BRD-K71303366_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K71303366_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BTN3A3 butyrophilin, subfamily 3, member A3
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD163 CD163 molecule
CGA glycoprotein hormones, alpha polypeptide
CHRDL1 chordin-like 1
CLCN3 chloride channel, voltage-sensitive 3
CNN3 calponin 3, acidic
COTL1 coactosin-like F-actin binding protein 1
CRABP2 cellular retinoic acid binding protein 2
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF5A eukaryotic translation initiation factor 5A
ENO2 enolase 2 (gamma, neuronal)
FN1 fibronectin 1
FOXF1 forkhead box F1
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GRIA2 glutamate receptor, ionotropic, AMPA 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HOXB7 homeobox B7
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IL32 interleukin 32
KCNK3 potassium channel, two pore domain subfamily K, member 3
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT23 keratin 23, type I
LAPTM5 lysosomal protein transmembrane 5
LMO3 LIM domain only 3 (rhombotin-like 2)
MALL mal, T-cell differentiation protein-like
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOB monoamine oxidase B
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSN moesin
MSX1 msh homeobox 1
NUCB2 nucleobindin 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PENK proenkephalin
PLD3 phospholipase D family, member 3
PLIN2 perilipin 2
PRAME preferentially expressed antigen in melanoma
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRSS8 protease, serine, 8
PTN pleiotrophin
PTX3 pentraxin 3, long
RGS10 regulator of G-protein signaling 10
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE4 ribonuclease, RNase A family, 4
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG2 secretogranin II
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SORBS1 sorbin and SH3 domain containing 1
SPON1 spondin 1, extracellular matrix protein
SYT1 synaptotagmin I
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPD52L1 tumor protein D52-like 1
TPSAB1 tryptase alpha/beta 1
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VSIG4 V-set and immunoglobulin domain containing 4

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACD adrenocortical dysplasia homolog (mouse)
ASPN asporin
ATF5 activating transcription factor 5
CCNB1 cyclin B1
CTSG cathepsin G
CXCL13 chemokine (C-X-C motif) ligand 13
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
FST follistatin
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GUSBP11 glucuronidase, beta pseudogene 11
HOMER3 homer scaffolding protein 3
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IGL immunoglobulin lambda locus
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KLF4 Kruppel-like factor 4 (gut)
MMP12 matrix metallopeptidase 12
NUP153 nucleoporin 153kDa
PBX3 pre-B-cell leukemia homeobox 3
PDGFA platelet-derived growth factor alpha polypeptide
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLXNA1 plexin A1
POSTN periostin, osteoblast specific factor
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RALGDS ral guanine nucleotide dissociation stimulator
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SIK1 salt-inducible kinase 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
THBD thrombomodulin
TNPO1 transportin 1
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
WT1 Wilms tumor 1
ZCCHC2 zinc finger, CCHC domain containing 2
Funding