BRD-K72414522_AZD-5438_MCF10A_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

299 genes differentially expressed following the BRD-K72414522_AZD-5438_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACKR3 atypical chemokine receptor 3
AGR2 anterior gradient 2
AHNAK2 AHNAK nucleoprotein 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ANKRD10 ankyrin repeat domain 10
ANXA9 annexin A9
ARL4C ADP-ribosylation factor-like 4C
ASS1 argininosuccinate synthase 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCL6 B-cell CLL/lymphoma 6
BIRC3 baculoviral IAP repeat containing 3
BLVRB biliverdin reductase B
C1R complement component 1, r subcomponent
C2CD2 C2 calcium-dependent domain containing 2
C3 complement component 3
CA12 carbonic anhydrase XII
CD300A CD300a molecule
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLEC3B C-type lectin domain family 3, member B
CLU clusterin
COLEC12 collectin sub-family member 12
CPT1A carnitine palmitoyltransferase 1A (liver)
CYB561 cytochrome b561
CYB5R1 cytochrome b5 reductase 1
DACH1 dachshund family transcription factor 1
DDR1 discoidin domain receptor tyrosine kinase 1
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DPT dermatopontin
DSP desmoplakin
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFNA1 ephrin-A1
EMC3 ER membrane protein complex subunit 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPM2AIP1 EPM2A (laforin) interacting protein 1
ESR2 estrogen receptor 2 (ER beta)
ETFB electron-transfer-flavoprotein, beta polypeptide
F13A1 coagulation factor XIII, A1 polypeptide
FAM107A family with sequence similarity 107, member A
FAM127A family with sequence similarity 127, member A
FBLN1 fibulin 1
FOLR1 folate receptor 1 (adult)
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GPC1 glypican 1
GPM6B glycoprotein M6B
GSN gelsolin
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2BFS H2B histone family, member S (pseudogene)
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HLA-C major histocompatibility complex, class I, C
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IFNGR1 interferon gamma receptor 1
IL32 interleukin 32
ITFG1 integrin alpha FG-GAP repeat containing 1
JAM2 junctional adhesion molecule 2
KIAA0125 KIAA0125
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KRT8 keratin 8, type II
L1CAM L1 cell adhesion molecule
LAMB2 laminin, beta 2 (laminin S)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MFAP5 microfibrillar associated protein 5
MMD monocyte to macrophage differentiation-associated
MMP7 matrix metallopeptidase 7
MSX2 msh homeobox 2
MUC16 mucin 16, cell surface associated
MXRA5 matrix-remodelling associated 5
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
NUP210 nucleoporin 210kDa
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM1 olfactomedin 1
OLFML2A olfactomedin-like 2A
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PDZK1IP1 PDZK1 interacting protein 1
PEG10 paternally expressed 10
PHF20 PHD finger protein 20
PI3 peptidase inhibitor 3, skin-derived
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLXNB2 plexin B2
PON2 paraoxonase 2
PPAP2B phosphatidic acid phosphatase type 2B
PPL periplakin
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRSS8 protease, serine, 8
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASET2 ribonuclease T2
RSL1D1 ribosomal L1 domain containing 1
S100A7 S100 calcium binding protein A7
SAT1 spermidine/spermine N1-acetyltransferase 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SFN stratifin
SGCE sarcoglycan, epsilon
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC46A3 solute carrier family 46, member 3
SLPI secretory leukocyte peptidase inhibitor
SNN stannin
SPARCL1 SPARC-like 1 (hevin)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPON1 spondin 1, extracellular matrix protein
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC2 stanniocalcin 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TM9SF4 transmembrane 9 superfamily protein member 4
TMEM45A transmembrane protein 45A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TPD52L1 tumor protein D52-like 1
TPGS2 tubulin polyglutamylase complex subunit 2
TPP1 tripeptidyl peptidase I
TRIM16 tripartite motif containing 16
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TSPAN1 tetraspanin 1
VCAM1 vascular cell adhesion molecule 1
WWC1 WW and C2 domain containing 1
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF423 zinc finger protein 423
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
ADI1 acireductone dioxygenase 1
AMIGO2 adhesion molecule with Ig-like domain 2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANPEP alanyl (membrane) aminopeptidase
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
AURKA aurora kinase A
AURKB aurora kinase B
BCLAF1 BCL2-associated transcription factor 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB3 BUB3 mitotic checkpoint protein
C4BPA complement component 4 binding protein, alpha
CALR calreticulin
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CIT citron rho-interacting serine/threonine kinase
CKAP4 cytoskeleton-associated protein 4
CKS2 CDC28 protein kinase regulatory subunit 2
CLC Charcot-Leyden crystal galectin
CPNE3 copine III
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL9 chemokine (C-X-C motif) ligand 9
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
CYR61 cysteine-rich, angiogenic inducer, 61
DDAH1 dimethylarginine dimethylaminohydrolase 1
DEPDC1 DEP domain containing 1
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DOCK4 dedicator of cytokinesis 4
EGR1 early growth response 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FAM64A family with sequence similarity 64, member A
FGF13 fibroblast growth factor 13
FOXM1 forkhead box M1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GSTO1 glutathione S-transferase omega 1
GTPBP8 GTP-binding protein 8 (putative)
GTSE1 G-2 and S-phase expressed 1
GYG1 glycogenin 1
GZMK granzyme K (granzyme 3; tryptase II)
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXC6 homeobox C6
HPRT1 hypoxanthine phosphoribosyltransferase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IL13RA2 interleukin 13 receptor, alpha 2
IL1B interleukin 1, beta
IL7R interleukin 7 receptor
ITGA6 integrin, alpha 6
ITM2A integral membrane protein 2A
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
LAMP5 lysosomal-associated membrane protein family, member 5
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LBR lamin B receptor
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKSL1 MARCKS-like 1
MCM5 minichromosome maintenance complex component 5
MICALL1 MICAL-like 1
MKI67 marker of proliferation Ki-67
MMP9 matrix metallopeptidase 9
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NBN nibrin
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NEK7 NIMA-related kinase 7
NPY neuropeptide Y
NTS neurotensin
NUSAP1 nucleolar and spindle associated protein 1
OSBPL8 oxysterol binding protein-like 8
PAIP1 poly(A) binding protein interacting protein 1
PBK PDZ binding kinase
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RGS2 regulator of G-protein signaling 2
SEPHS1 selenophosphate synthetase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SKP1 S-phase kinase-associated protein 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLIT2 slit homolog 2 (Drosophila)
SMAGP small cell adhesion glycoprotein
SMC4 structural maintenance of chromosomes 4
SMS spermine synthase
SMYD2 SET and MYND domain containing 2
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPG small nuclear ribonucleoprotein polypeptide G
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
SRSF3 serine/arginine-rich splicing factor 3
STMN1 stathmin 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC3 transforming, acidic coiled-coil containing protein 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM50A transmembrane protein 50A
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TTK TTK protein kinase
TUSC3 tumor suppressor candidate 3
TWF1 twinfilin actin binding protein 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
WNT5A wingless-type MMTV integration site family, member 5A
Funding