BRD-K70511574_sunitinib_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-K70511574_sunitinib_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
AURKA aurora kinase A
BAG2 BCL2-associated athanogene 2
CHIC2 cysteine-rich hydrophobic domain 2
COBL cordon-bleu WH2 repeat protein
CRYAB crystallin, alpha B
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DAPK1 death-associated protein kinase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
FAM46A family with sequence similarity 46, member A
FOLR1 folate receptor 1 (adult)
GAS6 growth arrest-specific 6
GPM6B glycoprotein M6B
HACD1 3-hydroxyacyl-CoA dehydratase 1
HDGFRP3 hepatoma-derived growth factor, related protein 3
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HOMER1 homer scaffolding protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL6ST interleukin 6 signal transducer
IRS2 insulin receptor substrate 2
KCTD5 potassium channel tetramerization domain containing 5
LAPTM4B lysosomal protein transmembrane 4 beta
MAGEA6 melanoma antigen family A6
MFAP3L microfibrillar-associated protein 3-like
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MT1H metallothionein 1H
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NNMT nicotinamide N-methyltransferase
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTS neurotensin
NUP98 nucleoporin 98kDa
P3H2 prolyl 3-hydroxylase 2
PAWR PRKC, apoptosis, WT1, regulator
PDLIM5 PDZ and LIM domain 5
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
POSTN periostin, osteoblast specific factor
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
QKI QKI, KH domain containing, RNA binding
RAB15 RAB15, member RAS oncogene family
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFTN1 raftlin, lipid raft linker 1
RPS26 ribosomal protein S26
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SOCS2 suppressor of cytokine signaling 2
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TBL1X transducin (beta)-like 1X-linked
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TYRP1 tyrosinase-related protein 1
UBE2S ubiquitin-conjugating enzyme E2S

decreased expression

Symbol Name
ADM adrenomedullin
AIM1 absent in melanoma 1
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDOB aldolase B, fructose-bisphosphate
ANKRD36B ankyrin repeat domain 36B
ANXA1 annexin A1
ASPH aspartate beta-hydroxylase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNE2 cyclin E2
CD164 CD164 molecule, sialomucin
CD58 CD58 molecule
CD9 CD9 molecule
CDK1 cyclin-dependent kinase 1
CFB complement factor B
COL3A1 collagen, type III, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CREB1 cAMP responsive element binding protein 1
CRIP1 cysteine-rich protein 1 (intestinal)
CSTA cystatin A (stefin A)
CXCL14 chemokine (C-X-C motif) ligand 14
DHRS9 dehydrogenase/reductase (SDR family) member 9
DPP4 dipeptidyl-peptidase 4
DPT dermatopontin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ETV1 ets variant 1
FAM129A family with sequence similarity 129, member A
FGFR1 fibroblast growth factor receptor 1
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GCLC glutamate-cysteine ligase, catalytic subunit
GOLGA8B golgin A8 family, member B
GOLT1B golgi transport 1B
GSTT1 glutathione S-transferase theta 1
HIST1H4C histone cluster 1, H4c
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KRT13 keratin 13, type I
KRT15 keratin 15, type I
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS4 lectin, galactoside-binding, soluble, 4
LINC00342 long intergenic non-protein coding RNA 342
MAPT microtubule-associated protein tau
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MFAP2 microfibrillar-associated protein 2
MOXD1 monooxygenase, DBH-like 1
NBPF10 neuroblastoma breakpoint family, member 10
NIT1 nitrilase 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
PCBP2 poly(rC) binding protein 2
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RAD51AP1 RAD51 associated protein 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RECQL RecQ helicase-like
REEP1 receptor accessory protein 1
RNASE4 ribonuclease, RNase A family, 4
RPL10 ribosomal protein L10
RRM2 ribonucleotide reductase M2
RSRP1 arginine/serine-rich protein 1
S100A10 S100 calcium binding protein A10
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SHB Src homology 2 domain containing adaptor protein B
SHOX2 short stature homeobox 2
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SOX11 SRY (sex determining region Y)-box 11
SRSF7 serine/arginine-rich splicing factor 7
SSPN sarcospan
STEAP1 six transmembrane epithelial antigen of the prostate 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TM9SF3 transmembrane 9 superfamily member 3
TMEM14A transmembrane protein 14A
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMEM45A transmembrane protein 45A
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
TPD52 tumor protein D52
TRIB1 tribbles pseudokinase 1
TSPAN6 tetraspanin 6
TSPAN8 tetraspanin 8
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WNT5A wingless-type MMTV integration site family, member 5A
WWTR1 WW domain containing transcription regulator 1
XIST X inactive specific transcript (non-protein coding)
ZNF395 zinc finger protein 395
Funding