BRD-K74155249_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

101 genes differentially expressed following the BRD-K74155249_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM9 ADAM metallopeptidase domain 9
AK4 adenylate kinase 4
ANXA10 annexin A10
CADM1 cell adhesion molecule 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAV2 caveolin 2
CCL5 chemokine (C-C motif) ligand 5
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CES1 carboxylesterase 1
DENND1B DENN/MADD domain containing 1B
DIXDC1 DIX domain containing 1
DPYSL3 dihydropyrimidinase-like 3
DTX4 deltex 4, E3 ubiquitin ligase
EIF5A eukaryotic translation initiation factor 5A
EREG epiregulin
FAM129A family with sequence similarity 129, member A
FAM189A2 family with sequence similarity 189, member A2
FBXL12 F-box and leucine-rich repeat protein 12
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FTH1 ferritin, heavy polypeptide 1
FXYD6 FXYD domain containing ion transport regulator 6
FZD1 frizzled class receptor 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLUL glutamate-ammonia ligase
HBB hemoglobin, beta
HDAC9 histone deacetylase 9
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HOMER2 homer scaffolding protein 2
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IDO1 indoleamine 2,3-dioxygenase 1
IPO13 importin 13
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KRT4 keratin 4, type II
LCN2 lipocalin 2
LPAR6 lysophosphatidic acid receptor 6
MAPT microtubule-associated protein tau
MATN2 matrilin 2
MDFIC MyoD family inhibitor domain containing
MEIS2 Meis homeobox 2
MTMR11 myotubularin related protein 11
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SOX2 SRY (sex determining region Y)-box 2
STAR steroidogenic acute regulatory protein
STON1 stonin 1
TIMP2 TIMP metallopeptidase inhibitor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPM2 tropomyosin 2 (beta)
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
TRPS1 trichorhinophalangeal syndrome I
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
AQP3 aquaporin 3 (Gill blood group)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BTBD3 BTB (POZ) domain containing 3
CCNA2 cyclin A2
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CD99 CD99 molecule
CDC42 cell division cycle 42
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COCH cochlin
CXCL13 chemokine (C-X-C motif) ligand 13
ECI2 enoyl-CoA delta isomerase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
GPC3 glypican 3
GRWD1 glutamate-rich WD repeat containing 1
KIF20A kinesin family member 20A
LAPTM4B lysosomal protein transmembrane 4 beta
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAT2A methionine adenosyltransferase II, alpha
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NUP62 nucleoporin 62kDa
PCOLCE procollagen C-endopeptidase enhancer
PKN2 protein kinase N2
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAD23B RAD23 homolog B (S. cerevisiae)
RPS27L ribosomal protein S27-like
SEPP1 selenoprotein P, plasma, 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SPATS2L spermatogenesis associated, serine-rich 2-like
STC2 stanniocalcin 2
STOM stomatin
TACC3 transforming, acidic coiled-coil containing protein 3
TCF4 transcription factor 4
TGFBI transforming growth factor, beta-induced, 68kDa
TRAPPC3 trafficking protein particle complex 3
TSPAN3 tetraspanin 3
UBE2S ubiquitin-conjugating enzyme E2S
Funding