BRD-K72636697_QL-X-138_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-K72636697_QL-X-138_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AQP3 aquaporin 3 (Gill blood group)
CD9 CD9 molecule
CRABP1 cellular retinoic acid binding protein 1
CRIP2 cysteine-rich protein 2
CTGF connective tissue growth factor
DSP desmoplakin
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
HIST1H2AC histone cluster 1, H2ac
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
ITGB5 integrin, beta 5
KRT18 keratin 18, type I
KYNU kynureninase
LEF1 lymphoid enhancer-binding factor 1
LXN latexin
MMP9 matrix metallopeptidase 9
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NT5E 5'-nucleotidase, ecto (CD73)
OXA1L oxidase (cytochrome c) assembly 1-like
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POSTN periostin, osteoblast specific factor
PTCH1 patched 1
QPCT glutaminyl-peptide cyclotransferase
RAB25 RAB25, member RAS oncogene family
RBM47 RNA binding motif protein 47
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THSD7A thrombospondin, type I, domain containing 7A
TM4SF1 transmembrane 4 L six family member 1
TRPS1 trichorhinophalangeal syndrome I
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VIM vimentin
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
CCNA2 cyclin A2
CPB1 carboxypeptidase B1 (tissue)
CTSE cathepsin E
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
EBP emopamil binding protein (sterol isomerase)
GSTA1 glutathione S-transferase alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LPL lipoprotein lipase
MCAM melanoma cell adhesion molecule
MN1 meningioma (disrupted in balanced translocation) 1
PDZK1 PDZ domain containing 1
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK1 serine peptidase inhibitor, Kazal type 1
TLK2 tousled-like kinase 2
ZNF395 zinc finger protein 395
Funding