BRD-K70792160_Akt inhibitor X_MCF7_24.0_h_24.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

55 genes differentially expressed following the BRD-K70792160_Akt inhibitor X_MCF7_24.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
ALDOC aldolase C, fructose-bisphosphate
BHLHE40 basic helix-loop-helix family, member e40
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
F3 coagulation factor III (thromboplastin, tissue factor)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GRN granulin
HMG20B high mobility group 20B
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPG2 heparan sulfate proteoglycan 2
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KRT14 keratin 14, type I
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MATN2 matrilin 2
MSMO1 methylsterol monooxygenase 1
NDRG1 N-myc downstream regulated 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
RHOB ras homolog family member B
S100A10 S100 calcium binding protein A10
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SQLE squalene epoxidase
SQSTM1 sequestosome 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
ASPN asporin
CKS1B CDC28 protein kinase regulatory subunit 1B
CNPY3 canopy FGF signaling regulator 3
DLC1 DLC1 Rho GTPase activating protein
DPT dermatopontin
GAS1 growth arrest-specific 1
GREM1 gremlin 1, DAN family BMP antagonist
MT1X metallothionein 1X
MTERF3 mitochondrial transcription termination factor 3
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PPIF peptidylprolyl isomerase F
PROM1 prominin 1
PSD3 pleckstrin and Sec7 domain containing 3
SDC2 syndecan 2
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
WIF1 WNT inhibitory factor 1
Funding