BRD-K72414522_AZD-5438_LNCAP_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-K72414522_AZD-5438_LNCAP_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCY3 adenylate cyclase 3
ADIRF adipogenesis regulatory factor
ALCAM activated leukocyte cell adhesion molecule
AQP9 aquaporin 9
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
BAG6 BCL2-associated athanogene 6
BCHE butyrylcholinesterase
C9ORF16 chromosome 9 open reading frame 16
CAST calpastatin
CD36 CD36 molecule (thrombospondin receptor)
CD40 CD40 molecule, TNF receptor superfamily member 5
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFB complement factor B
CFH complement factor H
CLU clusterin
CNN3 calponin 3, acidic
COCH cochlin
COL9A2 collagen, type IX, alpha 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EPCAM epithelial cell adhesion molecule
FABP4 fatty acid binding protein 4, adipocyte
FAS Fas cell surface death receptor
FBP1 fructose-1,6-bisphosphatase 1
FLRT2 fibronectin leucine rich transmembrane protein 2
G0S2 G0/G1 switch 2
GNB5 guanine nucleotide binding protein (G protein), beta 5
GPD1L glycerol-3-phosphate dehydrogenase 1-like
HEXA hexosaminidase A (alpha polypeptide)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IFI6 interferon, alpha-inducible protein 6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
LPL lipoprotein lipase
LRRC16A leucine rich repeat containing 16A
LTBP3 latent transforming growth factor beta binding protein 3
MAGEA3 melanoma antigen family A3
MDFIC MyoD family inhibitor domain containing
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
MUC16 mucin 16, cell surface associated
MYOF myoferlin
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NTS neurotensin
PCSK6 proprotein convertase subtilisin/kexin type 6
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCH protein kinase C, eta
RCN1 reticulocalbin 1, EF-hand calcium binding domain
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS5 ribosomal protein S5
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPON1 spondin 1, extracellular matrix protein
STEAP1 six transmembrane epithelial antigen of the prostate 1
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TGM2 transglutaminase 2
TM9SF3 transmembrane 9 superfamily member 3
TPM2 tropomyosin 2 (beta)
TSPAN13 tetraspanin 13
UPK1B uroplakin 1B

decreased expression

Symbol Name
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
AURKA aurora kinase A
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAMBI BMP and activin membrane-bound inhibitor
BTG1 B-cell translocation gene 1, anti-proliferative
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2AIP CDKN2A interacting protein
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CREB1 cAMP responsive element binding protein 1
DDIT4 DNA-damage-inducible transcript 4
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
EIF5 eukaryotic translation initiation factor 5
EXO1 exonuclease 1
GEMIN4 gem (nuclear organelle) associated protein 4
GPNMB glycoprotein (transmembrane) nmb
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIC2 hypermethylated in cancer 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IGHD immunoglobulin heavy constant delta
IGKV4-1 immunoglobulin kappa variable 4-1
KEAP1 kelch-like ECH-associated protein 1
KIF18B kinesin family member 18B
LTF lactotransferrin
MAPK6 mitogen-activated protein kinase 6
MARCKSL1 MARCKS-like 1
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MSL2 male-specific lethal 2 homolog (Drosophila)
MTERF3 mitochondrial transcription termination factor 3
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOV nephroblastoma overexpressed
NQO1 NAD(P)H dehydrogenase, quinone 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PITX1 paired-like homeodomain 1
PLAGL2 pleiomorphic adenoma gene-like 2
PLK1 polo-like kinase 1
PRDM2 PR domain containing 2, with ZNF domain
PSRC1 proline/serine-rich coiled-coil 1
RNF19B ring finger protein 19B
RYBP RING1 and YY1 binding protein
SETMAR SET domain and mariner transposase fusion gene
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOX4 SRY (sex determining region Y)-box 4
STIL SCL/TAL1 interrupting locus
SULF1 sulfatase 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNPO1 transportin 1
TUFT1 tuftelin 1
USP1 ubiquitin specific peptidase 1
VGLL4 vestigial-like family member 4
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZCCHC10 zinc finger, CCHC domain containing 10
ZCCHC2 zinc finger, CCHC domain containing 2
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF232 zinc finger protein 232
Funding