BRD-K69840642_HDAC6 inhibitor ISOX_SW620_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

163 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_SW620_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ALAS1 5'-aminolevulinate synthase 1
ASMTL acetylserotonin O-methyltransferase-like
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIK BCL2-interacting killer (apoptosis-inducing)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
CALD1 caldesmon 1
CALR calreticulin
CALU calumenin
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CD22 CD22 molecule
CD9 CD9 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CIB1 calcium and integrin binding 1 (calmyrin)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC4 chloride intracellular channel 4
COL11A1 collagen, type XI, alpha 1
DGKA diacylglycerol kinase, alpha 80kDa
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EZR ezrin
FADS3 fatty acid desaturase 3
FAM117A family with sequence similarity 117, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FN1 fibronectin 1
FOXO4 forkhead box O4
GAS1 growth arrest-specific 1
GLRX glutaredoxin (thioltransferase)
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GSDMB gasdermin B
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
IQGAP1 IQ motif containing GTPase activating protein 1
IQGAP2 IQ motif containing GTPase activating protein 2
ITM2C integral membrane protein 2C
JUN jun proto-oncogene
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LBH limb bud and heart development
LITAF lipopolysaccharide-induced TNF factor
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MGST3 microsomal glutathione S-transferase 3
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MT1X metallothionein 1X
MVP major vault protein
NR4A2 nuclear receptor subfamily 4, group A, member 2
NVL nuclear VCP-like
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G15 phospholipase A2, group XV
PLAU plasminogen activator, urokinase
PRKCD protein kinase C, delta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SELENBP1 selenium binding protein 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SNN stannin
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STK17A serine/threonine kinase 17a
TFF3 trefoil factor 3 (intestinal)
TLE4 transducin-like enhancer of split 4
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VNN1 vanin 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ATF1 activating transcription factor 1
BEX1 brain expressed, X-linked 1
CA12 carbonic anhydrase XII
CD93 CD93 molecule
CTPS1 CTP synthase 1
DACH1 dachshund family transcription factor 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUT deoxyuridine triphosphatase
EBAG9 estrogen receptor binding site associated, antigen, 9
EXOSC8 exosome component 8
FAM216A family with sequence similarity 216, member A
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
GAS2 growth arrest-specific 2
GATAD1 GATA zinc finger domain containing 1
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GPX2 glutathione peroxidase 2
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGA2 high mobility group AT-hook 2
HMGN3 high mobility group nucleosomal binding domain 3
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPB8 heat shock 22kDa protein 8
IRAK1 interleukin-1 receptor-associated kinase 1
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
MRPL15 mitochondrial ribosomal protein L15
MTA1 metastasis associated 1
MYH11 myosin, heavy chain 11, smooth muscle
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
MYO5C myosin VC
NBN nibrin
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
PDGFA platelet-derived growth factor alpha polypeptide
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PKP4 plakophilin 4
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
PLN phospholamban
PRMT1 protein arginine methyltransferase 1
PUS7 pseudouridylate synthase 7 (putative)
RAD23B RAD23 homolog B (S. cerevisiae)
RCAN2 regulator of calcineurin 2
RCC1 regulator of chromosome condensation 1
RELN reelin
REPIN1 replication initiator 1
RGS5 regulator of G-protein signaling 5
RTN1 reticulon 1
SENP6 SUMO1/sentrin specific peptidase 6
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SLC35F2 solute carrier family 35, member F2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMAGP small cell adhesion glycoprotein
SMYD2 SET and MYND domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TARBP1 TAR (HIV-1) RNA binding protein 1
TCERG1 transcription elongation regulator 1
TF transferrin
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TM9SF3 transmembrane 9 superfamily member 3
USP22 ubiquitin specific peptidase 22
Funding