BRD-K70511574_sunitinib_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K70511574_sunitinib_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
AEBP1 AE binding protein 1
ARHGAP29 Rho GTPase activating protein 29
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLGN calmegin
CNN3 calponin 3, acidic
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DUSP14 dual specificity phosphatase 14
EGR1 early growth response 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EMP1 epithelial membrane protein 1
FAS Fas cell surface death receptor
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAL galanin/GMAP prepropeptide
GAS6 growth arrest-specific 6
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSPA4L heat shock 70kDa protein 4-like
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
KIAA0226L KIAA0226-like
LAMC2 laminin, gamma 2
LGALS3 lectin, galactoside-binding, soluble, 3
MAOB monoamine oxidase B
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MT1E metallothionein 1E
PDLIM5 PDZ and LIM domain 5
PIP prolactin-induced protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTRF polymerase I and transcript release factor
RGS2 regulator of G-protein signaling 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERTAD2 SERTA domain containing 2
SESN1 sestrin 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SNAI2 snail family zinc finger 2
SOCS2 suppressor of cytokine signaling 2
TCF4 transcription factor 4
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR3 transforming growth factor, beta receptor III
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TRIP6 thyroid hormone receptor interactor 6
UGCG UDP-glucose ceramide glucosyltransferase
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZMAT3 zinc finger, matrin-type 3
ZNF652 zinc finger protein 652
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C9ORF16 chromosome 9 open reading frame 16
CCL5 chemokine (C-C motif) ligand 5
CDK1 cyclin-dependent kinase 1
COL5A2 collagen, type V, alpha 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB3 erb-b2 receptor tyrosine kinase 3
G6PD glucose-6-phosphate dehydrogenase
GLRX glutaredoxin (thioltransferase)
GNAS GNAS complex locus
HMGA2 high mobility group AT-hook 2
HSPA1A heat shock 70kDa protein 1A
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LAMB1 laminin, beta 1
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NISCH nischarin
NQO1 NAD(P)H dehydrogenase, quinone 1
NRP1 neuropilin 1
PAM peptidylglycine alpha-amidating monooxygenase
PGD phosphogluconate dehydrogenase
PGM1 phosphoglucomutase 1
PLTP phospholipid transfer protein
RAB13 RAB13, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100A7 S100 calcium binding protein A7
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPTSSA serine palmitoyltransferase, small subunit A
STXBP2 syntaxin binding protein 2
SYNGR1 synaptogyrin 1
TNNT1 troponin T type 1 (skeletal, slow)
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBA1A tubulin, alpha 1a
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A
WWTR1 WW domain containing transcription regulator 1
ZMYND8 zinc finger, MYND-type containing 8
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