
GTF3A general transcription factor IIIA
HDDC2 HD domain containing 2
HDGFRP3 hepatoma-derived growth factor, related protein 3
HMGA2 high mobility group AT-hook 2
HMGB1 high mobility group box 1
HOXB2 homeobox B2
HOXB7 homeobox B7
HSPB1 heat shock 27kDa protein 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP6 insulin-like growth factor binding protein 6
ING3 inhibitor of growth family, member 3
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0101 KIAA0101
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT18 keratin 18, type I
KRT5 keratin 5, type II
KYNU kynureninase
LDLR low density lipoprotein receptor
LMNB1 lamin B1
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
LY96 lymphocyte antigen 96
LYZ lysozyme
MANSC1 MANSC domain containing 1
MAPK13 mitogen-activated protein kinase 13
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MDK midkine (neurite growth-promoting factor 2)
MLPH melanophilin
MPDU1 mannose-P-dolichol utilization defect 1
MRPS35 mitochondrial ribosomal protein S35
MSRA methionine sulfoxide reductase A
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
MYO5C myosin VC
MYOF myoferlin
MZT2A mitotic spindle organizing protein 2A
NBN nibrin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NKX3-1 NK3 homeobox 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMI N-myc (and STAT) interactor
NNT nicotinamide nucleotide transhydrogenase
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPEPL1 aminopeptidase-like 1
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15
NUPR1 nuclear protein, transcriptional regulator, 1
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAIP1 poly(A) binding protein interacting protein 1
PCCB propionyl CoA carboxylase, beta polypeptide
PDE4A phosphodiesterase 4A, cAMP-specific
PEMT phosphatidylethanolamine N-methyltransferase
PHF11 PHD finger protein 11
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PIP prolactin-induced protein
PLBD1 phospholipase B domain containing 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
PLTP phospholipid transfer protein
PMF1 polyamine-modulated factor 1
PMP22 peripheral myelin protein 22
PPAP2C phosphatidic acid phosphatase type 2C
PRNP prion protein
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PTGIS prostaglandin I2 (prostacyclin) synthase
RAD51AP1 RAD51 associated protein 1
RAI14 retinoic acid induced 14
RBBP8 retinoblastoma binding protein 8
RBM3 RNA binding motif (RNP1, RRM) protein 3
RCN1 reticulocalbin 1, EF-hand calcium binding domain
REEP5 receptor accessory protein 5
REPIN1 replication initiator 1
RGCC regulator of cell cycle
RNH1 ribonuclease/angiogenin inhibitor 1
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
S100A7 S100 calcium binding protein A7
SCCPDH saccharopine dehydrogenase (putative)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCRN1 secernin 1
SENP6 SUMO1/sentrin specific peptidase 6
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC35F2 solute carrier family 35, member F2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMYD2 SET and MYND domain containing 2
SNRPE small nuclear ribonucleoprotein polypeptide E
SORBS2 sorbin and SH3 domain containing 2
SORBS3 sorbin and SH3 domain containing 3
SPAG7 sperm associated antigen 7
SPDEF SAM pointed domain containing ETS transcription factor
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRY2 sprouty homolog 2 (Drosophila)
SREBF1 sterol regulatory element binding transcription factor 1
ST7 suppression of tumorigenicity 7
STAG1 stromal antigen 1
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
STEAP3 STEAP family member 3, metalloreductase
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SUMO3 small ubiquitin-like modifier 3
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TFDP1 transcription factor Dp-1
TFF3 trefoil factor 3 (intestinal)
TGM2 transglutaminase 2
TIMELESS timeless circadian clock
TLK1 tousled-like kinase 1
TMEM5 transmembrane protein 5
TMPO thymopoietin
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOR1A torsin family 1, member A (torsin A)
TP63 tumor protein p63
TRIM29 tripartite motif containing 29
TRIP13 thyroid hormone receptor interactor 13
TRMT5 tRNA methyltransferase 5
TSPAN6 tetraspanin 6
TTC39A tetratricopeptide repeat domain 39A
TUBB6 tubulin, beta 6 class V
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UFC1 ubiquitin-fold modifier conjugating enzyme 1
VBP1 von Hippel-Lindau binding protein 1
WFDC2 WAP four-disulfide core domain 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZMYND11 zinc finger, MYND-type containing 11
ZWINT ZW10 interacting kinetochore protein
Funding