BRD-K69840642_HDAC6 inhibitor ISOX_RKO_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_RKO_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADD3 adducin 3 (gamma)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOC aldolase C, fructose-bisphosphate
ARHGAP29 Rho GTPase activating protein 29
ASCL1 achaete-scute family bHLH transcription factor 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
CA12 carbonic anhydrase XII
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CD24 CD24 molecule
CDC20 cell division cycle 20
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN3 claudin 3
CNN3 calponin 3, acidic
CORO1A coronin, actin binding protein, 1A
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSRP1 cysteine and glycine-rich protein 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCN decorin
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
FAM107A family with sequence similarity 107, member A
FOLR1 folate receptor 1 (adult)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAS GNAS complex locus
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX3 glutathione peroxidase 3
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMOX1 heme oxygenase 1
HSDL2 hydroxysteroid dehydrogenase like 2
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL17RB interleukin 17 receptor B
IL32 interleukin 32
ITM2A integral membrane protein 2A
KIAA0226L KIAA0226-like
KRT7 keratin 7, type II
LIN37 lin-37 DREAM MuvB core complex component
LIPG lipase, endothelial
LPIN1 lipin 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MPC1 mitochondrial pyruvate carrier 1
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MVP major vault protein
NEBL nebulette
NOSIP nitric oxide synthase interacting protein
OLFM4 olfactomedin 4
PCDH9 protocadherin 9
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG10 paternally expressed 10
PLA2G15 phospholipase A2, group XV
PLAT plasminogen activator, tissue
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
RIMS3 regulating synaptic membrane exocytosis 3
S100A14 S100 calcium binding protein A14
SCG2 secretogranin II
SCGB1D2 secretoglobin, family 1D, member 2
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFRP1 secreted frizzled-related protein 1
SGCE sarcoglycan, epsilon
SNN stannin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TCL1A T-cell leukemia/lymphoma 1A
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSPAN13 tetraspanin 13
TUBA4A tubulin, alpha 4a
UGCG UDP-glucose ceramide glucosyltransferase
VLDLR very low density lipoprotein receptor
WDR61 WD repeat domain 61
WT1 Wilms tumor 1
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ADM adrenomedullin
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA1 annexin A1
APOLD1 apolipoprotein L domain containing 1
ATF5 activating transcription factor 5
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
C2CD5 C2 calcium-dependent domain containing 5
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CCND2 cyclin D2
CD93 CD93 molecule
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CYFIP1 cytoplasmic FMR1 interacting protein 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EMP3 epithelial membrane protein 3
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM57A family with sequence similarity 57, member A
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
GBE1 glucan (1,4-alpha-), branching enzyme 1
GSAP gamma-secretase activating protein
GSTO1 glutathione S-transferase omega 1
GUSB glucuronidase, beta
HOXC10 homeobox C10
IGFBP6 insulin-like growth factor binding protein 6
IRAK1 interleukin-1 receptor-associated kinase 1
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
LOC100286895 cell division cycle 27 homolog pseudogene
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MET MET proto-oncogene, receptor tyrosine kinase
MICALL1 MICAL-like 1
MMP9 matrix metallopeptidase 9
MXRA5 matrix-remodelling associated 5
NRIP1 nuclear receptor interacting protein 1
OBSL1 obscurin-like 1
PLSCR3 phospholipid scramblase 3
PPAP2B phosphatidic acid phosphatase type 2B
RIN3 Ras and Rab interactor 3
RREB1 ras responsive element binding protein 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPRED2 sprouty-related, EVH1 domain containing 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TNS3 tensin 3
TSPAN8 tetraspanin 8
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UFC1 ubiquitin-fold modifier conjugating enzyme 1
USP22 ubiquitin specific peptidase 22
VEGFA vascular endothelial growth factor A
YBX3 Y box binding protein 3
ZNF395 zinc finger protein 395
Funding