BRD-K72723676_Benzethonium chloride_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

230 genes differentially expressed following the BRD-K72723676_Benzethonium chloride_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ALDOB aldolase B, fructose-bisphosphate
AMOTL2 angiomotin like 2
ANXA1 annexin A1
ANXA3 annexin A3
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
BLNK B-cell linker
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC28A coiled-coil domain containing 28A
CCDC92 coiled-coil domain containing 92
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCA4 chloride channel accessory 4
CRISP3 cysteine-rich secretory protein 3
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSG3 desmoglein 3
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOLR1 folate receptor 1 (adult)
FOXO4 forkhead box O4
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GREM1 gremlin 1, DAN family BMP antagonist
GTPBP2 GTP binding protein 2
HBP1 HMG-box transcription factor 1
HDAC6 histone deacetylase 6
HDLBP high density lipoprotein binding protein
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
INSIG1 insulin induced gene 1
IRF9 interferon regulatory factor 9
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF5 Kruppel-like factor 5 (intestinal)
KLF9 Kruppel-like factor 9
KRT81 keratin 81, type II
KYNU kynureninase
LARP6 La ribonucleoprotein domain family, member 6
LGALS4 lectin, galactoside-binding, soluble, 4
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MAP2K5 mitogen-activated protein kinase kinase 5
MSLN mesothelin
NCOA3 nuclear receptor coactivator 3
NPC1 Niemann-Pick disease, type C1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4DIP phosphodiesterase 4D interacting protein
PHGDH phosphoglycerate dehydrogenase
PHIP pleckstrin homology domain interacting protein
PKP2 plakophilin 2
PLCB4 phospholipase C, beta 4
RAB29 RAB29, member RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RB1CC1 RB1-inducible coiled-coil 1
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SERTAD2 SERTA domain containing 2
SH3YL1 SH3 and SYLF domain containing 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SORBS2 sorbin and SH3 domain containing 2
SRGN serglycin
SSFA2 sperm specific antigen 2
SYBU syntabulin (syntaxin-interacting)
TAOK3 TAO kinase 3
TBC1D15 TBC1 domain family, member 15
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIMP3 TIMP metallopeptidase inhibitor 3
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR13 WD repeat domain 13
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
YIPF3 Yip1 domain family, member 3
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AK4 adenylate kinase 4
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CHEK1 checkpoint kinase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKB creatine kinase, brain
CLEC2B C-type lectin domain family 2, member B
CNN3 calponin 3, acidic
CYCS cytochrome c, somatic
DCTPP1 dCTP pyrophosphatase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECI2 enoyl-CoA delta isomerase 2
EIF4E eukaryotic translation initiation factor 4E
EIF5A eukaryotic translation initiation factor 5A
ELOVL5 ELOVL fatty acid elongase 5
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FASTKD5 FAST kinase domains 5
FEN1 flap structure-specific endonuclease 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GLO1 glyoxalase I
HCAR3 hydroxycarboxylic acid receptor 3
HDAC2 histone deacetylase 2
HELLS helicase, lymphoid-specific
HN1 hematological and neurological expressed 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIAA0101 KIAA0101
LAPTM4B lysosomal protein transmembrane 4 beta
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MEX3D mex-3 RNA binding family member D
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTCL1 microtubule crosslinking factor 1
MTERF3 mitochondrial transcription termination factor 3
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYBPC1 myosin binding protein C, slow type
NOL11 nucleolar protein 11
NREP neuronal regeneration related protein
OAT ornithine aminotransferase
ORC6 origin recognition complex, subunit 6
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PFN2 profilin 2
PLBD1 phospholipase B domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRDX1 peroxiredoxin 1
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PUS7 pseudouridylate synthase 7 (putative)
RFC2 replication factor C (activator 1) 2, 40kDa
RHOB ras homolog family member B
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
SACS sacsin molecular chaperone
SFN stratifin
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC35F2 solute carrier family 35, member F2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNX7 sorting nexin 7
SORD sorbitol dehydrogenase
SPON1 spondin 1, extracellular matrix protein
SRM spermidine synthase
SRSF10 serine/arginine-rich splicing factor 10
SRSF2 serine/arginine-rich splicing factor 2
STMN1 stathmin 1
TGM2 transglutaminase 2
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TMEM14A transmembrane protein 14A
TMEM97 transmembrane protein 97
TMX1 thioredoxin-related transmembrane protein 1
TRIP13 thyroid hormone receptor interactor 13
TUBB2A tubulin, beta 2A class IIa
TXNDC9 thioredoxin domain containing 9
TYMS thymidylate synthetase
TYRP1 tyrosinase-related protein 1
UNG uracil-DNA glycosylase
VCAN versican
ZMYM2 zinc finger, MYM-type 2
ZNF586 zinc finger protein 586