BRD-K72414522_AZD-5438_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K72414522_AZD-5438_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL5 acyl-CoA synthetase long-chain family member 5
ADGRL2 adhesion G protein-coupled receptor L2
ADIRF adipogenesis regulatory factor
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AR androgen receptor
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BCL2A1 BCL2-related protein A1
BIN1 bridging integrator 1
BLNK B-cell linker
C3 complement component 3
CD300A CD300a molecule
CD93 CD93 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
COL11A1 collagen, type XI, alpha 1
CRYAB crystallin, alpha B
EML3 echinoderm microtubule associated protein like 3
ESR1 estrogen receptor 1
EVL Enah/Vasp-like
FCGBP Fc fragment of IgG binding protein
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
FPR1 formyl peptide receptor 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GCLC glutamate-cysteine ligase, catalytic subunit
GJA1 gap junction protein, alpha 1, 43kDa
GOLGA8B golgin A8 family, member B
GPM6B glycoprotein M6B
GPR183 G protein-coupled receptor 183
HBEGF heparin-binding EGF-like growth factor
IGF1 insulin-like growth factor 1 (somatomedin C)
JAM2 junctional adhesion molecule 2
LGALS4 lectin, galactoside-binding, soluble, 4
LIF leukemia inhibitory factor
LY96 lymphocyte antigen 96
MXRA5 matrix-remodelling associated 5
MYRF myelin regulatory factor
OBSL1 obscurin-like 1
OLFM4 olfactomedin 4
PCGF2 polycomb group ring finger 2
PLS1 plastin 1
PPARD peroxisome proliferator-activated receptor delta
PTX3 pentraxin 3, long
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
REG1A regenerating islet-derived 1 alpha
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
RNASET2 ribonuclease T2
RPS4Y1 ribosomal protein S4, Y-linked 1
SPON1 spondin 1, extracellular matrix protein
SRGN serglycin
VCAM1 vascular cell adhesion molecule 1
ZNF586 zinc finger protein 586
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
ADI1 acireductone dioxygenase 1
AIM1 absent in melanoma 1
ANXA1 annexin A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AURKA aurora kinase A
BIRC2 baculoviral IAP repeat containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF62 chromosome 6 open reading frame 62
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNB2 cyclin B2
CCNF cyclin F
CCNG2 cyclin G2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CLCA2 chloride channel accessory 2
CRYM crystallin, mu
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSRP1 cysteine and glycine-rich protein 1
DAAM1 dishevelled associated activator of morphogenesis 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
FAM129A family with sequence similarity 129, member A
FBXO21 F-box protein 21
FN1 fibronectin 1
FST follistatin
GADD45B growth arrest and DNA-damage-inducible, beta
GPSM2 G-protein signaling modulator 2
H1FX H1 histone family, member X
HMG20B high mobility group 20B
HMMR hyaluronan-mediated motility receptor (RHAMM)
IGF1R insulin-like growth factor 1 receptor
IGFBP5 insulin-like growth factor binding protein 5
JADE2 jade family PHD finger 2
JUP junction plakoglobin
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LTBP1 latent transforming growth factor beta binding protein 1
MAOA monoamine oxidase A
MBNL2 muscleblind-like splicing regulator 2
MGLL monoglyceride lipase
MSMB microseminoprotein, beta-
MTSS1 metastasis suppressor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYOF myoferlin
NEK2 NIMA-related kinase 2
NR1D2 nuclear receptor subfamily 1, group D, member 2
NUSAP1 nucleolar and spindle associated protein 1
PDLIM5 PDZ and LIM domain 5
PLK1 polo-like kinase 1
PPAP2B phosphatidic acid phosphatase type 2B
PSIP1 PC4 and SFRS1 interacting protein 1
PTTG1 pituitary tumor-transforming 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A2 solute carrier family 38, member 2
SMC4 structural maintenance of chromosomes 4
TAGLN2 transgelin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMPO thymopoietin
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRIM29 tripartite motif containing 29
TUBB2A tubulin, beta 2A class IIa
TUBB4B tubulin, beta 4B class IVb
UBE2C ubiquitin-conjugating enzyme E2C
YBX3 Y box binding protein 3
Funding