BRD-K70792160_Akt inhibitor X_HT29_6.0_h_24.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

51 genes differentially expressed following the BRD-K70792160_Akt inhibitor X_HT29_6.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
BMP2 bone morphogenetic protein 2
CD24 CD24 molecule
CDK19 cyclin-dependent kinase 19
CLU clusterin
COLEC12 collectin sub-family member 12
CSTB cystatin B (stefin B)
DDIT4 DNA-damage-inducible transcript 4
F3 coagulation factor III (thromboplastin, tissue factor)
FADS1 fatty acid desaturase 1
GSTP1 glutathione S-transferase pi 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP6 insulin-like growth factor binding protein 6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG1 insulin induced gene 1
JUND jun D proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KRT16 keratin 16, type I
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MFAP5 microfibrillar associated protein 5
MVP major vault protein
MYO6 myosin VI
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPC1 Niemann-Pick disease, type C1
OPTN optineurin
PERP PERP, TP53 apoptosis effector
PRKCD protein kinase C, delta
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLPI secretory leukocyte peptidase inhibitor
SQLE squalene epoxidase
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
CD200 CD200 molecule
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDE4B phosphodiesterase 4B, cAMP-specific
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRGN serglycin
STEAP1 six transmembrane epithelial antigen of the prostate 1
TSPAN13 tetraspanin 13
Funding