BRD-K70401845_erlotinib_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-K70401845_erlotinib_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA4 annexin A4
APOD apolipoprotein D
ATP9A ATPase, class II, type 9A
C1QB complement component 1, q subcomponent, B chain
CAPN1 calpain 1, (mu/I) large subunit
CD14 CD14 molecule
CD163 CD163 molecule
CD59 CD59 molecule, complement regulatory protein
CFB complement factor B
CRYAB crystallin, alpha B
CTSB cathepsin B
CTSH cathepsin H
CYB5A cytochrome b5 type A (microsomal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FPGS folylpolyglutamate synthase
FRMD4B FERM domain containing 4B
GLUL glutamate-ammonia ligase
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
HSPB8 heat shock 22kDa protein 8
KRT23 keratin 23, type I
KRT7 keratin 7, type II
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LTBP3 latent transforming growth factor beta binding protein 3
MAPT microtubule-associated protein tau
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
MT1F metallothionein 1F
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MYL9 myosin, light chain 9, regulatory
NEBL nebulette
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NUPR1 nuclear protein, transcriptional regulator, 1
PAM peptidylglycine alpha-amidating monooxygenase
PCP4 Purkinje cell protein 4
PDZK1 PDZ domain containing 1
PDZK1IP1 PDZK1 interacting protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
PROM1 prominin 1
QPRT quinolinate phosphoribosyltransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBP1 retinol binding protein 1, cellular
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGD Ras-related GTP binding D
SC5D sterol-C5-desaturase
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SPON2 spondin 2, extracellular matrix protein
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTA T-cell leukemia translocation altered
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNS1 tensin 1
TPD52L1 tumor protein D52-like 1
TSC22D3 TSC22 domain family, member 3
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARL4C ADP-ribosylation factor-like 4C
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CLEC2B C-type lectin domain family 2, member B
COL1A2 collagen, type I, alpha 2
DEGS1 delta(4)-desaturase, sphingolipid 1
DLK1 delta-like 1 homolog (Drosophila)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ETV5 ets variant 5
FGFR3 fibroblast growth factor receptor 3
FKBP14 FK506 binding protein 14, 22 kDa
FOXF2 forkhead box F2
GAL galanin/GMAP prepropeptide
HELLS helicase, lymphoid-specific
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
MCM10 minichromosome maintenance complex component 10
NEK2 NIMA-related kinase 2
PBK PDZ binding kinase
POSTN periostin, osteoblast specific factor
PSD3 pleckstrin and Sec7 domain containing 3
PSPH phosphoserine phosphatase
RAD51AP1 RAD51 associated protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
SHCBP1 SHC SH2-domain binding protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPRY2 sprouty homolog 2 (Drosophila)
TIAM1 T-cell lymphoma invasion and metastasis 1
VIM vimentin
ZEB1 zinc finger E-box binding homeobox 1
ZWINT ZW10 interacting kinetochore protein
Funding