| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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173 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_SKLU1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein |
| AMFR | autocrine motility factor receptor, E3 ubiquitin protein ligase |
| ARHGAP32 | Rho GTPase activating protein 32 |
| BICD2 | bicaudal D homolog 2 (Drosophila) |
| C5AR1 | complement component 5a receptor 1 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
| CTSV | cathepsin V |
| CYBB | cytochrome b-245, beta polypeptide |
| CYTH1 | cytohesin 1 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 |
| DLK1 | delta-like 1 homolog (Drosophila) |
| DSTN | destrin (actin depolymerizing factor) |
| EDNRB | endothelin receptor type B |
| ELN | elastin |
| EMP2 | epithelial membrane protein 2 |
| ENOPH1 | enolase-phosphatase 1 |
| FHL1 | four and a half LIM domains 1 |
| FLNB | filamin B, beta |
| FOXO4 | forkhead box O4 |
| GCA | grancalcin, EF-hand calcium binding protein |
| GLRX | glutaredoxin (thioltransferase) |
| HEBP1 | heme binding protein 1 |
| HECA | headcase homolog (Drosophila) |
| HIP1R | huntingtin interacting protein 1 related |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) |
| HN1 | hematological and neurological expressed 1 |
| HSDL2 | hydroxysteroid dehydrogenase like 2 |
| HSPB8 | heat shock 22kDa protein 8 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 |
| IER3 | immediate early response 3 |
| IGSF3 | immunoglobulin superfamily, member 3 |
| IKBKAP | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 |
| INSIG1 | insulin induced gene 1 |
| ITGA6 | integrin, alpha 6 |
| ITM2A | integral membrane protein 2A |
| KCTD12 | potassium channel tetramerization domain containing 12 |
| KCTD5 | potassium channel tetramerization domain containing 5 |
| KIF1A | kinesin family member 1A |
| LIMCH1 | LIM and calponin homology domains 1 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 |
| LTA4H | leukotriene A4 hydrolase |
| MEGF9 | multiple EGF-like-domains 9 |
| MGP | matrix Gla protein |
| MN1 | meningioma (disrupted in balanced translocation) 1 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 |
| MXRA7 | matrix-remodelling associated 7 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) |
| NOSIP | nitric oxide synthase interacting protein |
| NPC1 | Niemann-Pick disease, type C1 |
| OSTF1 | osteoclast stimulating factor 1 |
| PCOLCE2 | procollagen C-endopeptidase enhancer 2 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 |
| PEG10 | paternally expressed 10 |
| PLA2G15 | phospholipase A2, group XV |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 |
| PLS1 | plastin 1 |
| PSPH | phosphoserine phosphatase |
| PTPRE | protein tyrosine phosphatase, receptor type, E |
| RAD9A | RAD9 homolog A (S. pombe) |
| RAP1GAP | RAP1 GTPase activating protein |
| RBP1 | retinol binding protein 1, cellular |
| RCAN1 | regulator of calcineurin 1 |
| REEP1 | receptor accessory protein 1 |
| RGS16 | regulator of G-protein signaling 16 |
| RHOB | ras homolog family member B |
| RRAGD | Ras-related GTP binding D |
| RTN3 | reticulon 3 |
| SEPT6 | septin 6 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 |
| SKAP2 | src kinase associated phosphoprotein 2 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 |
| SNN | stannin |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 |
| SRGN | serglycin |
| STXBP1 | syntaxin binding protein 1 |
| TBPL1 | TBP-like 1 |
| THBS2 | thrombospondin 2 |
| TLE4 | transducin-like enhancer of split 4 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 |
| TRAPPC4 | trafficking protein particle complex 4 |
| TRIM2 | tripartite motif containing 2 |
| VAT1 | vesicle amine transport 1 |
| WDR47 | WD repeat domain 47 |
| ZNF586 | zinc finger protein 586 |
| Symbol | Name |
|---|---|
| ADI1 | acireductone dioxygenase 1 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 |
| APOL3 | apolipoprotein L, 3 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa |
| ATF1 | activating transcription factor 1 |
| ATF5 | activating transcription factor 5 |
| BEX1 | brain expressed, X-linked 1 |
| BID | BH3 interacting domain death agonist |
| C6ORF62 | chromosome 6 open reading frame 62 |
| C8ORF4 | chromosome 8 open reading frame 4 |
| CA12 | carbonic anhydrase XII |
| CAMKK2 | calcium/calmodulin-dependent protein kinase kinase 2, beta |
| CBR3 | carbonyl reductase 3 |
| CCND1 | cyclin D1 |
| CFB | complement factor B |
| COG2 | component of oligomeric golgi complex 2 |
| COL4A6 | collagen, type IV, alpha 6 |
| CP | ceruloplasmin (ferroxidase) |
| CST3 | cystatin C |
| CXCL10 | chemokine (C-X-C motif) ligand 10 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 |
| DCTD | dCMP deaminase |
| EIF4B | eukaryotic translation initiation factor 4B |
| EIF5 | eukaryotic translation initiation factor 5 |
| EIF5A | eukaryotic translation initiation factor 5A |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 |
| FAM57A | family with sequence similarity 57, member A |
| FOSL1 | FOS-like antigen 1 |
| FOSL2 | FOS-like antigen 2 |
| GALNT7 | polypeptide N-acetylgalactosaminyltransferase 7 |
| GPATCH8 | G patch domain containing 8 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 |
| HMGA2 | high mobility group AT-hook 2 |
| IDO1 | indoleamine 2,3-dioxygenase 1 |
| KYNU | kynureninase |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
| MDK | midkine (neurite growth-promoting factor 2) |
| MEPCE | methylphosphate capping enzyme |
| MMP10 | matrix metallopeptidase 10 |
| MSLN | mesothelin |
| MSMB | microseminoprotein, beta- |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 |
| NPDC1 | neural proliferation, differentiation and control, 1 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 |
| PAN2 | PAN2 poly(A) specific ribonuclease subunit |
| PAX8 | paired box 8 |
| PI3 | peptidase inhibitor 3, skin-derived |
| PLK1 | polo-like kinase 1 |
| PON2 | paraoxonase 2 |
| PSCA | prostate stem cell antigen |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 |
| RCN1 | reticulocalbin 1, EF-hand calcium binding domain |
| RGCC | regulator of cell cycle |
| RPL10 | ribosomal protein L10 |
| RPL27A | ribosomal protein L27a |
| RPL37A | ribosomal protein L37a |
| RPL38 | ribosomal protein L38 |
| RPS11 | ribosomal protein S11 |
| SEC22B | SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) |
| SFRP1 | secreted frizzled-related protein 1 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 |
| SMAD4 | SMAD family member 4 |
| SOX4 | SRY (sex determining region Y)-box 4 |
| SRSF7 | serine/arginine-rich splicing factor 7 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) |
| TCERG1 | transcription elongation regulator 1 |
| TFF1 | trefoil factor 1 |
| TLK1 | tousled-like kinase 1 |
| TM9SF3 | transmembrane 9 superfamily member 3 |
| TSC22D1 | TSC22 domain family, member 1 |
| USE1 | unconventional SNARE in the ER 1 homolog (S. cerevisiae) |
| WNT5A | wingless-type MMTV integration site family, member 5A |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon |
| ZFP36L2 | ZFP36 ring finger protein-like 2 |
| ZHX2 | zinc fingers and homeoboxes 2 |
