BRD-K70792160_Akt inhibitor X_VCAP_6.0_h_24.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K70792160_Akt inhibitor X_VCAP_6.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACACA acetyl-CoA carboxylase alpha
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
ACSL3 acyl-CoA synthetase long-chain family member 3
C10ORF10 chromosome 10 open reading frame 10
C14ORF1 chromosome 14 open reading frame 1
CCL2 chemokine (C-C motif) ligand 2
CCNG2 cyclin G2
CD46 CD46 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CETN2 centrin, EF-hand protein, 2
CLIC4 chloride intracellular channel 4
CYB5A cytochrome b5 type A (microsomal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DSC3 desmocollin 3
DSG3 desmoglein 3
EBP emopamil binding protein (sterol isomerase)
EFNA1 ephrin-A1
ELOVL5 ELOVL fatty acid elongase 5
ELOVL6 ELOVL fatty acid elongase 6
FABP7 fatty acid binding protein 7, brain
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGFBP1 fibroblast growth factor binding protein 1
FN1 fibronectin 1
GLUL glutamate-ammonia ligase
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDI1 isopentenyl-diphosphate delta isomerase 1
IL32 interleukin 32
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOV nephroblastoma overexpressed
NPC1 Niemann-Pick disease, type C1
NSDHL NAD(P) dependent steroid dehydrogenase-like
PANK3 pantothenate kinase 3
PGD phosphogluconate dehydrogenase
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PNRC1 proline-rich nuclear receptor coactivator 1
PPL periplakin
PRKCH protein kinase C, eta
PSAP prosaposin
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCEL sciellin
SDPR serum deprivation response
SEPP1 selenoprotein P, plasma, 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPRR1B small proline-rich protein 1B
SQLE squalene epoxidase
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
STXBP1 syntaxin binding protein 1
TM7SF2 transmembrane 7 superfamily member 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
VGLL4 vestigial-like family member 4
ZBTB18 zinc finger and BTB domain containing 18
ZFAND5 zinc finger, AN1-type domain 5
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
ARMCX2 armadillo repeat containing, X-linked 2
BST2 bone marrow stromal cell antigen 2
CA2 carbonic anhydrase II
F12 coagulation factor XII (Hageman factor)
GDF15 growth differentiation factor 15
GPX7 glutathione peroxidase 7
IFI6 interferon, alpha-inducible protein 6
IGFBP7 insulin-like growth factor binding protein 7
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KRT7 keratin 7, type II
MDK midkine (neurite growth-promoting factor 2)
NID2 nidogen 2 (osteonidogen)
NOP56 NOP56 ribonucleoprotein
NR2F6 nuclear receptor subfamily 2, group F, member 6
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PROM1 prominin 1
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCG5 secretogranin V
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
TRIP6 thyroid hormone receptor interactor 6
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