BRD-K69840642_HDAC6 inhibitor ISOX_U937_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

265 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_U937_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACAA1 acetyl-CoA acyltransferase 1
ACO1 aconitase 1, soluble
ADAM28 ADAM metallopeptidase domain 28
ADD3 adducin 3 (gamma)
AHCYL2 adenosylhomocysteinase-like 2
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C3 aldo-keto reductase family 1, member C3
ALAS1 5'-aminolevulinate synthase 1
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARMCX2 armadillo repeat containing, X-linked 2
ASMTL acetylserotonin O-methyltransferase-like
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BLVRB biliverdin reductase B
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C1ORF115 chromosome 1 open reading frame 115
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCDC28A coiled-coil domain containing 28A
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CGRRF1 cell growth regulator with ring finger domain 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN10 claudin 10
CPB1 carboxypeptidase B1 (tissue)
CPD carboxypeptidase D
CPNE3 copine III
CREG1 cellular repressor of E1A-stimulated genes 1
CTR9 CTR9, Paf1/RNA polymerase II complex component
CYB5R1 cytochrome b5 reductase 1
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUSP10 dual specificity phosphatase 10
DYNLT1 dynein, light chain, Tctex-type 1
ECI2 enoyl-CoA delta isomerase 2
EDN3 endothelin 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM117A family with sequence similarity 117, member A
FCGBP Fc fragment of IgG binding protein
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FUCA1 fucosidase, alpha-L- 1, tissue
G6PD glucose-6-phosphate dehydrogenase
GALC galactosylceramidase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLRX glutaredoxin (thioltransferase)
GOLGA7 golgin A7
GPX3 glutathione peroxidase 3
GRN granulin
H1F0 H1 histone family, member 0
HEBP1 heme binding protein 1
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HIST1H3H histone cluster 1, H3h
HLTF helicase-like transcription factor
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HPCAL1 hippocalcin-like 1
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IER5 immediate early response 5
IFT57 intraflagellar transport 57
IQCG IQ motif containing G
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
LGALS1 lectin, galactoside-binding, soluble, 1
LPIN1 lipin 1
LTA4H leukotriene A4 hydrolase
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCOLN1 mucolipin 1
MGLL monoglyceride lipase
MGST3 microsomal glutathione S-transferase 3
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MKNK1 MAP kinase interacting serine/threonine kinase 1
MLF1 myeloid leukemia factor 1
MPZL1 myelin protein zero-like 1
MSMO1 methylsterol monooxygenase 1
MVP major vault protein
MXRA7 matrix-remodelling associated 7
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NIT1 nitrilase 1
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
OSBPL3 oxysterol binding protein-like 3
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G15 phospholipase A2, group XV
PLIN2 perilipin 2
PLS1 plastin 1
POLB polymerase (DNA directed), beta
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POPDC3 popeye domain containing 3
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS3 protease, serine, 3
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBKS ribokinase
RBP1 retinol binding protein 1, cellular
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAGA Ras-related GTP binding A
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SF3B5 splicing factor 3b, subunit 5, 10kDa
SGK1 serum/glucocorticoid regulated kinase 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC46A3 solute carrier family 46, member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX9 SRY (sex determining region Y)-box 9
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STC1 stanniocalcin 1
STXBP1 syntaxin binding protein 1
TBPL1 TBP-like 1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TKTL1 transketolase-like 1
TMEM41B transmembrane protein 41B
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNNT1 troponin T type 1 (skeletal, slow)
TOB1 transducer of ERBB2, 1
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TSPYL5 TSPY-like 5
TUBB2A tubulin, beta 2A class IIa
VAMP3 vesicle-associated membrane protein 3
VASH2 vasohibin 2
VCL vinculin
VWA5A von Willebrand factor A domain containing 5A
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ADI1 acireductone dioxygenase 1
AKAP8 A kinase (PRKA) anchor protein 8
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMOTL2 angiomotin like 2
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
APOD apolipoprotein D
ATF5 activating transcription factor 5
AZU1 azurocidin 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BEX1 brain expressed, X-linked 1
C1QBP complement component 1, q subcomponent binding protein
C2CD2 C2 calcium-dependent domain containing 2
C6ORF62 chromosome 6 open reading frame 62
CCL2 chemokine (C-C motif) ligand 2
CD200 CD200 molecule
CD24 CD24 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CES1 carboxylesterase 1
COCH cochlin
CST7 cystatin F (leukocystatin)
CTPS1 CTP synthase 1
CYC1 cytochrome c-1
DENND2D DENN/MADD domain containing 2D
DKC1 dyskeratosis congenita 1, dyskerin
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5A eukaryotic translation initiation factor 5A
ELANE elastase, neutrophil expressed
ELF1 E74-like factor 1 (ets domain transcription factor)
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EVL Enah/Vasp-like
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FXYD5 FXYD domain containing ion transport regulator 5
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GRB14 growth factor receptor-bound protein 14
GRWD1 glutamate-rich WD repeat containing 1
GSAP gamma-secretase activating protein
GSTO1 glutathione S-transferase omega 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HAPLN1 hyaluronan and proteoglycan link protein 1
HDGF hepatoma-derived growth factor
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXA10 homeobox A10
IGHM immunoglobulin heavy constant mu
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
LPL lipoprotein lipase
LY6E lymphocyte antigen 6 complex, locus E
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MARCKS myristoylated alanine-rich protein kinase C substrate
MBP myelin basic protein
MRPS2 mitochondrial ribosomal protein S2
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NID1 nidogen 1
NMI N-myc (and STAT) interactor
NOP16 NOP16 nucleolar protein
NR2F6 nuclear receptor subfamily 2, group F, member 6
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
PGAM1 phosphoglycerate mutase 1 (brain)
PIEZO2 piezo-type mechanosensitive ion channel component 2
PKP4 plakophilin 4
PLK1 polo-like kinase 1
PODXL podocalyxin-like
PRTN3 proteinase 3
PUF60 poly-U binding splicing factor 60KDa
RCN1 reticulocalbin 1, EF-hand calcium binding domain
REPIN1 replication initiator 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A1 S100 calcium binding protein A1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC2 syndecan 2
SET SET nuclear proto-oncogene
SPRY2 sprouty homolog 2 (Drosophila)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TF transferrin
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TMEM87A transmembrane protein 87A
TNS3 tensin 3
TUBB6 tubulin, beta 6 class V
TYMS thymidylate synthetase
USP22 ubiquitin specific peptidase 22
XBP1 X-box binding protein 1
ZBTB1 zinc finger and BTB domain containing 1
ZMYND8 zinc finger, MYND-type containing 8
Funding