BRD-K71199328_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K71199328_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMOTL2 angiomotin like 2
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BIRC3 baculoviral IAP repeat containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
CCL20 chemokine (C-C motif) ligand 20
CCNA1 cyclin A1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
COL14A1 collagen, type XIV, alpha 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GCH1 GTP cyclohydrolase 1
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
ICAM1 intercellular adhesion molecule 1
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IL6 interleukin 6
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
LDLR low density lipoprotein receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MT1X metallothionein 1X
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
PDGFA platelet-derived growth factor alpha polypeptide
PEG10 paternally expressed 10
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SDC4 syndecan 4
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A1 solute carrier family 38, member 1
SNRPE small nuclear ribonucleoprotein polypeptide E
STC2 stanniocalcin 2
TFF3 trefoil factor 3 (intestinal)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TP53BP2 tumor protein p53 binding protein 2
TSC22D1 TSC22 domain family, member 1
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
APP amyloid beta (A4) precursor protein
ATF5 activating transcription factor 5
BAG3 BCL2-associated athanogene 3
CCNG1 cyclin G1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IQGAP2 IQ motif containing GTPase activating protein 2
MDFIC MyoD family inhibitor domain containing
MFAP2 microfibrillar-associated protein 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
TPM1 tropomyosin 1 (alpha)
VCAN versican