BRD-K74305673_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-K74305673_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADRB2 adrenoceptor beta 2, surface
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHIC2 cysteine-rich hydrophobic domain 2
COL11A1 collagen, type XI, alpha 1
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DOK5 docking protein 5
EFNA1 ephrin-A1
EIF5 eukaryotic translation initiation factor 5
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FBN2 fibrillin 2
FHL2 four and a half LIM domains 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GTPBP2 GTP binding protein 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IFRD1 interferon-related developmental regulator 1
IGL immunoglobulin lambda locus
KIAA0753 KIAA0753
LAMB3 laminin, beta 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NPIPB3 nuclear pore complex interacting protein family, member B3
PDGFA platelet-derived growth factor alpha polypeptide
PEG3 paternally expressed 3
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PYCR1 pyrroline-5-carboxylate reductase 1
SCD5 stearoyl-CoA desaturase 5
SCG5 secretogranin V
SEC24D SEC24 family member D
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
STC2 stanniocalcin 2
SULF1 sulfatase 1
TNNT1 troponin T type 1 (skeletal, slow)
TRIB3 tribbles pseudokinase 3
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AKR1C1 aldo-keto reductase family 1, member C1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DUSP4 dual specificity phosphatase 4
ENDOD1 endonuclease domain containing 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FZD7 frizzled class receptor 7
G6PD glucose-6-phosphate dehydrogenase
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
H2AFX H2A histone family, member X
HSPA8 heat shock 70kDa protein 8
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
KIF20A kinesin family member 20A
LMNB1 lamin B1
MSH6 mutS homolog 6
MTDH metadherin
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
PROM1 prominin 1
QDPR quinoid dihydropteridine reductase
SRSF6 serine/arginine-rich splicing factor 6
TGM2 transglutaminase 2
TMEM2 transmembrane protein 2
TUBA4A tubulin, alpha 4a
TUBB4B tubulin, beta 4B class IVb
UBE2S ubiquitin-conjugating enzyme E2S