BRD-K70578146_dactinomycin_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

165 genes differentially expressed following the BRD-K70578146_dactinomycin_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
CALD1 caldesmon 1
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CD44 CD44 molecule (Indian blood group)
CEMIP cell migration inducing protein, hyaluronan binding
CETN2 centrin, EF-hand protein, 2
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL1A2 collagen, type I, alpha 2
COL6A1 collagen, type VI, alpha 1
CTSZ cathepsin Z
DPYSL3 dihydropyrimidinase-like 3
EREG epiregulin
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
GAS6 growth arrest-specific 6
GPM6A glycoprotein M6A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPSE heparanase
IFT57 intraflagellar transport 57
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
LAPTM4B lysosomal protein transmembrane 4 beta
LIMCH1 LIM and calponin homology domains 1
MAOA monoamine oxidase A
MUC16 mucin 16, cell surface associated
NELL2 NEL-like 2 (chicken)
NMU neuromedin U
NPTX2 neuronal pentraxin II
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLS3 plastin 3
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SOX11 SRY (sex determining region Y)-box 11
STC1 stanniocalcin 1
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMSB15A thymosin beta 15a
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1C3 aldo-keto reductase family 1, member C3
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASF1A anti-silencing function 1A histone chaperone
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPA centromere protein A
CGRRF1 cell growth regulator with ring finger domain 1
CHSY1 chondroitin sulfate synthase 1
CKS2 CDC28 protein kinase regulatory subunit 2
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF5 eukaryotic translation initiation factor 5
ESR1 estrogen receptor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEM1B fem-1 homolog b (C. elegans)
FOXJ3 forkhead box J3
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GPRC5A G protein-coupled receptor, class C, group 5, member A
GREB1 growth regulation by estrogen in breast cancer 1
GRWD1 glutamate-rich WD repeat containing 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HEXIM1 hexamethylene bis-acetamide inducible 1
HIC2 hypermethylated in cancer 2
HN1 hematological and neurological expressed 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HSPA14 heat shock 70kDa protein 14
HSPA2 heat shock 70kDa protein 2
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IER3 immediate early response 3
IER5 immediate early response 5
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
ITGB1BP1 integrin beta 1 binding protein 1
JMJD6 jumonji domain containing 6
KIN Kin17 DNA and RNA binding protein
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MED13 mediator complex subunit 13
MLPH melanophilin
MTF2 metal response element binding transcription factor 2
MTSS1 metastasis suppressor 1
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PARP2 poly (ADP-ribose) polymerase 2
PFKP phosphofructokinase, platelet
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
PMP2 peripheral myelin protein 2
PPIF peptidylprolyl isomerase F
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
RBM15 RNA binding motif protein 15
RHOB ras homolog family member B
RNF139 ring finger protein 139
RPP38 ribonuclease P/MRP 38kDa subunit
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERTAD2 SERTA domain containing 2
SFN stratifin
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMAD7 SMAD family member 7
SOX4 SRY (sex determining region Y)-box 4
SPHK1 sphingosine kinase 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBP TATA box binding protein
TBPL1 TBP-like 1
TBX3 T-box 3
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM11 transmembrane protein 11
TNPO1 transportin 1
TRAF4 TNF receptor-associated factor 4
TSKU tsukushi, small leucine rich proteoglycan
TXLNA taxilin alpha
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
ZCCHC2 zinc finger, CCHC domain containing 2
ZFP36L2 ZFP36 ring finger protein-like 2
Funding