BRD-K71823332_S1297_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

177 genes differentially expressed following the BRD-K71823332_S1297_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACTN4 actinin, alpha 4
BAG2 BCL2-associated athanogene 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD14 CD14 molecule
CD163 CD163 molecule
CLC Charcot-Leyden crystal galectin
COCH cochlin
COL18A1 collagen, type XVIII, alpha 1
CSNK1D casein kinase 1, delta
CXCL8 chemokine (C-X-C motif) ligand 8
DEFA4 defensin, alpha 4, corticostatin
ELANE elastase, neutrophil expressed
EMP3 epithelial membrane protein 3
EPAS1 endothelial PAS domain protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
EREG epiregulin
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FLNA filamin A, alpha
FSCN1 fascin actin-bundling protein 1
FSTL1 follistatin-like 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
H3F3B H3 histone, family 3B (H3.3B)
HCAR3 hydroxycarboxylic acid receptor 3
HMG20B high mobility group 20B
HOMER3 homer scaffolding protein 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
INHBB inhibin, beta B
JMJD6 jumonji domain containing 6
KRT14 keratin 14, type I
LMO4 LIM domain only 4
LPL lipoprotein lipase
LTF lactotransferrin
MAP1B microtubule-associated protein 1B
MFSD12 major facilitator superfamily domain containing 12
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSRA methionine sulfoxide reductase A
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MTA1 metastasis associated 1
NCF1C neutrophil cytosolic factor 1C pseudogene
NTS neurotensin
OBSL1 obscurin-like 1
PKP1 plakophilin 1
PPARG peroxisome proliferator-activated receptor gamma
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRMT1 protein arginine methyltransferase 1
PTX3 pentraxin 3, long
RAP1GAP RAP1 GTPase activating protein
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
SATB2 SATB homeobox 2
SDC2 syndecan 2
SEC62 SEC62 homolog (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
STXBP2 syntaxin binding protein 2
TCL1A T-cell leukemia/lymphoma 1A
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUBB6 tubulin, beta 6 class V
VCAN versican
ZIC1 Zic family member 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AHR aryl hydrocarbon receptor
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARMCX1 armadillo repeat containing, X-linked 1
ASCL1 achaete-scute family bHLH transcription factor 1
ATP9A ATPase, class II, type 9A
BET1 Bet1 golgi vesicular membrane trafficking protein
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCNE2 cyclin E2
CCNF cyclin F
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHEK2 checkpoint kinase 2
COBLL1 cordon-bleu WH2 repeat protein-like 1
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EDNRA endothelin receptor type A
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ESR1 estrogen receptor 1
FAM134B family with sequence similarity 134, member B
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FOXJ3 forkhead box J3
FXYD3 FXYD domain containing ion transport regulator 3
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA3 GATA binding protein 3
GDI2 GDP dissociation inhibitor 2
GNPDA1 glucosamine-6-phosphate deaminase 1
GSPT2 G1 to S phase transition 2
GSTM3 glutathione S-transferase mu 3 (brain)
GUCY1B3 guanylate cyclase 1, soluble, beta 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HADH hydroxyacyl-CoA dehydrogenase
HES1 hes family bHLH transcription factor 1
HIST1H4C histone cluster 1, H4c
HPRT1 hypoxanthine phosphoribosyltransferase 1
IFNGR1 interferon gamma receptor 1
IGF1R insulin-like growth factor 1 receptor
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF2C kinesin family member 2C
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAN2A1 mannosidase, alpha, class 2A, member 1
MELK maternal embryonic leucine zipper kinase
MSH6 mutS homolog 6
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC1 mucin 1, cell surface associated
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOLC1 nucleolar and coiled-body phosphoprotein 1
NRIP1 nuclear receptor interacting protein 1
PCNA proliferating cell nuclear antigen
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RNASE4 ribonuclease, RNase A family, 4
RUFY3 RUN and FYVE domain containing 3
SELT selenoprotein T
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STAG2 stromal antigen 2
SUB1 SUB1 homolog (S. cerevisiae)
SULF1 sulfatase 1
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TM9SF2 transmembrane 9 superfamily member 2
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMED2 transmembrane emp24 domain trafficking protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1
TSPAN6 tetraspanin 6
TXNDC9 thioredoxin domain containing 9
TYMS thymidylate synthetase
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGCG UDP-glucose ceramide glucosyltransferase
VCAM1 vascular cell adhesion molecule 1
WEE1 WEE1 G2 checkpoint kinase
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
ZWINT ZW10 interacting kinetochore protein
Funding