| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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191 genes differentially expressed following the BRD-K72541103_JAK3 Inhibitor I_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ADAM10 | ADAM metallopeptidase domain 10 |
| AKR1C1 | aldo-keto reductase family 1, member C1 |
| AKR1C2 | aldo-keto reductase family 1, member C2 |
| AKR1C3 | aldo-keto reductase family 1, member C3 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 |
| ALOX5 | arachidonate 5-lipoxygenase |
| ANXA4 | annexin A4 |
| ANXA9 | annexin A9 |
| ARG2 | arginase 2 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) |
| ASS1 | argininosuccinate synthase 1 |
| BEX4 | brain expressed, X-linked 4 |
| BLNK | B-cell linker |
| C10ORF10 | chromosome 10 open reading frame 10 |
| C3 | complement component 3 |
| CALD1 | caldesmon 1 |
| CD24 | CD24 molecule |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta |
| CFD | complement factor D (adipsin) |
| CLDN3 | claudin 3 |
| CRABP2 | cellular retinoic acid binding protein 2 |
| CRYAB | crystallin, alpha B |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 |
| DEPTOR | DEP domain containing MTOR-interacting protein |
| DIO1 | deiodinase, iodothyronine, type I |
| EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) |
| FBLN1 | fibulin 1 |
| FGB | fibrinogen beta chain |
| FGFR2 | fibroblast growth factor receptor 2 |
| FGG | fibrinogen gamma chain |
| FN1 | fibronectin 1 |
| GRN | granulin |
| GSTA1 | glutathione S-transferase alpha 1 |
| HIST1H1C | histone cluster 1, H1c |
| HIST1H2AC | histone cluster 1, H2ac |
| HIST1H2BD | histone cluster 1, H2bd |
| IFT57 | intraflagellar transport 57 |
| IGHM | immunoglobulin heavy constant mu |
| INSM1 | insulinoma-associated 1 |
| KRT19 | keratin 19, type I |
| KRT4 | keratin 4, type II |
| LDOC1 | leucine zipper, down-regulated in cancer 1 |
| LPAR6 | lysophosphatidic acid receptor 6 |
| MAOA | monoamine oxidase A |
| METTL7A | methyltransferase like 7A |
| MME | membrane metallo-endopeptidase |
| MMP7 | matrix metallopeptidase 7 |
| MSMB | microseminoprotein, beta- |
| MUC1 | mucin 1, cell surface associated |
| NEB | nebulin |
| NUPR1 | nuclear protein, transcriptional regulator, 1 |
| NXN | nucleoredoxin |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) |
| PDZK1IP1 | PDZK1 interacting protein 1 |
| PEG10 | paternally expressed 10 |
| PEG3 | paternally expressed 3 |
| PEX11A | peroxisomal biogenesis factor 11 alpha |
| PLXNB2 | plexin B2 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C |
| PYCARD | PYD and CARD domain containing |
| RAB21 | RAB21, member RAS oncogene family |
| RGCC | regulator of cell cycle |
| RTN1 | reticulon 1 |
| S100A8 | S100 calcium binding protein A8 |
| SCD5 | stearoyl-CoA desaturase 5 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit |
| SCPEP1 | serine carboxypeptidase 1 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 |
| SGCE | sarcoglycan, epsilon |
| SLC7A7 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 |
| STON1 | stonin 1 |
| SULF1 | sulfatase 1 |
| SULT1A1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 |
| TCTA | T-cell leukemia translocation altered |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 |
| TPD52L1 | tumor protein D52-like 1 |
| TSC22D3 | TSC22 domain family, member 3 |
| TTC39A | tetratricopeptide repeat domain 39A |
| UBE2J1 | ubiquitin-conjugating enzyme E2, J1 |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) |
| UGDH | UDP-glucose 6-dehydrogenase |
| VAMP8 | vesicle-associated membrane protein 8 |
| VPS28 | vacuolar protein sorting 28 homolog (S. cerevisiae) |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 |
| YPEL5 | yippee-like 5 (Drosophila) |
| ZHX2 | zinc fingers and homeoboxes 2 |
| ZSCAN18 | zinc finger and SCAN domain containing 18 |
| Symbol | Name |
|---|---|
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 |
| ASF1B | anti-silencing function 1B histone chaperone |
