BRD-K72636697_QL-X-138_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

164 genes differentially expressed following the BRD-K72636697_QL-X-138_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADGRG6 adhesion G protein-coupled receptor G6
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
BEX1 brain expressed, X-linked 1
BMP4 bone morphogenetic protein 4
C14ORF159 chromosome 14 open reading frame 159
C6ORF48 chromosome 6 open reading frame 48
CCND2 cyclin D2
CD93 CD93 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHGB chromogranin B
CKB creatine kinase, brain
CSNK1D casein kinase 1, delta
CXADR coxsackie virus and adenovirus receptor
DACH1 dachshund family transcription factor 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL2 dihydropyrimidinase-like 2
DUSP6 dual specificity phosphatase 6
FILIP1L filamin A interacting protein 1-like
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GLTSCR2 glioma tumor suppressor candidate region gene 2
GSDMB gasdermin B
INA internexin neuronal intermediate filament protein, alpha
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
LCK LCK proto-oncogene, Src family tyrosine kinase
LTA4H leukotriene A4 hydrolase
NDC80 NDC80 kinetochore complex component
NEBL nebulette
NELL2 NEL-like 2 (chicken)
OSBPL10 oxysterol binding protein-like 10
PNMA2 paraneoplastic Ma antigen 2
POSTN periostin, osteoblast specific factor
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PTCH1 patched 1
RAP1GAP2 RAP1 GTPase activating protein 2
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RGS5 regulator of G-protein signaling 5
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SLC38A1 solute carrier family 38, member 1
SNAP25 synaptosomal-associated protein, 25kDa
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX1 sorting nexin 1
SORBS1 sorbin and SH3 domain containing 1
SOX4 SRY (sex determining region Y)-box 4
SPRY2 sprouty homolog 2 (Drosophila)
STMN2 stathmin 2
STON1 stonin 1
SULF1 sulfatase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNE2 spectrin repeat containing, nuclear envelope 2
SYT1 synaptotagmin I
TMEM158 transmembrane protein 158 (gene/pseudogene)
TSPAN7 tetraspanin 7
UBE2I ubiquitin-conjugating enzyme E2I
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCAN versican
VSNL1 visinin-like 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACP5 acid phosphatase 5, tartrate resistant
ADAM12 ADAM metallopeptidase domain 12
ADGRG1 adhesion G protein-coupled receptor G1
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CD47 CD47 molecule
CD58 CD58 molecule
CFH complement factor H
CLN5 ceroid-lipofuscinosis, neuronal 5
CTSZ cathepsin Z
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELL2 elongation factor, RNA polymerase II, 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM129A family with sequence similarity 129, member A
FAM162A family with sequence similarity 162, member A
FASTKD3 FAST kinase domains 3
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GLRX2 glutaredoxin 2
GPI glucose-6-phosphate isomerase
GPX3 glutathione peroxidase 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HP haptoglobin
HSPB8 heat shock 22kDa protein 8
HYOU1 hypoxia up-regulated 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLV2-23 immunoglobulin lambda variable 2-23
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0125 KIAA0125
LAMC1 laminin, gamma 1 (formerly LAMB2)
LMO4 LIM domain only 4
LY6D lymphocyte antigen 6 complex, locus D
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSMO1 methylsterol monooxygenase 1
NQO1 NAD(P)H dehydrogenase, quinone 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDX2 peroxiredoxin 2
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
QPRT quinolinate phosphoribosyltransferase
SAR1B secretion associated, Ras related GTPase 1B
SC5D sterol-C5-desaturase
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SQLE squalene epoxidase
SRPRB signal recognition particle receptor, B subunit
STC1 stanniocalcin 1
STC2 stanniocalcin 2
SUB1 SUB1 homolog (S. cerevisiae)
TARS threonyl-tRNA synthetase
TFRC transferrin receptor
TGFBI transforming growth factor, beta-induced, 68kDa
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TWF1 twinfilin actin binding protein 1
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
XBP1 X-box binding protein 1
Funding