BRD-K70792160_Akt inhibitor X_HA1E_24.0_h_24.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K70792160_Akt inhibitor X_HA1E_24.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AIM1 absent in melanoma 1
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLEC2B C-type lectin domain family 2, member B
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DUSP4 dual specificity phosphatase 4
EBP emopamil binding protein (sterol isomerase)
ECM1 extracellular matrix protein 1
ELOVL6 ELOVL fatty acid elongase 6
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GLRX glutaredoxin (thioltransferase)
GPX4 glutathione peroxidase 4
GRN granulin
GUSB glucuronidase, beta
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP2 matrix metallopeptidase 2
MSMO1 methylsterol monooxygenase 1
NGRN neugrin, neurite outgrowth associated
NT5E 5'-nucleotidase, ecto (CD73)
PPL periplakin
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SPP1 secreted phosphoprotein 1
SQLE squalene epoxidase
SQSTM1 sequestosome 1
SREBF2 sterol regulatory element binding transcription factor 2
TM7SF2 transmembrane 7 superfamily member 2
TMEM97 transmembrane protein 97
USP18 ubiquitin specific peptidase 18
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM12 ADAM metallopeptidase domain 12
ADD3 adducin 3 (gamma)
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ASNS asparagine synthetase (glutamine-hydrolyzing)
CCL2 chemokine (C-C motif) ligand 2
CCND2 cyclin D2
CELF2 CUGBP, Elav-like family member 2
CFLAR CASP8 and FADD-like apoptosis regulator
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRYAB crystallin, alpha B
DHRS2 dehydrogenase/reductase (SDR family) member 2
DMD dystrophin
FAM129A family with sequence similarity 129, member A
GLIPR1 GLI pathogenesis-related 1
HOMER2 homer scaffolding protein 2
HPRT1 hypoxanthine phosphoribosyltransferase 1
IGFBP3 insulin-like growth factor binding protein 3
KLC1 kinesin light chain 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID2 nidogen 2 (osteonidogen)
NUP98 nucleoporin 98kDa
OLFM4 olfactomedin 4
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SRPX sushi-repeat containing protein, X-linked
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPM1 tropomyosin 1 (alpha)
UCK2 uridine-cytidine kinase 2
Funding