BRD-K72414522_AZD-5438_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

291 genes differentially expressed following the BRD-K72414522_AZD-5438_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AMD1 adenosylmethionine decarboxylase 1
ANKRD10 ankyrin repeat domain 10
ANXA3 annexin A3
ARL4A ADP-ribosylation factor-like 4A
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BMP2 bone morphogenetic protein 2
CCL13 chemokine (C-C motif) ligand 13
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CELF2 CUGBP, Elav-like family member 2
CFB complement factor B
CHERP calcium homeostasis endoplasmic reticulum protein
COL11A1 collagen, type XI, alpha 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
DACH1 dachshund family transcription factor 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DSP desmoplakin
DUSP7 dual specificity phosphatase 7
EFNB2 ephrin-B2
EIF4B eukaryotic translation initiation factor 4B
EREG epiregulin
FAM57A family with sequence similarity 57, member A
FAT1 FAT atypical cadherin 1
FBLN1 fibulin 1
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA2 GATA binding protein 2
GCLC glutamate-cysteine ligase, catalytic subunit
GLUL glutamate-ammonia ligase
GPR88 G protein-coupled receptor 88
GSTT1 glutathione S-transferase theta 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HEBP1 heme binding protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IDO1 indoleamine 2,3-dioxygenase 1
IL18 interleukin 18
IL32 interleukin 32
KIAA0125 KIAA0125
KLF4 Kruppel-like factor 4 (gut)
KLK3 kallikrein-related peptidase 3
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LTF lactotransferrin
LYST lysosomal trafficking regulator
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MLEC malectin
MME membrane metallo-endopeptidase
MMP10 matrix metallopeptidase 10
MXRA5 matrix-remodelling associated 5
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
PALLD palladin, cytoskeletal associated protein
PDE4DIP phosphodiesterase 4D interacting protein
PDIA5 protein disulfide isomerase family A, member 5
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLK2 polo-like kinase 2
PLTP phospholipid transfer protein
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPID peptidylprolyl isomerase D
PPIF peptidylprolyl isomerase F
PPIG peptidylprolyl isomerase G (cyclophilin G)
PRDX2 peroxiredoxin 2
PRR7 proline rich 7 (synaptic)
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PUS7 pseudouridylate synthase 7 (putative)
RALGDS ral guanine nucleotide dissociation stimulator
RNF6 ring finger protein (C3H2C3 type) 6
RNMT RNA (guanine-7-) methyltransferase
RPIA ribose 5-phosphate isomerase A
RSL1D1 ribosomal L1 domain containing 1
SACS sacsin molecular chaperone
SAMD4A sterile alpha motif domain containing 4A
SCML1 sex comb on midleg-like 1 (Drosophila)
SCRIB scribbled planar cell polarity protein
SEPP1 selenoprotein P, plasma, 1
SESN1 sestrin 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOWAHC sosondowah ankyrin repeat domain family member C
SOX9 SRY (sex determining region Y)-box 9
SPEN spen family transcriptional repressor
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STAT5B signal transducer and activator of transcription 5B
STK26 serine/threonine protein kinase 26
STX3 syntaxin 3
TDG thymine-DNA glycosylase
TERT telomerase reverse transcriptase
TMC5 transmembrane channel-like 5
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TPST2 tyrosylprotein sulfotransferase 2
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae)
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VDAC1 voltage-dependent anion channel 1
XIST X inactive specific transcript (non-protein coding)
ZEB2 zinc finger E-box binding homeobox 2
ZFP36L2 ZFP36 ring finger protein-like 2
ZMAT3 zinc finger, matrin-type 3
ZNF195 zinc finger protein 195
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ADGRG2 adhesion G protein-coupled receptor G2
ADI1 acireductone dioxygenase 1
AGR2 anterior gradient 2
AKAP13 A kinase (PRKA) anchor protein 13
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AMIGO2 adhesion molecule with Ig-like domain 2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA1 annexin A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF5 activating transcription factor 5
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C3ORF14 chromosome 3 open reading frame 14
CA12 carbonic anhydrase XII
CADPS2 Ca++-dependent secretion activator 2
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25C cell division cycle 25C
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CIT citron rho-interacting serine/threonine kinase
COL1A2 collagen, type I, alpha 2
CXCL12 chemokine (C-X-C motif) ligand 12
DCN decorin
DEPDC1 DEP domain containing 1
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL2 dihydropyrimidinase-like 2
ECT2 epithelial cell transforming 2
EMP2 epithelial membrane protein 2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ETV1 ets variant 1
FAM129A family with sequence similarity 129, member A
FAM64A family with sequence similarity 64, member A
FGB fibrinogen beta chain
FOXM1 forkhead box M1
FST follistatin
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GALC galactosylceramidase
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLDC glycine dehydrogenase (decarboxylating)
GLRX glutaredoxin (thioltransferase)
GTPBP8 GTP-binding protein 8 (putative)
GTSE1 G-2 and S-phase expressed 1
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HJURP Holliday junction recognition protein
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA2 heat shock 70kDa protein 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
IFI35 interferon-induced protein 35
IFI44 interferon-induced protein 44
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP4 insulin-like growth factor binding protein 4
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
ISG15 ISG15 ubiquitin-like modifier
JCHAIN joining chain of multimeric IgA and IgM
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18A kinesin family member 18A
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KLHDC2 kelch domain containing 2
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LCN2 lipocalin 2
LGALS1 lectin, galactoside-binding, soluble, 1
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LPAR6 lysophosphatidic acid receptor 6
LXN latexin
LY96 lymphocyte antigen 96
MAPK13 mitogen-activated protein kinase 13
MGLL monoglyceride lipase
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MX1 MX dynamin-like GTPase 1
NCAPD2 non-SMC condensin I complex, subunit D2
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NMI N-myc (and STAT) interactor
NPTX1 neuronal pentraxin I
NPTX2 neuronal pentraxin II
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
NUSAP1 nucleolar and spindle associated protein 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OIP5 Opa interacting protein 5
PADI2 peptidyl arginine deiminase, type II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBK PDZ binding kinase
PDE4B phosphodiesterase 4B, cAMP-specific
PDE8A phosphodiesterase 8A
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PLK1 polo-like kinase 1
PLS3 plastin 3
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON3 paraoxonase 3
PRC1 protein regulator of cytokinesis 1
PSAT1 phosphoserine aminotransferase 1
PSIP1 PC4 and SFRS1 interacting protein 1
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RDX radixin
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
RNASE4 ribonuclease, RNase A family, 4
S100P S100 calcium binding protein P
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC16A4 solute carrier family 16, member 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC38A2 solute carrier family 38, member 2
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNAP25 synaptosomal-associated protein, 25kDa
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SRGN serglycin
STMN1 stathmin 1
SYT1 synaptotagmin I
TEX10 testis expressed 10
TFPI2 tissue factor pathway inhibitor 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM50A transmembrane protein 50A
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TTK TTK protein kinase
TUBA1A tubulin, alpha 1a
TUBB4B tubulin, beta 4B class IVb
TXNDC9 thioredoxin domain containing 9
UBE2C ubiquitin-conjugating enzyme E2C
UGP2 UDP-glucose pyrophosphorylase 2
VTCN1 V-set domain containing T cell activation inhibitor 1
WIPF1 WAS/WASL interacting protein family, member 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZEB1 zinc finger E-box binding homeobox 1
Funding