BRD-K72414522_AZD-5438_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K72414522_AZD-5438_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
AP3D1 adaptor-related protein complex 3, delta 1 subunit
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BHLHE41 basic helix-loop-helix family, member e41
CD58 CD58 molecule
CSDE1 cold shock domain containing E1, RNA-binding
CTSZ cathepsin Z
CTTN cortactin
DFNA5 deafness, autosomal dominant 5
DST dystonin
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
F2RL1 coagulation factor II (thrombin) receptor-like 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GPRC5A G protein-coupled receptor, class C, group 5, member A
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
ICAM1 intercellular adhesion molecule 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGB6 integrin, beta 6
KPNB1 karyopherin (importin) beta 1
LAPTM4B lysosomal protein transmembrane 4 beta
LIMCH1 LIM and calponin homology domains 1
LRRN3 leucine rich repeat neuronal 3
MCTP1 multiple C2 domains, transmembrane 1
MECOM MDS1 and EVI1 complex locus
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MMP12 matrix metallopeptidase 12
NPC1 Niemann-Pick disease, type C1
PAX8 paired box 8
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC35F2 solute carrier family 35, member F2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC44A4 solute carrier family 44, member 4
SOX9 SRY (sex determining region Y)-box 9
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TMEM30B transmembrane protein 30B
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TSPAN1 tetraspanin 1
TSPAN3 tetraspanin 3
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADI1 acireductone dioxygenase 1
ADIRF adipogenesis regulatory factor
APOD apolipoprotein D
ARG1 arginase 1
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CCNA2 cyclin A2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL5A2 collagen, type V, alpha 2
COX5B cytochrome c oxidase subunit Vb
COX7B cytochrome c oxidase subunit VIIb
CXCL12 chemokine (C-X-C motif) ligand 12
DEFB1 defensin, beta 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
EAPP E2F-associated phosphoprotein
ELANE elastase, neutrophil expressed
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FXYD2 FXYD domain containing ion transport regulator 2
GATA3 GATA binding protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPNMB glycoprotein (transmembrane) nmb
GYG2 glycogenin 2
HAT1 histone acetyltransferase 1
HBB hemoglobin, beta
HMGA2 high mobility group AT-hook 2
HMGB3 high mobility group box 3
HMOX1 heme oxygenase 1
HOXC10 homeobox C10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
IL1R2 interleukin 1 receptor, type II
INHBE inhibin, beta E
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KIF20A kinesin family member 20A
KRT19 keratin 19, type I
LGALS3 lectin, galactoside-binding, soluble, 3
MXRA7 matrix-remodelling associated 7
MYLK myosin light chain kinase
NDUFA4 NDUFA4, mitochondrial complex associated
NKG7 natural killer cell granule protein 7
NR2F6 nuclear receptor subfamily 2, group F, member 6
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NREP neuronal regeneration related protein
PDGFD platelet derived growth factor D
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RAD51AP1 RAD51 associated protein 1
RGS4 regulator of G-protein signaling 4
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRGN serglycin
SRSF3 serine/arginine-rich splicing factor 3
STMN1 stathmin 1
TCF4 transcription factor 4
TF transferrin
TLE4 transducin-like enhancer of split 4
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMPO thymopoietin
TOX thymocyte selection-associated high mobility group box
TRIB3 tribbles pseudokinase 3
TUBA4A tubulin, alpha 4a
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
Funding