BRD-K69840642_HDAC6 inhibitor ISOX_SNGM_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

171 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_SNGM_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
C10ORF10 chromosome 10 open reading frame 10
CALU calumenin
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CDK19 cyclin-dependent kinase 19
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN1 chimerin 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CNN3 calponin 3, acidic
CRIP2 cysteine-rich protein 2
CST6 cystatin E/M
DHRS2 dehydrogenase/reductase (SDR family) member 2
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM117A family with sequence similarity 117, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FKBP1A FK506 binding protein 1A, 12kDa
FOLR1 folate receptor 1 (adult)
GLRX glutaredoxin (thioltransferase)
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GOLGA7 golgin A7
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
ITM2A integral membrane protein 2A
KCNK3 potassium channel, two pore domain subfamily K, member 3
LBH limb bud and heart development
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MCOLN1 mucolipin 1
METRN meteorin, glial cell differentiation regulator
MGST3 microsomal glutathione S-transferase 3
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NOSIP nitric oxide synthase interacting protein
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDZRN3 PDZ domain containing ring finger 3
PEG10 paternally expressed 10
PLA2G15 phospholipase A2, group XV
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SCPEP1 serine carboxypeptidase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRGN serglycin
TFF3 trefoil factor 3 (intestinal)
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TIMP3 TIMP metallopeptidase inhibitor 3
TKTL1 transketolase-like 1
TPST2 tyrosylprotein sulfotransferase 2
TRAM2 translocation associated membrane protein 2
TSPAN7 tetraspanin 7
XYLT1 xylosyltransferase I
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ALCAM activated leukocyte cell adhesion molecule
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA1 annexin A1
ANXA3 annexin A3
ANXA4 annexin A4
ATF5 activating transcription factor 5
BAZ1A bromodomain adjacent to zinc finger domain, 1A
C6ORF62 chromosome 6 open reading frame 62
CCNA2 cyclin A2
CCND1 cyclin D1
CCNG1 cyclin G1
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CIRBP cold inducible RNA binding protein
COCH cochlin
COL4A6 collagen, type IV, alpha 6
CTBP1 C-terminal binding protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
DCK deoxycytidine kinase
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DRAM1 DNA-damage regulated autophagy modulator 1
DUT deoxyuridine triphosphatase
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FAS Fas cell surface death receptor
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GOLGA8A golgin A8 family, member A
GOLGA8H golgin A8 family, member H
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXB6 homeobox B6
IFITM3 interferon induced transmembrane protein 3
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KEAP1 kelch-like ECH-associated protein 1
KIAA0101 KIAA0101
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KPNB1 karyopherin (importin) beta 1
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MET MET proto-oncogene, receptor tyrosine kinase
MFAP5 microfibrillar associated protein 5
MRPL19 mitochondrial ribosomal protein L19
MSLN mesothelin
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NMI N-myc (and STAT) interactor
NUP50 nucleoporin 50kDa
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PAX8 paired box 8
PDGFA platelet-derived growth factor alpha polypeptide
PDGFC platelet derived growth factor C
PDIA3 protein disulfide isomerase family A, member 3
PLAGL1 pleiomorphic adenoma gene-like 1
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGIS prostaglandin I2 (prostacyclin) synthase
RBM47 RNA binding motif protein 47
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RDX radixin
RGS5 regulator of G-protein signaling 5
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SFN stratifin
SLC35F2 solute carrier family 35, member F2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SORBS3 sorbin and SH3 domain containing 3
SPATA20 spermatogenesis associated 20
STEAP3 STEAP family member 3, metalloreductase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TIMP1 TIMP metallopeptidase inhibitor 1
TLK1 tousled-like kinase 1
TM4SF1 transmembrane 4 L six family member 1
TMEM5 transmembrane protein 5
TNIP1 TNFAIP3 interacting protein 1
TRIM22 tripartite motif containing 22
TUBB6 tubulin, beta 6 class V
TYMS thymidylate synthetase
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZHX2 zinc fingers and homeoboxes 2
ZNF652 zinc finger protein 652
Funding