BRD-K70914287_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K70914287_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACKR3 atypical chemokine receptor 3
ADAMDEC1 ADAM-like, decysin 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHNAK2 AHNAK nucleoprotein 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD10 ankyrin repeat domain 10
APLP2 amyloid beta (A4) precursor-like protein 2
APOC1 apolipoprotein C-I
ASNS asparagine synthetase (glutamine-hydrolyzing)
C8ORF4 chromosome 8 open reading frame 4
CAPG capping protein (actin filament), gelsolin-like
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CDK19 cyclin-dependent kinase 19
CFB complement factor B
CLU clusterin
CNR1 cannabinoid receptor 1 (brain)
COBL cordon-bleu WH2 repeat protein
COL4A2 collagen, type IV, alpha 2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CPVL carboxypeptidase, vitellogenic-like
CST1 cystatin SN
CST3 cystatin C
CTSC cathepsin C
DIO2 deiodinase, iodothyronine, type II
DMBT1 deleted in malignant brain tumors 1
DUSP1 dual specificity phosphatase 1
DUSP22 dual specificity phosphatase 22
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
EFNA1 ephrin-A1
EMP3 epithelial membrane protein 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
INSIG1 insulin induced gene 1
JARID2 jumonji, AT rich interactive domain 2
KCTD5 potassium channel tetramerization domain containing 5
KDM5D lysine (K)-specific demethylase 5D
KIF5C kinesin family member 5C
KRT18 keratin 18, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
KYNU kynureninase
MAP1B microtubule-associated protein 1B
MAP7 microtubule-associated protein 7
MERTK MER proto-oncogene, tyrosine kinase
MMP12 matrix metallopeptidase 12
MPP1 membrane protein, palmitoylated 1, 55kDa
NPC2 Niemann-Pick disease, type C2
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PPAP2B phosphatidic acid phosphatase type 2B
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PSAT1 phosphoserine aminotransferase 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RHOBTB3 Rho-related BTB domain containing 3
RNF19B ring finger protein 19B
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TBX3 T-box 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGIF1 TGFB-induced factor homeobox 1
TNC tenascin C
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TPP1 tripeptidyl peptidase I
TRBC1 T cell receptor beta constant 1
TSC22D1 TSC22 domain family, member 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ARMCX1 armadillo repeat containing, X-linked 1
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
C1ORF54 chromosome 1 open reading frame 54
CD200 CD200 molecule
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC42 cell division cycle 42
CLC Charcot-Leyden crystal galectin
CLEC11A C-type lectin domain family 11, member A
COL1A1 collagen, type I, alpha 1
CRISP3 cysteine-rich secretory protein 3
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTL1 cytokine-like 1
DEFA4 defensin, alpha 4, corticostatin
DUSP6 dual specificity phosphatase 6
ELANE elastase, neutrophil expressed
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FAP fibroblast activation protein, alpha
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
HIST1H1C histone cluster 1, H1c
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
LPAR6 lysophosphatidic acid receptor 6
LRRC17 leucine rich repeat containing 17
LYPD1 LY6/PLAUR domain containing 1
MEIS2 Meis homeobox 2
MFAP5 microfibrillar associated protein 5
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
OLFML3 olfactomedin-like 3
PEG10 paternally expressed 10
PFN2 profilin 2
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLBD1 phospholipase B domain containing 1
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRTN3 proteinase 3
RGCC regulator of cell cycle
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB2A1 secretoglobin, family 2A, member 1
SLPI secretory leukocyte peptidase inhibitor
SRGN serglycin
SULF1 sulfatase 1
TCF4 transcription factor 4
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM30B transmembrane protein 30B
TPM1 tropomyosin 1 (alpha)
TWIST1 twist family bHLH transcription factor 1