BRD-K73155123_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

47 genes differentially expressed following the BRD-K73155123_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CXCL2 chemokine (C-X-C motif) ligand 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA6 GATA binding protein 6
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
MT1M metallothionein 1M
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SNAI2 snail family zinc finger 2
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
AURKA aurora kinase A
COL5A2 collagen, type V, alpha 2
DPYSL2 dihydropyrimidinase-like 2
EMP3 epithelial membrane protein 3
GSTP1 glutathione S-transferase pi 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KIF20A kinesin family member 20A
NME4 NME/NM23 nucleoside diphosphate kinase 4
NTS neurotensin
PLK1 polo-like kinase 1
RAD23B RAD23 homolog B (S. cerevisiae)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TCF4 transcription factor 4
UBE2S ubiquitin-conjugating enzyme E2S
VCAN versican