BRD-K72414522_AZD-5438_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

198 genes differentially expressed following the BRD-K72414522_AZD-5438_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABAT 4-aminobutyrate aminotransferase
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
AGR2 anterior gradient 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANO1 anoctamin 1, calcium activated chloride channel
AREG amphiregulin
ASS1 argininosuccinate synthase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BLNK B-cell linker
C3 complement component 3
CA12 carbonic anhydrase XII
CA9 carbonic anhydrase IX
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CFB complement factor B
CHGB chromogranin B
CSRP2 cysteine and glycine-rich protein 2
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
DDR1 discoidin domain receptor tyrosine kinase 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSG2 desmoglein 2
DSP desmoplakin
EDNRA endothelin receptor type A
EGFL6 EGF-like-domain, multiple 6
ESR1 estrogen receptor 1
FAM57A family with sequence similarity 57, member A
FGFBP1 fibroblast growth factor binding protein 1
GAA glucosidase, alpha; acid
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GJA1 gap junction protein, alpha 1, 43kDa
GPC3 glypican 3
GRAMD4 GRAM domain containing 4
GRB10 growth factor receptor-bound protein 10
HCP5 HLA complex P5 (non-protein coding)
HOPX HOP homeobox
IFI27 interferon, alpha-inducible protein 27
IL32 interleukin 32
IRF6 interferon regulatory factor 6
KCNK1 potassium channel, two pore domain subfamily K, member 1
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGALS4 lectin, galactoside-binding, soluble, 4
LPCAT1 lysophosphatidylcholine acyltransferase 1
LTF lactotransferrin
MAOB monoamine oxidase B
MAP7 microtubule-associated protein 7
MCOLN1 mucolipin 1
MUC1 mucin 1, cell surface associated
MXRA5 matrix-remodelling associated 5
MYO5C myosin VC
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEBL nebulette
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NPDC1 neural proliferation, differentiation and control, 1
OPN3 opsin 3
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PALLD palladin, cytoskeletal associated protein
PCP4 Purkinje cell protein 4
PCSK6 proprotein convertase subtilisin/kexin type 6
PEG10 paternally expressed 10
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLVAP plasmalemma vesicle associated protein
PON2 paraoxonase 2
PPARD peroxisome proliferator-activated receptor delta
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A14 S100 calcium binding protein A14
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFN stratifin
SFTPB surfactant protein B
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
ST14 suppression of tumorigenicity 14 (colon carcinoma)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SYBU syntabulin (syntaxin-interacting)
SYNGR2 synaptogyrin 2
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TFF3 trefoil factor 3 (intestinal)
TMEM176B transmembrane protein 176B
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TSPAN1 tetraspanin 1
TSPAN3 tetraspanin 3
VLDLR very low density lipoprotein receptor
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADI1 acireductone dioxygenase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF5 activating transcription factor 5
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C6ORF62 chromosome 6 open reading frame 62
CAV1 caveolin 1, caveolae protein, 22kDa
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CDCA3 cell division cycle associated 3
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CREB1 cAMP responsive element binding protein 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYR61 cysteine-rich, angiogenic inducer, 61
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPS8 epidermal growth factor receptor pathway substrate 8
EVI2A ecotropic viral integration site 2A
FAM129A family with sequence similarity 129, member A
GALC galactosylceramidase
GTPBP8 GTP-binding protein 8 (putative)
GTSE1 G-2 and S-phase expressed 1
H2AFV H2A histone family, member V
H2AFX H2A histone family, member X
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXC6 homeobox C6
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IL7R interleukin 7 receptor
JADE2 jade family PHD finger 2
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18A kinesin family member 18A
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KRT15 keratin 15, type I
MKI67 marker of proliferation Ki-67
MMP1 matrix metallopeptidase 1
MNDA myeloid cell nuclear differentiation antigen
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NOTCH2NL notch 2 N-terminal like
NRGN neurogranin (protein kinase C substrate, RC3)
OSBPL8 oxysterol binding protein-like 8
PBK PDZ binding kinase
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PPIE peptidylprolyl isomerase E (cyclophilin E)
PSRC1 proline/serine-rich coiled-coil 1
RDX radixin
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC38A2 solute carrier family 38, member 2
SMC4 structural maintenance of chromosomes 4
SMS spermine synthase
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
THUMPD1 THUMP domain containing 1
TMEM50A transmembrane protein 50A
TOP2A topoisomerase (DNA) II alpha 170kDa
TTK TTK protein kinase
WNT5A wingless-type MMTV integration site family, member 5A
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
Funding