BRD-K70161581_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-K70161581_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AHNAK2 AHNAK nucleoprotein 2
AK4 adenylate kinase 4
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPTL4 angiopoietin-like 4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA9 carbonic anhydrase IX
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
DARS aspartyl-tRNA synthetase
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DLX2 distal-less homeobox 2
DUSP1 dual specificity phosphatase 1
EGFR epidermal growth factor receptor
ELF4 E74-like factor 4 (ets domain transcription factor)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO2 enolase 2 (gamma, neuronal)
EPHA2 EPH receptor A2
ERO1L ERO1-like (S. cerevisiae)
FAM162A family with sequence similarity 162, member A
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GBE1 glucan (1,4-alpha-), branching enzyme 1
GCLC glutamate-cysteine ligase, catalytic subunit
GJA1 gap junction protein, alpha 1, 43kDa
GPI glucose-6-phosphate isomerase
GPR87 G protein-coupled receptor 87
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX2 glutathione peroxidase 2
GSN gelsolin
HK2 hexokinase 2
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMOX1 heme oxygenase 1
IGFBP3 insulin-like growth factor binding protein 3
INHBA inhibin, beta A
JAG1 jagged 1
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KRT13 keratin 13, type I
KRT6A keratin 6A, type II
LDHB lactate dehydrogenase B
LOXL2 lysyl oxidase-like 2
MMP12 matrix metallopeptidase 12
MT1X metallothionein 1X
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NOTCH1 notch 1
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A4 S100 calcium binding protein A4
S100P S100 calcium binding protein P
SCARB1 scavenger receptor class B, member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFN stratifin
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
STC1 stanniocalcin 1
SULF1 sulfatase 1
TACC1 transforming, acidic coiled-coil containing protein 1
TGFA transforming growth factor, alpha
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRIM2 tripartite motif containing 2
VEGFA vascular endothelial growth factor A
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
BIRC5 baculoviral IAP repeat containing 5
C20ORF27 chromosome 20 open reading frame 27
CDC20 cell division cycle 20
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
CXCL12 chemokine (C-X-C motif) ligand 12
DBF4 DBF4 zinc finger
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EIF5A eukaryotic translation initiation factor 5A
EVL Enah/Vasp-like
FAM35A family with sequence similarity 35, member A
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA3 GATA binding protein 3
GRWD1 glutamate-rich WD repeat containing 1
HMG20B high mobility group 20B
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
IGFBP4 insulin-like growth factor binding protein 4
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IRX5 iroquois homeobox 5
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LMO2 LIM domain only 2 (rhombotin-like 1)
MRPL12 mitochondrial ribosomal protein L12
MRPL3 mitochondrial ribosomal protein L3
MRPS30 mitochondrial ribosomal protein S30
NFIB nuclear factor I/B
NR2F2 nuclear receptor subfamily 2, group F, member 2
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PBK PDZ binding kinase
PCCB propionyl CoA carboxylase, beta polypeptide
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PROM1 prominin 1
PSIP1 PC4 and SFRS1 interacting protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RPA3 replication protein A3, 14kDa
RPS11 ribosomal protein S11
SIX1 SIX homeobox 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPDEF SAM pointed domain containing ETS transcription factor
SRSF1 serine/arginine-rich splicing factor 1
STRA13 stimulated by retinoic acid 13
TMPO thymopoietin
TSPAN13 tetraspanin 13
UBE2S ubiquitin-conjugating enzyme E2S
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
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