BRD-K72451865_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-K72451865_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOD apolipoprotein D
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BHLHE41 basic helix-loop-helix family, member e41
C10ORF10 chromosome 10 open reading frame 10
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD24 CD24 molecule
CD9 CD9 molecule
CLIC4 chloride intracellular channel 4
COG5 component of oligomeric golgi complex 5
CRABP2 cellular retinoic acid binding protein 2
CSRP1 cysteine and glycine-rich protein 1
DDIT4 DNA-damage-inducible transcript 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ELL2 elongation factor, RNA polymerase II, 2
EMP1 epithelial membrane protein 1
ERBB3 erb-b2 receptor tyrosine kinase 3
EZR ezrin
FOSL2 FOS-like antigen 2
GADD45B growth arrest and DNA-damage-inducible, beta
GCLC glutamate-cysteine ligase, catalytic subunit
GSN gelsolin
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
IGF1R insulin-like growth factor 1 receptor
IGL immunoglobulin lambda locus
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRT13 keratin 13, type I
KRT18 keratin 18, type I
KRT5 keratin 5, type II
LDLR low density lipoprotein receptor
LPL lipoprotein lipase
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MGP matrix Gla protein
MTA1 metastasis associated 1
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO6 myosin VI
MYOF myoferlin
NBR1 neighbor of BRCA1 gene 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PER1 period circadian clock 1
PPIC peptidylprolyl isomerase C (cyclophilin C)
PSAP prosaposin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAP1GAP RAP1 GTPase activating protein
RHOB ras homolog family member B
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELE selectin E
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SIK1 salt-inducible kinase 1
SOX4 SRY (sex determining region Y)-box 4
TBX3 T-box 3
TF transferrin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TM4SF1 transmembrane 4 L six family member 1
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TTN titin
VEGFA vascular endothelial growth factor A
YBX3 Y box binding protein 3
ZBTB20 zinc finger and BTB domain containing 20
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ALDOB aldolase B, fructose-bisphosphate
AP5M1 adaptor-related protein complex 5, mu 1 subunit
ATF5 activating transcription factor 5
AURKA aurora kinase A
C14ORF2 chromosome 14 open reading frame 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCL8 chemokine (C-C motif) ligand 8
CDC25A cell division cycle 25A
CDKN3 cyclin-dependent kinase inhibitor 3
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CLGN calmegin
CNIH1 cornichon family AMPA receptor auxiliary protein 1
CXCL12 chemokine (C-X-C motif) ligand 12
DEFA4 defensin, alpha 4, corticostatin
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF1AX eukaryotic translation initiation factor 1A, X-linked
F5 coagulation factor V (proaccelerin, labile factor)
FASTKD5 FAST kinase domains 5
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GCH1 GTP cyclohydrolase 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLGA8A golgin A8 family, member A
HHEX hematopoietically expressed homeobox
HSPA1A heat shock 70kDa protein 1A
IL13RA2 interleukin 13 receptor, alpha 2
JMJD6 jumonji domain containing 6
LRRN3 leucine rich repeat neuronal 3
MAN1A1 mannosidase, alpha, class 1A, member 1
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MOAP1 modulator of apoptosis 1
PAX5 paired box 5
PCDH9 protocadherin 9
PDCD2 programmed cell death 2
PLK1 polo-like kinase 1
PLXNC1 plexin C1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPIF peptidylprolyl isomerase F
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PTX3 pentraxin 3, long
RAE1 ribonucleic acid export 1
RPL36AL ribosomal protein L36a-like
SFPQ splicing factor proline/glutamine-rich
SLBP stem-loop binding protein
TCL1A T-cell leukemia/lymphoma 1A
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TSPYL5 TSPY-like 5
TUBA4A tubulin, alpha 4a
WT1 Wilms tumor 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)