BRD-K69840642_HDAC6 inhibitor ISOX_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

278 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADAMDEC1 ADAM-like, decysin 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AHNAK AHNAK nucleoprotein
AIM2 absent in melanoma 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
BTG2 BTG family, member 2
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCDC28A coiled-coil domain containing 28A
CCL5 chemokine (C-C motif) ligand 5
CCNG2 cyclin G2
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CD8A CD8a molecule
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLCA4 chloride channel accessory 4
CLMN calmin (calponin-like, transmembrane)
CRABP2 cellular retinoic acid binding protein 2
CRIP2 cysteine-rich protein 2
CST6 cystatin E/M
CTSA cathepsin A
CYB5R1 cytochrome b5 reductase 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DMD dystrophin
EAF2 ELL associated factor 2
EFHD1 EF-hand domain family, member D1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EZR ezrin
FADS3 fatty acid desaturase 3
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXO4 forkhead box O4
G6PD glucose-6-phosphate dehydrogenase
GABARAPL2 GABA(A) receptor-associated protein-like 2
GAS7 growth arrest-specific 7
GDE1 glycerophosphodiester phosphodiesterase 1
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GRN granulin
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
LPXN leupaxin
MAGEB2 melanoma antigen family B2
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MBNL2 muscleblind-like splicing regulator 2
MBP myelin basic protein
MCOLN1 mucolipin 1
MEGF9 multiple EGF-like-domains 9
METRN meteorin, glial cell differentiation regulator
NDNF neuron-derived neurotrophic factor
NDRG2 NDRG family member 2
NEBL nebulette
NMT2 N-myristoyltransferase 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRCAM neuronal cell adhesion molecule
OPTN optineurin
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLP1 proteolipid protein 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRKCD protein kinase C, delta
RAD9A RAD9 homolog A (S. pombe)
RGS13 regulator of G-protein signaling 13
RHOBTB3 Rho-related BTB domain containing 3
RNF167 ring finger protein 167
RTN3 reticulon 3
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SH3BGRL SH3 domain binding glutamate-rich protein like
SKAP2 src kinase associated phosphoprotein 2
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNN stannin
SORBS1 sorbin and SH3 domain containing 1
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SST somatostatin
STMN2 stathmin 2
STOM stomatin
STX1A syntaxin 1A (brain)
TAC1 tachykinin, precursor 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TKTL1 transketolase-like 1
TPP1 tripeptidyl peptidase I
TWF2 twinfilin actin binding protein 2
TXNRD1 thioredoxin reductase 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VWA5A von Willebrand factor A domain containing 5A
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF423 zinc finger protein 423
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADCY1 adenylate cyclase 1 (brain)
ADGRE5 adhesion G protein-coupled receptor E5
ADI1 acireductone dioxygenase 1
AHCY adenosylhomocysteinase
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
AQP3 aquaporin 3 (Gill blood group)
ARMCX2 armadillo repeat containing, X-linked 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF5 activating transcription factor 5
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKA aurora kinase A
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CBR3 carbonyl reductase 3
CBS cystathionine-beta-synthase
CCNA2 cyclin A2
CDC25B cell division cycle 25B
CENPE centromere protein E, 312kDa
CEP55 centrosomal protein 55kDa
CKAP4 cytoskeleton-associated protein 4
CMC4 C-x(9)-C motif containing 4
COCH cochlin
COMT catechol-O-methyltransferase
CRTAP cartilage associated protein
CTPS1 CTP synthase 1
CTSO cathepsin O
DCTD dCMP deaminase
DCXR dicarbonyl/L-xylulose reductase
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DUT deoxyuridine triphosphatase
ECT2 epithelial cell transforming 2
EXOSC8 exosome component 8
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FAS Fas cell surface death receptor
FOXM1 forkhead box M1
FXN frataxin
FXYD3 FXYD domain containing ion transport regulator 3
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GCFC2 GC-rich sequence DNA-binding factor 2
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GREB1 growth regulation by estrogen in breast cancer 1
GTF3A general transcription factor IIIA
GTPBP8 GTP-binding protein 8 (putative)
GTSE1 G-2 and S-phase expressed 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HPN hepsin
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IARS isoleucyl-tRNA synthetase
ICA1 islet cell autoantigen 1, 69kDa
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ING3 inhibitor of growth family, member 3
IRAK1 interleukin-1 receptor-associated kinase 1
KEAP1 kelch-like ECH-associated protein 1
KIAA0020 KIAA0020
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KLK11 kallikrein-related peptidase 11
KRT23 keratin 23, type I
LMNB1 lamin B1
LY6E lymphocyte antigen 6 complex, locus E
LYPLA1 lysophospholipase I
MARC1 mitochondrial amidoxime reducing component 1
MINA MYC induced nuclear antigen
MRPL12 mitochondrial ribosomal protein L12
MRPS30 mitochondrial ribosomal protein S30
MSLN mesothelin
MSMB microseminoprotein, beta-
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NFIB nuclear factor I/B
NIT2 nitrilase family, member 2
NKX3-1 NK3 homeobox 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOP16 NOP16 nucleolar protein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OBSL1 obscurin-like 1
ODC1 ornithine decarboxylase 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAK1IP1 PAK1 interacting protein 1
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PDGFA platelet-derived growth factor alpha polypeptide
PDGFC platelet derived growth factor C
PGLS 6-phosphogluconolactonase
PHGDH phosphoglycerate dehydrogenase
PLCB4 phospholipase C, beta 4
PLK1 polo-like kinase 1
PRDX4 peroxiredoxin 4
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGIS prostaglandin I2 (prostacyclin) synthase
PTX3 pentraxin 3, long
PUS7 pseudouridylate synthase 7 (putative)
PYCR1 pyrroline-5-carboxylate reductase 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL37A ribosomal protein L37a
S100P S100 calcium binding protein P
SCGB2A1 secretoglobin, family 2A, member 1
SEH1L SEH1-like (S. cerevisiae)
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SORBS2 sorbin and SH3 domain containing 2
SPDEF SAM pointed domain containing ETS transcription factor
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRSF7 serine/arginine-rich splicing factor 7
SSR4 signal sequence receptor, delta
ST7 suppression of tumorigenicity 7
STC2 stanniocalcin 2
STEAP3 STEAP family member 3, metalloreductase
STK26 serine/threonine protein kinase 26
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SUMO3 small ubiquitin-like modifier 3
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMED3 transmembrane emp24 protein transport domain containing 3
TMEM5 transmembrane protein 5
TMF1 TATA element modulatory factor 1
TMPO thymopoietin
TMX4 thioredoxin-related transmembrane protein 4
TNPO1 transportin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TRIM29 tripartite motif containing 29
TRIP13 thyroid hormone receptor interactor 13
TSPAN8 tetraspanin 8
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UCK2 uridine-cytidine kinase 2
URI1 URI1, prefoldin-like chaperone
VBP1 von Hippel-Lindau binding protein 1
WDR43 WD repeat domain 43
XPO1 exportin 1
XPOT exportin, tRNA
Funding