BRD-K70831943_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-K70831943_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
ALOX5 arachidonate 5-lipoxygenase
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
COPS7A COP9 signalosome subunit 7A
CTSB cathepsin B
FN1 fibronectin 1
GLUL glutamate-ammonia ligase
HMOX1 heme oxygenase 1
HP haptoglobin
IGFBP4 insulin-like growth factor binding protein 4
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LEF1 lymphoid enhancer-binding factor 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NELL2 NEL-like 2 (chicken)
NID2 nidogen 2 (osteonidogen)
PCP4 Purkinje cell protein 4
RGCC regulator of cell cycle
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SORD sorbitol dehydrogenase
SPON1 spondin 1, extracellular matrix protein
TDO2 tryptophan 2,3-dioxygenase
TIMP3 TIMP metallopeptidase inhibitor 3
TSPAN5 tetraspanin 5
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WT1 Wilms tumor 1
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADAMDEC1 ADAM-like, decysin 1
APLP2 amyloid beta (A4) precursor-like protein 2
AQP3 aquaporin 3 (Gill blood group)
CCL19 chemokine (C-C motif) ligand 19
CDC20 cell division cycle 20
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CRABP1 cellular retinoic acid binding protein 1
CSRP1 cysteine and glycine-rich protein 1
CSTA cystatin A (stefin A)
CXCL14 chemokine (C-X-C motif) ligand 14
DPYSL2 dihydropyrimidinase-like 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EI24 etoposide induced 2.4
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FXYD6 FXYD domain containing ion transport regulator 6
GOLGA8H golgin A8 family, member H
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTP1 glutathione S-transferase pi 1
HAT1 histone acetyltransferase 1
HIST1H2BK histone cluster 1, H2bk
HPRT1 hypoxanthine phosphoribosyltransferase 1
ITFG1 integrin alpha FG-GAP repeat containing 1
KRT14 keratin 14, type I
LDLR low density lipoprotein receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LMO2 LIM domain only 2 (rhombotin-like 1)
LYPLA1 lysophospholipase I
MAB21L2 mab-21-like 2 (C. elegans)
MAPK6 mitogen-activated protein kinase 6
MIR22HG MIR22 host gene
MKNK2 MAP kinase interacting serine/threonine kinase 2
MT1E metallothionein 1E
MYH11 myosin, heavy chain 11, smooth muscle
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPY1R neuropeptide Y receptor Y1
NXT2 nuclear transport factor 2-like export factor 2
OXA1L oxidase (cytochrome c) assembly 1-like
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PTN pleiotrophin
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SFRP1 secreted frizzled-related protein 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TDG thymine-DNA glycosylase
TM4SF1 transmembrane 4 L six family member 1
TMC5 transmembrane channel-like 5
UBE3C ubiquitin protein ligase E3C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UFM1 ubiquitin-fold modifier 1
Funding