BRD-K74305673_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-K74305673_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BIRC2 baculoviral IAP repeat containing 2
BMP2 bone morphogenetic protein 2
BRD4 bromodomain containing 4
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CHIC2 cysteine-rich hydrophobic domain 2
COL15A1 collagen, type XV, alpha 1
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR3 early growth response 3
EREG epiregulin
EVI2A ecotropic viral integration site 2A
EZR ezrin
F11R F11 receptor
FNDC3B fibronectin type III domain containing 3B
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GEM GTP binding protein overexpressed in skeletal muscle
GPNMB glycoprotein (transmembrane) nmb
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
INHBA inhibin, beta A
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM6B lysine (K)-specific demethylase 6B
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MT2A metallothionein 2A
MYC v-myc avian myelocytomatosis viral oncogene homolog
PALLD palladin, cytoskeletal associated protein
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PER1 period circadian clock 1
PLAT plasminogen activator, tissue
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLVAP plasmalemma vesicle associated protein
RFC2 replication factor C (activator 1) 2, 40kDa
S100A8 S100 calcium binding protein A8
SEC14L1 SEC14-like 1 (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SON SON DNA binding protein
TGFA transforming growth factor, alpha
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D2 TSC22 domain family, member 2
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AKR1C2 aldo-keto reductase family 1, member C2
ATP9A ATPase, class II, type 9A
C6ORF62 chromosome 6 open reading frame 62
CKB creatine kinase, brain
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
DHRS2 dehydrogenase/reductase (SDR family) member 2
DPP4 dipeptidyl-peptidase 4
DPYSL2 dihydropyrimidinase-like 2
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
HMGN3 high mobility group nucleosomal binding domain 3
KDM5D lysine (K)-specific demethylase 5D
LGALS3 lectin, galactoside-binding, soluble, 3
METTL3 methyltransferase like 3
MSH6 mutS homolog 6
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PLAC8 placenta-specific 8
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOX11 SRY (sex determining region Y)-box 11
THAP11 THAP domain containing 11
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
WASF3 WAS protein family, member 3
Funding