BRD-K72414522_AZD-5438_PC3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

53 genes differentially expressed following the BRD-K72414522_AZD-5438_PC3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACTA2 actin, alpha 2, smooth muscle, aorta
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMPD3 adenosine monophosphate deaminase 3
BHLHE40 basic helix-loop-helix family, member e40
CA12 carbonic anhydrase XII
CD34 CD34 molecule
CD44 CD44 molecule (Indian blood group)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CKB creatine kinase, brain
CTSZ cathepsin Z
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EFHD1 EF-hand domain family, member D1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHB2 EPH receptor B2
IL32 interleukin 32
IL6 interleukin 6
KIAA0930 KIAA0930
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MLPH melanophilin
MYLK myosin light chain kinase
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NUPR1 nuclear protein, transcriptional regulator, 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLAGL1 pleiomorphic adenoma gene-like 1
RBKS ribokinase
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SH3BP4 SH3-domain binding protein 4
TGM2 transglutaminase 2

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CEP57 centrosomal protein 57kDa
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
HP haptoglobin
MNDA myeloid cell nuclear differentiation antigen
NGRN neugrin, neurite outgrowth associated
NRN1 neuritin 1
PCDH9 protocadherin 9
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PRKCI protein kinase C, iota
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
Funding