| AURKA | aurora kinase A |
| BATF3 | basic leucine zipper transcription factor, ATF-like 3 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A |
| BLM | Bloom syndrome, RecQ helicase-like |
| CANT1 | calcium activated nucleotidase 1 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase |
| CCL18 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) |
| CCNA2 | cyclin A2 |
| CCND1 | cyclin D1 |
| CCNF | cyclin F |
| CDC25A | cell division cycle 25A |
| CDC6 | cell division cycle 6 |
| CDK1 | cyclin-dependent kinase 1 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 |
| CETN3 | centrin, EF-hand protein, 3 |
| CHL1 | cell adhesion molecule L1-like |
| CIT | citron rho-interacting serine/threonine kinase |
| CKS2 | CDC28 protein kinase regulatory subunit 2 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 |
| DHFR | dihydrofolate reductase |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
| DUSP4 | dual specificity phosphatase 4 |
| DUSP6 | dual specificity phosphatase 6 |
| DUSP7 | dual specificity phosphatase 7 |
| EFNB2 | ephrin-B2 |
| EPN2 | epsin 2 |
| ETV1 | ets variant 1 |
| ETV5 | ets variant 5 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) |
| FAM129A | family with sequence similarity 129, member A |
| FGFR3 | fibroblast growth factor receptor 3 |
| FOSL1 | FOS-like antigen 1 |
| G0S2 | G0/G1 switch 2 |
| HBEGF | heparin-binding EGF-like growth factor |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 |
| HMGA1 | high mobility group AT-hook 1 |
| HOMER1 | homer scaffolding protein 1 |
| HOPX | HOP homeobox |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) |
| IER3 | immediate early response 3 |
| IL13RA2 | interleukin 13 receptor, alpha 2 |
| ITM2A | integral membrane protein 2A |
| JADE2 | jade family PHD finger 2 |
| KIAA0101 | KIAA0101 |
| KIF14 | kinesin family member 14 |
| KLF4 | Kruppel-like factor 4 (gut) |
| LAMC2 | laminin, gamma 2 |
| LIF | leukemia inhibitory factor |
| LPAR1 | lysophosphatidic acid receptor 1 |
| MFHAS1 | malignant fibrous histiocytoma amplified sequence 1 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase |
| PBK | PDZ binding kinase |
| PLAC8 | placenta-specific 8 |
| PLAT | plasminogen activator, tissue |
| PLAUR | plasminogen activator, urokinase receptor |
| PMP22 | peripheral myelin protein 22 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit |
| PPIF | peptidylprolyl isomerase F |
| PRR7 | proline rich 7 (synaptic) |
| RAD51C | RAD51 paralog C |
| RGS2 | regulator of G-protein signaling 2 |
| RPA3 | replication protein A3, 14kDa |
| RPL37A | ribosomal protein L37a |
| RPL38 | ribosomal protein L38 |
| RPS11 | ribosomal protein S11 |
| S100A2 | S100 calcium binding protein A2 |
| SACS | sacsin molecular chaperone |
| SATB2 | SATB homeobox 2 |
| SFTPA2 | surfactant protein A2 |
| SFTPB | surfactant protein B |
| SHCBP1 | SHC SH2-domain binding protein 1 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 |
| SLC25A15 | solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 |
| SLIRP | SRA stem-loop interacting RNA binding protein |
| SOX9 | SRY (sex determining region Y)-box 9 |
| SPRR1A | small proline-rich protein 1A |
| SPRR1B | small proline-rich protein 1B |
| SPRY2 | sprouty homolog 2 (Drosophila) |
| SRSF6 | serine/arginine-rich splicing factor 6 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) |
| SYNJ2 | synaptojanin 2 |
| TFF3 | trefoil factor 3 (intestinal) |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 |
| TNC | tenascin C |
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 |
| TPBG | trophoblast glycoprotein |
| TRIP13 | thyroid hormone receptor interactor 13 |
| TSPAN8 | tetraspanin 8 |
| TYMS | thymidylate synthetase |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 |
| UBE2S | ubiquitin-conjugating enzyme E2S |
| UBR7 | ubiquitin protein ligase E3 component n-recognin 7 (putative) |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 |
| ZWINT | ZW10 interacting kinetochore protein |
