BRD-K72615639_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

138 genes differentially expressed following the BRD-K72615639_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
ALDOC aldolase C, fructose-bisphosphate
APOD apolipoprotein D
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CLU clusterin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFHD1 EF-hand domain family, member D1
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
ENO2 enolase 2 (gamma, neuronal)
FOSL2 FOS-like antigen 2
G0S2 G0/G1 switch 2
GLRX glutaredoxin (thioltransferase)
GPM6B glycoprotein M6B
GSE1 Gse1 coiled-coil protein
GSTM3 glutathione S-transferase mu 3 (brain)
HBEGF heparin-binding EGF-like growth factor
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HLA-B major histocompatibility complex, class I, B
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
INHBA inhibin, beta A
INSIG2 insulin induced gene 2
JUN jun proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM3A lysine (K)-specific demethylase 3A
KDM7A lysine (K)-specific demethylase 7A
KLF10 Kruppel-like factor 10
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LIF leukemia inhibitory factor
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MT1G metallothionein 1G
MT1M metallothionein 1M
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
MZB1 marginal zone B and B1 cell-specific protein
N4BP2L2 NEDD4 binding protein 2-like 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PGK1 phosphoglycerate kinase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
RAB20 RAB20, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RIOK3 RIO kinase 3
SCGB2A1 secretoglobin, family 2A, member 1
SERTAD2 SERTA domain containing 2
SH3YL1 SH3 and SYLF domain containing 1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOX9 SRY (sex determining region Y)-box 9
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TES testin LIM domain protein
TGIF1 TGFB-induced factor homeobox 1
TMEM45A transmembrane protein 45A
TRIM22 tripartite motif containing 22
TXNIP thioredoxin interacting protein
UBXN4 UBX domain protein 4
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADGRL1 adhesion G protein-coupled receptor L1
AKR1C3 aldo-keto reductase family 1, member C3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
AURKA aurora kinase A
B3GNT1
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
C14ORF169 chromosome 14 open reading frame 169
CCNA2 cyclin A2
CCND1 cyclin D1
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CXCL5 chemokine (C-X-C motif) ligand 5
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
H2BFS H2B histone family, member S (pseudogene)
HMGA2 high mobility group AT-hook 2
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IFRD2 interferon-related developmental regulator 2
IQGAP2 IQ motif containing GTPase activating protein 2
JADE2 jade family PHD finger 2
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LBR lamin B receptor
MECOM MDS1 and EVI1 complex locus
MLEC malectin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NUP62 nucleoporin 62kDa
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PODXL podocalyxin-like
PON2 paraoxonase 2
PSCA prostate stem cell antigen
PTTG1 pituitary tumor-transforming 1
RAD9A RAD9 homolog A (S. pombe)
TACC3 transforming, acidic coiled-coil containing protein 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM14 tripartite motif containing 14
UBE2S ubiquitin-conjugating enzyme E2S