| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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162 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_SKMEL28_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ABAT | 4-aminobutyrate aminotransferase |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 |
| ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) |
| ADCY9 | adenylate cyclase 9 |
| AKAP13 | A kinase (PRKA) anchor protein 13 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) |
| ARHGAP29 | Rho GTPase activating protein 29 |
| ASMTL | acetylserotonin O-methyltransferase-like |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide |
| BIRC3 | baculoviral IAP repeat containing 3 |
| CA2 | carbonic anhydrase II |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 |
| CAP2 | CAP, adenylate cyclase-associated protein, 2 (yeast) |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
| CLDND1 | claudin domain containing 1 |
| COL4A5 | collagen, type IV, alpha 5 |
| COTL1 | coactosin-like F-actin binding protein 1 |
| CPE | carboxypeptidase E |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 |
| DSP | desmoplakin |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 |
| EFNB2 | ephrin-B2 |
| EGR1 | early growth response 1 |
| EPAS1 | endothelial PAS domain protein 1 |
| FGB | fibrinogen beta chain |
| FGG | fibrinogen gamma chain |
| FNBP1L | formin binding protein 1-like |
| GLRX | glutaredoxin (thioltransferase) |
| HBB | hemoglobin, beta |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 |
| HMOX1 | heme oxygenase 1 |
| HSPA1A | heat shock 70kDa protein 1A |
| HSPA2 | heat shock 70kDa protein 2 |
| ICAM1 | intercellular adhesion molecule 1 |
| IER5 | immediate early response 5 |
| IFI27 | interferon, alpha-inducible protein 27 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 |
| IFT57 | intraflagellar transport 57 |
| IL17RB | interleukin 17 receptor B |
| IL32 | interleukin 32 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) |
| ITM2A | integral membrane protein 2A |
| KCTD12 | potassium channel tetramerization domain containing 12 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 |
| LSR | lipolysis stimulated lipoprotein receptor |
| MAOB | monoamine oxidase B |
| MAST2 | microtubule associated serine/threonine kinase 2 |
| MLF1 | myeloid leukemia factor 1 |
| MN1 | meningioma (disrupted in balanced translocation) 1 |
| MX1 | MX dynamin-like GTPase 1 |
| MYBPC1 | myosin binding protein C, slow type |
| NEB | nebulin |
| NELL2 | NEL-like 2 (chicken) |
| PALLD | palladin, cytoskeletal associated protein |
| PAM | peptidylglycine alpha-amidating monooxygenase |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 |
| PEG10 | paternally expressed 10 |
| PROM1 | prominin 1 |
| PTP4A3 | protein tyrosine phosphatase type IVA, member 3 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) |
| RBP1 | retinol binding protein 1, cellular |
| RBPMS | RNA binding protein with multiple splicing |
| RGCC | regulator of cell cycle |
| RGS16 | regulator of G-protein signaling 16 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 |
| SLC38A1 | solute carrier family 38, member 1 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 |
| SMYD3 | SET and MYND domain containing 3 |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) |
| STAT1 | signal transducer and activator of transcription 1, 91kDa |
| TIMP3 | TIMP metallopeptidase inhibitor 3 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase |
| TM4SF4 | transmembrane 4 L six family member 4 |
| TPD52L1 | tumor protein D52-like 1 |
| TRPS1 | trichorhinophalangeal syndrome I |
| VAMP1 | vesicle-associated membrane protein 1 (synaptobrevin 1) |
| WDTC1 | WD and tetratricopeptide repeats 1 |
| ZBTB16 | zinc finger and BTB domain containing 16 |
| Symbol | Name |
|---|---|
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit |
| AQP3 | aquaporin 3 (Gill blood group) |
| ATF1 | activating transcription factor 1 |
| AURKA | aurora kinase A |
| BEX1 | brain expressed, X-linked 1 |
| BHLHE41 | basic helix-loop-helix family, member e41 |
| CAPN3 | calpain 3, (p94) |
| CBR3 | carbonyl reductase 3 |
| CCL18 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) |
| CD24 | CD24 molecule |
| CDK5R1 | cyclin-dependent kinase 5, regulatory subunit 1 (p35) |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
| CELF2 | CUGBP, Elav-like family member 2 |
| CHL1 | cell adhesion molecule L1-like |
| CLTC | clathrin, heavy chain (Hc) |
| CTSH | cathepsin H |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 |
| DCLK1 | doublecortin-like kinase 1 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa |
| EXOSC4 | exosome component 4 |
| FABP7 | fatty acid binding protein 7, brain |
| FAM57A | family with sequence similarity 57, member A |
| FSTL1 | follistatin-like 1 |
| FXYD3 | FXYD domain containing ion transport regulator 3 |
| GPNMB | glycoprotein (transmembrane) nmb |
| GSTO1 | glutathione S-transferase omega 1 |
| GYG2 | glycogenin 2 |
| HAS2 | hyaluronan synthase 2 |
| HMGA2 | high mobility group AT-hook 2 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) |
| KEAP1 | kelch-like ECH-associated protein 1 |
| KRT10 | keratin 10, type I |
| KRT14 | keratin 14, type I |
| KRT5 | keratin 5, type II |
| LMNB1 | lamin B1 |
| LTF | lactotransferrin |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 |
| MFAP5 | microfibrillar associated protein 5 |
| MLANA | melan-A |
| MLPH | melanophilin |
| MOK | MOK protein kinase |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog |
| NUSAP1 | nucleolar and spindle associated protein 1 |
| PAN2 | PAN2 poly(A) specific ribonuclease subunit |
| PARP2 | poly (ADP-ribose) polymerase 2 |
| PDE4DIP | phosphodiesterase 4D interacting protein |
| PLK1 | polo-like kinase 1 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma |
| PSCA | prostate stem cell antigen |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 |
| PTX3 | pentraxin 3, long |
| QDPR | quinoid dihydropteridine reductase |
| RFC2 | replication factor C (activator 1) 2, 40kDa |
| RTN4 | reticulon 4 |
| SCGB2A1 | secretoglobin, family 2A, member 1 |
| SCYL3 | SCY1-like 3 (S. cerevisiae) |
| SH3BP4 | SH3-domain binding protein 4 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 |
| SLC2A10 | solute carrier family 2 (facilitated glucose transporter), member 10 |
| SNAI2 | snail family zinc finger 2 |
| SORD | sorbitol dehydrogenase |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 |
| SRPX | sushi-repeat containing protein, X-linked |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 |
| STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced |
| SUMO3 | small ubiquitin-like modifier 3 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) |
| TNC | tenascin C |
| TRIB2 | tribbles pseudokinase 2 |
| TRIM2 | tripartite motif containing 2 |
| TSPAN8 | tetraspanin 8 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 |
| VAT1 | vesicle amine transport 1 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 |
| ZMYND8 | zinc finger, MYND-type containing 8 |
