BRD-K69932463_AZD-8055_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-K69932463_AZD-8055_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARID5B AT rich interactive domain 5B (MRF1-like)
ATP9A ATPase, class II, type 9A
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CPT1A carnitine palmitoyltransferase 1A (liver)
DCN decorin
DKK3 dickkopf WNT signaling pathway inhibitor 3
EDN1 endothelin 1
EDN3 endothelin 3
EIF3G eukaryotic translation initiation factor 3, subunit G
EIF5A eukaryotic translation initiation factor 5A
FAR2 fatty acyl CoA reductase 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GOLGA8H golgin A8 family, member H
GSDMB gasdermin B
HTRA1 HtrA serine peptidase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KCTD12 potassium channel tetramerization domain containing 12
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
LCN2 lipocalin 2
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MECOM MDS1 and EVI1 complex locus
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
MMP7 matrix metallopeptidase 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOTCH1 notch 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PROM1 prominin 1
PTCH1 patched 1
PTPRO protein tyrosine phosphatase, receptor type, O
RAP1GAP2 RAP1 GTPase activating protein 2
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
STK10 serine/threonine kinase 10
SULF1 sulfatase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNE2 spectrin repeat containing, nuclear envelope 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TLE4 transducin-like enhancer of split 4
TPPP3 tubulin polymerization-promoting protein family member 3
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
VNN1 vanin 1
WDR13 WD repeat domain 13
XYLT1 xylosyltransferase I
ZEB1 zinc finger E-box binding homeobox 1

decreased expression

Symbol Name
ADGRG1 adhesion G protein-coupled receptor G1
ADI1 acireductone dioxygenase 1
AFP alpha-fetoprotein
AHSG alpha-2-HS-glycoprotein
AK4 adenylate kinase 4
ALB albumin
ALDOC aldolase C, fructose-bisphosphate
APOA2 apolipoprotein A-II
APOB apolipoprotein B
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
BAG2 BCL2-associated athanogene 2
BAG3 BCL2-associated athanogene 3
BCHE butyrylcholinesterase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BST2 bone marrow stromal cell antigen 2
CBS cystathionine-beta-synthase
CCL2 chemokine (C-C motif) ligand 2
CD58 CD58 molecule
CFD complement factor D (adipsin)
CHI3L2 chitinase 3-like 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
CPVL carboxypeptidase, vitellogenic-like
CTSC cathepsin C
CTSH cathepsin H
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
ENO2 enolase 2 (gamma, neuronal)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM162A family with sequence similarity 162, member A
FASTKD3 FAST kinase domains 3
FGFR4 fibroblast growth factor receptor 4
FKBP14 FK506 binding protein 14, 22 kDa
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GARS glycyl-tRNA synthetase
GCLM glutamate-cysteine ligase, modifier subunit
HEXIM1 hexamethylene bis-acetamide inducible 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP1 insulin-like growth factor binding protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
LAPTM4B lysosomal protein transmembrane 4 beta
LDLR low density lipoprotein receptor
LMO4 LIM domain only 4
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
MT1X metallothionein 1X
NEU1 sialidase 1 (lysosomal sialidase)
NKX3-1 NK3 homeobox 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PDIA6 protein disulfide isomerase family A, member 6
PFN2 profilin 2
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PKM pyruvate kinase, muscle
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSAT1 phosphoserine aminotransferase 1
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMYD3 SET and MYND domain containing 3
SORD sorbitol dehydrogenase
SRPRB signal recognition particle receptor, B subunit
SSR1 signal sequence receptor, alpha
TARS threonyl-tRNA synthetase
TFRC transferrin receptor
TMEM14A transmembrane protein 14A
TNC tenascin C
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
YARS tyrosyl-tRNA synthetase
Funding