BRD-K69840642_HDAC6 inhibitor ISOX_RMUGS_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

195 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_RMUGS_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACAD8 acyl-CoA dehydrogenase family, member 8
ACOT7 acyl-CoA thioesterase 7
ANOS1 anosmin 1
APLP2 amyloid beta (A4) precursor-like protein 2
ARHGAP32 Rho GTPase activating protein 32
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARID4B AT rich interactive domain 4B (RBP1-like)
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASMTL acetylserotonin O-methyltransferase-like
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAMBI BMP and activin membrane-bound inhibitor
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC3 baculoviral IAP repeat containing 3
BLVRA biliverdin reductase A
BZW2 basic leucine zipper and W2 domains 2
CA2 carbonic anhydrase II
CALCOCO2 calcium binding and coiled-coil domain 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNA1 cyclin A1
CCND3 cyclin D3
CD9 CD9 molecule
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CKB creatine kinase, brain
CLU clusterin
CPD carboxypeptidase D
CRIP1 cysteine-rich protein 1 (intestinal)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTH cystathionine gamma-lyase
CYB5R1 cytochrome b5 reductase 1
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
ELOVL5 ELOVL fatty acid elongase 5
ENOPH1 enolase-phosphatase 1
FABP7 fatty acid binding protein 7, brain
FBLN5 fibulin 5
FCGBP Fc fragment of IgG binding protein
FGFR3 fibroblast growth factor receptor 3
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPD1L glycerol-3-phosphate dehydrogenase 1-like
HMOX1 heme oxygenase 1
HPCAL1 hippocalcin-like 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFT57 intraflagellar transport 57
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
ITGA6 integrin, alpha 6
ITM2A integral membrane protein 2A
KLF4 Kruppel-like factor 4 (gut)
L1CAM L1 cell adhesion molecule
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
LEPROTL1 leptin receptor overlapping transcript-like 1
LPIN1 lipin 1
LSR lipolysis stimulated lipoprotein receptor
MAB21L2 mab-21-like 2 (C. elegans)
MAN2A1 mannosidase, alpha, class 2A, member 1
MSMO1 methylsterol monooxygenase 1
NAMPT nicotinamide phosphoribosyltransferase
NEU1 sialidase 1 (lysosomal sialidase)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NLGN4X neuroligin 4, X-linked
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
OAT ornithine aminotransferase
OLFM1 olfactomedin 1
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCDH9 protocadherin 9
PCSK5 proprotein convertase subtilisin/kexin type 5
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G15 phospholipase A2, group XV
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PNMA2 paraneoplastic Ma antigen 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRKCZ protein kinase C, zeta
PTGDS prostaglandin D2 synthase 21kDa (brain)
RABAC1 Rab acceptor 1 (prenylated)
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RGS10 regulator of G-protein signaling 10
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SCG2 secretogranin II
SCPEP1 serine carboxypeptidase 1
SEPP1 selenoprotein P, plasma, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
TBPL1 TBP-like 1
THY1 Thy-1 cell surface antigen
TIAM1 T-cell lymphoma invasion and metastasis 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM41B transmembrane protein 41B
TOB1 transducer of ERBB2, 1
TPD52 tumor protein D52
TPST2 tyrosylprotein sulfotransferase 2
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADIPOQ adiponectin, C1Q and collagen domain containing
AMIGO2 adhesion molecule with Ig-like domain 2
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ATF5 activating transcription factor 5
AUTS2 autism susceptibility candidate 2
BPIFA1 BPI fold containing family A, member 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
DACH1 dachshund family transcription factor 1
DICER1 dicer 1, ribonuclease type III
EDN1 endothelin 1
EIF5A eukaryotic translation initiation factor 5A
ERBB4 erb-b2 receptor tyrosine kinase 4
HDGF hepatoma-derived growth factor
HMGA2 high mobility group AT-hook 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
KEAP1 kelch-like ECH-associated protein 1
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LPAR6 lysophosphatidic acid receptor 6
LPL lipoprotein lipase
LTF lactotransferrin
MBNL1 muscleblind-like splicing regulator 1
MEIS2 Meis homeobox 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PARP2 poly (ADP-ribose) polymerase 2
PDE4C phosphodiesterase 4C, cAMP-specific
PLAGL1 pleiomorphic adenoma gene-like 1
PLIN1 perilipin 1
PLK1 polo-like kinase 1
POU2AF1 POU class 2 associating factor 1
PRR11 proline rich 11
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
S100A2 S100 calcium binding protein A2
SFRP1 secreted frizzled-related protein 1
SLPI secretory leukocyte peptidase inhibitor
SPRR3 small proline-rich protein 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TNPO1 transportin 1
UPK1B uroplakin 1B
USP34 ubiquitin specific peptidase 34
VGLL4 vestigial-like family member 4
VTCN1 V-set domain containing T cell activation inhibitor 1
XBP1 X-box binding protein 1
ZHX2 zinc fingers and homeoboxes 2
ZIC1 Zic family member 1
ZNF721 zinc finger protein 721
Funding