BRD-K69932463_AZD-8055_MCF10A_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

222 genes differentially expressed following the BRD-K69932463_AZD-8055_MCF10A_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
APOD apolipoprotein D
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
BCAS3 breast carcinoma amplified sequence 3
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CAPN1 calpain 1, (mu/I) large subunit
CCNG2 cyclin G2
CFB complement factor B
CFD complement factor D (adipsin)
CP ceruloplasmin (ferroxidase)
CSTA cystatin A (stefin A)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
FADS3 fatty acid desaturase 3
FAXDC2 fatty acid hydroxylase domain containing 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
GPATCH8 G patch domain containing 8
GPC4 glypican 4
GRN granulin
GSN gelsolin
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IRS1 insulin receptor substrate 1
ITGAV integrin, alpha V
ITGB4 integrin, beta 4
KDM5B lysine (K)-specific demethylase 5B
KYNU kynureninase
L1CAM L1 cell adhesion molecule
LAMA3 laminin, alpha 3
LAMC2 laminin, gamma 2
LDOC1 leucine zipper, down-regulated in cancer 1
LEPROT leptin receptor overlapping transcript
LGALS3 lectin, galactoside-binding, soluble, 3
LOXL2 lysyl oxidase-like 2
LTBP1 latent transforming growth factor beta binding protein 1
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MMD monocyte to macrophage differentiation-associated
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MYL9 myosin, light chain 9, regulatory
NRIP1 nuclear receptor interacting protein 1
NT5E 5'-nucleotidase, ecto (CD73)
OPN3 opsin 3
OPTN optineurin
OSMR oncostatin M receptor
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDGFD platelet derived growth factor D
PLA2G16 phospholipase A2, group XVI
PLXNB2 plexin B2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPL periplakin
PRSS21 protease, serine, 21 (testisin)
PSAP prosaposin
PTGES prostaglandin E synthase
PTK2B protein tyrosine kinase 2 beta
RBP4 retinol binding protein 4, plasma
RRAS related RAS viral (r-ras) oncogene homolog
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SOX4 SRY (sex determining region Y)-box 4
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TIMP2 TIMP metallopeptidase inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNIP1 TNFAIP3 interacting protein 1
TPM2 tropomyosin 2 (beta)
TSC22D3 TSC22 domain family, member 3
TSPAN31 tetraspanin 31
VAT1 vesicle amine transport 1
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADI1 acireductone dioxygenase 1
AMD1 adenosylmethionine decarboxylase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AQP3 aquaporin 3 (Gill blood group)
ARPC5L actin related protein 2/3 complex, subunit 5-like
ASF1A anti-silencing function 1A histone chaperone
AURKA aurora kinase A
AURKB aurora kinase B
BCHE butyrylcholinesterase
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNC cyclin C
CCND2 cyclin D2
CD320 CD320 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL14 chemokine (C-X-C motif) ligand 14
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECI2 enoyl-CoA delta isomerase 2
FAM129A family with sequence similarity 129, member A
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FKBP11 FK506 binding protein 11, 19 kDa
FOXM1 forkhead box M1
FRZB frizzled-related protein
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
GYG1 glycogenin 1
HACD3 3-hydroxyacyl-CoA dehydratase 3
HAT1 histone acetyltransferase 1
HIST1H4C histone cluster 1, H4c
HMGB2 high mobility group box 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA4L heat shock 70kDa protein 4-like
HSPB8 heat shock 22kDa protein 8
IL13RA2 interleukin 13 receptor, alpha 2
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
JMJD6 jumonji domain containing 6
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LBR lamin B receptor
LEF1 lymphoid enhancer-binding factor 1
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MALL mal, T-cell differentiation protein-like
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MLEC malectin
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NEK2 NIMA-related kinase 2
NOP56 NOP56 ribonucleoprotein
NUSAP1 nucleolar and spindle associated protein 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PSRC1 proline/serine-rich coiled-coil 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RGS2 regulator of G-protein signaling 2
RPA2 replication protein A2, 32kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SERP1 stress-associated endoplasmic reticulum protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SNRPG small nuclear ribonucleoprotein polypeptide G
SORD sorbitol dehydrogenase
SPP1 secreted phosphoprotein 1
SRSF3 serine/arginine-rich splicing factor 3
SUB1 SUB1 homolog (S. cerevisiae)
TACC3 transforming, acidic coiled-coil containing protein 3
TDO2 tryptophan 2,3-dioxygenase
TFF3 trefoil factor 3 (intestinal)
TIPIN TIMELESS interacting protein
TMEM70 transmembrane protein 70
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52 tumor protein D52
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TWF1 twinfilin actin binding protein 1
UBE2S ubiquitin-conjugating enzyme E2S
VDAC3 voltage-dependent anion channel 3
VRK1 vaccinia related kinase 1
WBSCR22 Williams Beuren syndrome chromosome region 22
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein
Funding